|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Regulation of the osmotin gene promoter 显示文摘 | Kononowicz K Nelson D E Singh N K | 1992 | Plant Cell1992，，4： | 2 |
| 3 | COVID-19 and neurologic manifestations:a synthesis from the child neurologist’s corner显示文摘Background Since December 2019,the SARS-CoV-2 virus has been a global health issue.The main clinical presentation of this virus is a flu-like disease;however,patients with diverse neurologic manifestations have also been reported.In this review,we attempt to summarize,discuss and update the knowledge of the neurologic manifestations in the pediatric population affected by SARS-CoV-2 infection and the pandemic’s effects in children with neurologic diseases.Data sources This review analyzes studies found on the PubMed database using the following keywords:Neurologic manifestations COVID-19,Neurological COVID-19,coronavirus,SARS-CoV-2,pediatric COVID-19,COVID-19 in children,MIS-C,Pediatric Inflammatory Multisystem Syndrome,Guillain BarréSyndrome,Stroke,ADEM,and Anti-NMDA encephalitis.All studies cited were published between 2004 and 2022,and represent the most relevant articles in the field.The World Health Organization COVID-19 online dashboard was assessed to obtain updated epidemiological data.Results The most common neurologic symptoms in the pediatric population are headache,seizures,encephalopathy,and muscle weakness.These can be present during COVID-19 or weeks after recovering from it.Children who presented with multi-system inflammatory syndrome had a higher incidence of neurologic manifestations,which conferred a greater risk of morbidity and mortality.Several neuro-pathophysiological mechanisms have been proposed,including direct virus invasion,hyper-inflammatory reactions,multi-systemic failure,prothrombotic states,and immune-mediated processes.On the other hand,the COVID-19 pandemic has affected patients with neurologic diseases,making it challenging to access controls,treatment,and therapies.Conclusions Various neurologic manifestations have been associated with children’s SARS-CoV-2 infection.It is important to identify and give them proper and opportune treatment because they can be potentially grave and life-threatening;some can lead to long-lasting sequelae.Different neuro-pathophysiological mechanisms have been proposed,however,a causal relationship between SARS-CoV-2 infection and neurologic manifestations remains to be proven.Patients with neurologic diseases are especially affected by COVID-19,not only by the disease itself but also by its complications and pandemic management measures. | Carolina Valderas Gastón Méndez Alejandra Echeverría Nelson Suarez Katherin Julio Francisca Sandoval | 2022 | World Journal of Pediatrics2022，18，6： | 2 |
| 4 | Simultaneous detection of multiple nucleic acid targets in a geneous format显示文摘 | NELSON N J | 1994 | Biol Chem1994，153，： | 1 |
| 5 | Entrepreneurship Research in Emergence:Past Trends and Future Directions显示文摘 | BUSENITZ L W WEST G F SHEPHERD D NELSON T CHANDLER G N ZACHARAKIS A | 2003 | Journal of Management2003，29，3： | 1 |
| 6 | VH1,a provascular cell-specific receptor kinase that influences leaf cell patterns in Arabidopsis显示文摘 | Clay N K Nelson T | 2002 | Plant Cell2002，14，： | 1 |
| 7 | A photometric adaptation of the Somogy method for the determimation of glucose显示文摘 | Nelson N | 1944 | J Biol Chem1944，153，： | 1 |
| 8 | Finite element analysis of hyper-elastic components显示文摘 | Nieholson D W Nelson N | 1998 | Appl Meeh Rev1998，51，： | 1 |
| 9 | Salivarycortisol and mood and pain profiles duringskin-to-skin care for an unselected group of mothersand infants in neonatal intensive care 显示文摘 | Morelius E Theodorsson E Nelson N | 2005 | Pediatrics2005，116，： | 1 |
| 10 | Tree allometry and improved estimation of carbon stocks and balance in tropical forests显示文摘 | Chave J Andalo C Brown S Cairns M A Chambers J Q Eamus D Folster H Fromard F Higuchi N Kira T Lescure J P Nelson B W Ogawa H Puig H Riera B Yamakura T | | 0，，： | 1 |
| 11 | Evaluation of boron removal from water by hydrotalcite-like compounds 显示文摘 | O P Ferreira S G de Moraes0 Nelson Dura'n | 2006 | Chemosphere2006，62，1： | 1 |
| 12 | Effects of Fungal Laccase Immobilization Procedures for the Development of a Biosensor for Phenol Compounds显示文摘 | Renato S Freire Nelson Dura′n Lauro T | 2001 | Talanta2001，，54： | 1 |
| 13 | Gradual hearing loss with bi lateral labyrinthine hemorrhage in chronic myelogenous leukemia显示文摘 | Cherchi M Huo E Nelson N | 2006 | Neurology2006，67，1： | 1 |
| 14 | 2014 Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection 显示文摘 | AFDHAL N REDDY K NELSON D | 2014 | N Engl J Med2014，370，16： | 1 |
| 15 | Predictors of Shoulder and Back Injuries in Nursing Home Workers:A Prospective Study显示文摘 | Myers D Silverstein B Nelson N A | 2002 | Am J Ind Med2002，41，6： | 1 |
| 16 | Regulation of the osmotin gene promoter 显示文摘 | KONONOWICZ K NELSON D E Singh N K | 1992 | Plant Cell1992，，4： | 1 |
| 17 | Seasonal dynamics of colored dissolved material in the Sargasso Sea显示文摘 | NELSON N B SIEGEL D A MICHAELS A F | 1998 | Deep-Sea Re- search1998，45，： | 1 |
| 18 | Applications of Laccases and Tyrosinases (phenoloxidases) Immobilized on Different Supports:A Review显示文摘 | Nelson Durán Maria A Rosa Alessandro D'Annibale | 2002 | Enzyme and Microbial Technology2002，，31： | 1 |
| 19 | Green entrepreneurship and green value added 显示文摘 | Nelson O N Sumesh R N | 2009 | International Journal of Entre- preneurship2009，13，1： | 1 |
| 20 | XPS determination of the forms of nitrogen in coal pyrolysis chars 显示文摘 | GONG B BUCKLEY A N LAMB R N NELSON P F | 1999 | Sur Int Anal1999，28，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员