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| 1 | Non-erosive and uncomplicated erosive reflux diseases:Difference in physiopathological and symptom pattern显示文摘AIM:To investigate differences in the physiopathological findings(manometry and pH monitoring) and symptoms between cases of non-erosive reflux disease(NERD) and erosive reflux disease(ERD) found positive at 24 h pH monitoring. METHODS:For a total of 670 patients who underwent 24 h pH monitoring,esophageal manometry and upper endoscopy were retrospectively evaluated,assessing the reflux symptoms,manometric characteristics of the lower esophageal sphincter(LES) and esophageal body and the presence or absence of esophagitis and hiatal hernia. Typical and atypical symptoms were also evaluated. For inclusion in the study,patients had to have NERD or ERD and be found positive on pH monitoring(NERD+) . Patients with Gastroesophageal reflux disease(GERD) complicated by stenosis,ulcers or Barrett's esophagus were ruled out. RESULTS:214 patients were involved in the study,i.e. 107 cases of NERD+ and 107 of ERD. There were no significant gender-or age-related differences between the two groups. The ERD group had more cases of hiatal hernia(P = 0.02) and more acid reflux,both in terms of number of reflux episodes(P = 0.01) and as a percentage of the total time with a pH < 4(P = 0.00) ,when upright(P = 0.007) and supine(P = 0.00) . The NERD+ cases had more reflux episodes while upright(P = 0.02) and the ERD cases while supine(P = 0.01) . The LES pressure was higher in cases of NERD+(P = 0.03) while the amplitude and duration of their esophageal peristaltic waves tended to be better than in the ERD group(P >0.05) . The NERD+ patients presented more often with atypical symptoms(P = 0.01) . CONCLUSION:The NERD+ patients' fewer reflux episodes and the fact that they occurred mainly while in the upright position(unlike the cases of ERD) may be two factors that do not favor the onset of esophagitis. The frequently atypical symptoms seen in patients with NERD+ need to be accurately evaluated for therapeutic purposes because patients with GERD and atypical symptoms generally respond only partially to medical and surgical treatments. | Vittorio Bresadola Gian Luigi Adani Francesco Londero Cosimo Alex Leo Vittorio Cherchi Dario Lorenzin Anna Rossetto Gianmatteo Vit Umberto Baccarani Giovanni Terrosu Dino De Anna | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，3： | 2 |
| 2 | Mixed RP/SP models incorporating interaction effects 显示文摘 | CHERCHI E | 2002 | Transportation2002，29，4： | 1 |
| 3 | Gradual hearing loss with bi lateral labyrinthine hemorrhage in chronic myelogenous leukemia显示文摘 | Cherchi M Huo E Nelson N | 2006 | Neurology2006，67，1： | 1 |
| 4 | Temperature-dependent thyroid hormone Biosynthesis in Testudo horsfieldi Gray显示文摘 | Emilio Balletto Maria A Cherchi Federico Melodia | 1979 | General and Comparative Endocrinology1979，39，4： | 1 |
| 5 | Molecular characterisation of novel family of cysteine-rich proteins of Toxoplasma gondii and ultrastructural evidence of oocyst wall localisation显示文摘 | Possenti A Cherchi S Bertuccini L | 2010 | Int J Parasitol2010，40，14： | 1 |
| 6 | Possible regression of left ventricular hypertrophy during antihypertensive treatment with diuretics and/ or beta blockers显示文摘 | Cherchi A Sau F Seguro C | 1987 | J Clin Hypertens1987，3，2： | 1 |
| 7 | The value of serum CA125 and association CA125 CA199 in endometrial 显示文摘 | Cherchi OL Dossole S Ruin GA | 1999 | Eur J Gynaecol Oncol1999，20，4： | 1 |
