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| 1 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 2 | Evaluation of seismic performance of multistory building structures based on the equivalent responses 显示文摘 | LEE D G CHOI W H CHEONG M C | 2006 | Engineering Structures2006，28，6： | 1 |
| 3 | A review of the optical properties of biological tissues显示文摘 | Cheong W F Prahl S A Welch A J | 1990 | IEEE J Quantum Electron1990，26，： | 1 |
| 4 | Deposition of aerosol particles in ductwork显示文摘 | CHEONG K W | 1997 | Applied Energy1997，57，4： | 1 |
| 5 | The effects of stabilizers on the bath stability of electroless Ni deposition and the deposit 显示文摘 | CHEONG W J LUAN B L SHOESMITH D W | 2004 | Appl Surf Sci2004，229，14： | 1 |
| 6 | Oviductal microsomal epoxide hydrolase(EPHX1) reduces reactive oxygen species (ROS)level and enhances preimplantation mouse embryo development 显示文摘 | CHEONG A W Y LEE Y L LIU W M | 2009 | Biol Reprod2009，81，： | 1 |
| 7 | Coffee fermentation and flavor-An intricate and delicate relationship显示文摘 | Lee L W Cheong M W Curran P | 2015 | Food Chemistry2015，185，1： | 1 |
| 8 | Multiferroics: A magnetic twist for ferroelectricit显示文摘 | Cheong S W Mostovoy M | 2007 | Nature Mater2007，6，： | 1 |
| 9 | Molecular and functional characterization of a cyclophilin with antifungal activity from Chinese cabbage 显示文摘 | LEE J R PARK S C KIM J Y LEE S S PARK Y CHEONG G W HAHM K S LEE S Y | 2007 | Biochem Biophys Res Commun2007，353，3： | 1 |
| 10 | Production of nuclear transfer derived swine that express the enhanced green fluorescent protein显示文摘 | PARK K W CHEONG H T LAI L | 2001 | Ani Biotech2001，12，2： | 1 |
| 11 | Effect of calcium powder addition on the quality characteristics of Kimchi 显示文摘 | Park W P Park K D Cheong Y J | 2002 | Journal of Korean Society of Food Science and Nutrition2002，31，： | 1 |
| 12 | 显示文摘 | Hwang H W Cheong S W Radaelli P G | 1995 | Phys Rev Lett1995，75，： | 1 |
| 13 | Molecular dynamics simulation of nano-indentation of carbon coated monocrystalline silicon 显示文摘 | Cheong W C D Zhang L C | 2006 | Fracture of Materials : Moving Forwards2006，312，： | 1 |
| 14 | A Molec- ular Dynamics Study of Scale Effects on the Fric- tion of Single- asperity Contacts 显示文摘 | Zhang L C Johnson K L Cheong W C D | 2001 | Tribology Letters2001，10，12： | 1 |
| 15 | Characteriza- tion of two fungal - elicitor induced rice cDNAs encoding functional homologues of the rab - specific GDP - dissoci- ation inhibitor显示文摘 | Kim W Y Kim C Y Cheong N E | 1999 | Planta1999，210，1： | 1 |
| 16 | Chain extension studies of wa- ter-borne polyurethanes from methyl ethyl ketoxime/e-caprolactam- blocked aromatic isocyanates 显示文摘 | Subramani S Cheong I W Kim J H | 2004 | Progress in Organic Coatings2004，51，4： | 1 |
| 17 | Isolation and identification of indigenous quorum quenching bacteria,pseudomonas sp 1A1,for biofouling control in MBR显示文摘 | Cheong W S Lee C H Moon Y H | 2013 | Industrial Engineering Chemistry Research2013，52，10： | 1 |
| 18 | Congenital nephro- genic diabetes insipidus with a novel mutation in the aqua- porin 2 gene显示文摘 | Park Y J Baik H W Cheong H I | 2014 | Biomed Rep2014，02，04： | 1 |
| 19 | Physical characterization of particulate matter and ambient meteorological parameters at different indooroutdoor locations in Singapore 显示文摘 | Gupta A Cheong K W | 2007 | Building and Environment2007，42，： | 1 |
| 20 | Dynamic performance of a curved cable-stayed bridge 显示文摘 | Brownjohn J M W Lee J Cheong B | 1999 | Engineering Structures1999，21，： | 1 |
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