| 8 | Cis and trans regulatory elements in NPHS2 promoter: Implications in proteinuria and progression of renal diseases 显示文摘 | Di Duca M Oleggini R Sanna- Cherchi S | 2006 | Kidney Int2006，70，7： | 1 |
| 9 | Solid-phase extraction and high-performance liquid chromatographic de- termination of organic acids in honey 显示文摘 | Cherchi A Spanedda L Tuberoso C | 1994 | Journal of Chro- matography A1994，669，： | 1 |
| 10 | Mixed RP/SP models incorporating interaction effects 显示文摘 | Cherchi E de D Ortt-zar J | 2002 | Transportation2002，29，4： | 1 |
| 11 | The value of serum CA 125 and association CA 125/CA 19-9 in endometrial carcinoma显示文摘 | Cherchi PL Dessole S Ruiu GA | 1999 | Eur J Gynaeeol Oncol1999，20，4： | 1 |
| 12 | Migraine and tumour necrosis factor gene polymorphism 显示文摘 | ASUNI C STOCHINO M E CHERCHI A | 2009 | J Neurol2009，256，2： | 1 |
| 13 | The value of serum CA125 and the association CA125/CA19-9 in endometrial carcinoma显示文摘 | Cherchi PL Dessole S Ruiu GA | 1999 | Eur J Gynaecol Oncol1999，20，4： | 1 |
| 14 | Mixed RP/SP models incorpora- ting interaction effects显示文摘 | CHERCHI E De dios ORTUZARJ | 2002 | Transportation2002，29，4： | 1 |
| 15 | A Digital Self-Calibration Circuit for Absolute Optical Rotary Encoder Microsystems 显示文摘 | VALENTINO LIBERALI FABIO CHERCHI LUCA DISINGRINI | 2003 | IEEE2003，52，1： | 1 |
| 16 | The value of serum CA 125 and association CA 125/CA 19-9 in endometrial carcinoma显示文摘 | Cherchi PL Dessole S Ruiu GA | 1999 | Eur J Gynaecol Oncol1999，20，4： | 1 |
| 17 | Intraperitoneal alpha-2 interferon for advanced orarian cancer in complete remission or minial residual disease显示文摘 | Dessole S Esposito F | 1996 | J Gynecol Obstet Biol Reprod (paris)1996，25，1： | 1 |
| 18 | Intracystic evalua- tion of tumor markers in benign and malignant ovarian pathology 显示文摘 | Cherchi PL Capobianeo G Ambrcsini G | 2002 | Eur J Gynaecol Oncol2002，23，2： | 1 |
| 19 | Oligodendrocyte precursor cell maturation: role of adenosine receptors显示文摘Oligodendrocyte-formed myelin sheaths allow fast synaptic transmission in the brain and their degeneration leads to demyelinating diseases such as multiple sclerosis. Remyelination requires the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes but, in chronic neurodegenerative disorders, remyelination fails due to adverse environment. Therefore, a strategy to prompt oligodendrocyte progenitor cell differentiation towards myelinating oligodendrocytes is required. The neuromodulator adenosine, and its receptors(A1, A(2A), A(2B) and A3 receptors: A1R, A(2A)R, A(2B)R and A3R), are crucial mediators in remyelination processes. It is known that A1Rs facilitate oligodendrocyte progenitor cell maturation and migration whereas the A3Rs initiates apoptosis in oligodendrocyte progenitor cells. Our group of research contributed to the field by demonstrating that A(2A)R and A(2B)R inhibit oligodendrocyte progenitor cell maturation by reducing voltage-dependent K^+ currents necessary for cell differentiation. The present review summarizes the possible role of adenosine receptor ligands as potential therapeutic targets in demyelinating pathologies such as multiple sclerosis. | Federica Cherchi Anna Maria Pugliese Elisabetta Coppi | 2021 | Neural Regeneration Research2021，16，9： | 1 |
| 20 | Familial forms of nephrotic syndrome 显示文摘 | Caridi G Trivelli A Sanna - Cherchi S | 2010 | Pediatr Nephrol2010，25，2： | 1 |
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