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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Influence of refractive error and axial length on retinal vessel geometric characteristics 显示文摘 | Lim LS Cheung CY Lin X | 2011 | Invest Ophthalmol Vis Sci2011，52，2： | 1 |
| 3 | Preparation and characterization of Biodegradable Poly-(L-lactide) / chitosan lends显示文摘 | Chen C ong LS Cheung MK | 2005 | European Polymer Journal2005，41，95： | 1 |
| 4 | The effect of exogenous estradiol treatment on the mRNA expression of vascular endothelial growth factor and its receptors in cultured human oviduct mucosal cells 显示文摘 | Lam PM Po LS Cheung LP | 2005 | J Assist Reprod Genet2005，22，6： | 1 |
| 5 | Knowledge of stroke in Hong Kong Chinese显示文摘 | Cheung RT Li LS Mak W | 1999 | Cerebrovasc Dis1999，9，2： | 1 |
| 6 | Feedback control of the EGFR signaling gradient: superposition of domain- splitting events in Drosophila oogenesis 显示文摘 | Zartman JJ Kanodia JS Cheung LS | 2009 | Development2009，136，17： | 1 |
| 7 | Clinical management for pa- tients admitted to a critical care unit with severe sepsis or septic shock显示文摘 | Cheung WK Chau LS Mak II | 2015 | Intensive Crit Care Nurs2015，31，6： | 1 |
| 8 | The effect of exogenous estradiol treatment on the mRNA expression of vascular endothelial growth factor and its receptors in cultured human oviduct mucosal cells显示文摘 | Lam PM Po LS Cheung LP | 2005 | J Assist Reprod Genet2005，22，6： | 1 |
| 9 | The effect of exogenous estradiol treatment on the mRNA expression of vascular endothelial growth factor and its receptors in cultured human oviduct mucosal cells显示文摘 | Lain PM Po LS Cheung LP | 2005 | J Assist Reprod Genet2005，22，6： | 1 |
| 10 | Adsorption of acid dyes by bamboo derived activated carbon显示文摘 | Chan LS Cheung WH Mc Kay G | 2008 | Desalination2008，218，13： | 1 |
| 11 | Upfront consolidation treatment with 131I-mIBG followed by myeloablative chemotherapy and hematopoietic stem cell transplantation in high-risk neuroblastoma显示文摘Importance:131I-metaiodobenzylguanidine(131I-mIBG)has a significant targeted antitumor effect for neuroblastoma.However,currently there is a paucity of data for the use of 131I-mIBG as a'front-line'therapeutic agent in those patients with newly diagnosed high-risk neuroblastoma as part of the conditioning regimen for myeloablative chemotherapy(MAC).Objective:To evaluate the feasibility of upfront consolidation treatment with 131I-mIBG plus MAC and hematopoietic stem cell transplantation(HSCT)in high-risk neuroblastoma patients.Methods:A retrospective,single-center study was conducted from 2003-2019 on newly diagnosed high-risk neuroblastoma patients without progressive disease(PD)after the completion of induction therapy.They received 131I-mIBG infusion and MAC followed by HSCT.Results:A total of 24 high-risk neuroblastoma patients were enrolled with a median age of 3.0 years at diagnosis.After receiving this sequential consolidation treatment,3 of 13 patients who were in partial response(PR)before 131I-mIBG treatment achieved either complete response(CR)(n=1)or very good partial response(VGPR)(n=2)after HSCT.With a median follow-up duration of 13.0 months after 131I-mIBG therapy,the 5-year event-free survival and overall survival rates estimated were 29%and 38%for the entire cohort,and 53%and 67%for the patients who were in CR/VGPR at the time of 131I-mIBG treatment.Interpretation:Upfront consolidation treatment with 131I-mIBG plus MAC and HSCT is feasible and tolerable in high-risk neuroblastoma patients,however the survival benefit of this 131I-mIBG regimen is only observed in the patients who were in CR/VGPR at the time of 131I-mIBG treatment. | Jianhua Feng Frankie WT Cheng Alex WK Leung Vincent Lee Eva WM Yeung Hoi Ching Lam Jeanny Cheung Grace KS Lam Terry TW Chow Carol LS Yan Chi Kong Li | 2020 | Pediatric Investigation2020，4，3： | 1 |
| 12 | Structural changes in the retinal microvasculature and renal function 显示文摘 | Lira LS Cheung CY Sabanayagam C | 2013 | Invest Ophthalmol Vis Sci2013，54，4： | 1 |
| 13 | The effect of exogenous estradiol treatment on the mRNA expression of vascular endothelial growth factor and its receptors in cultured human oviduct mucosal sells 显示文摘 | Lam PM Po LS Cheung LP | 2005 | J Assist Reprod Genet2005，22，6： | 1 |
| 14 | The effect of exogenous estradiol treatment on the mRNA expression of vascular endothelial growth factor and receptors and its receptors in cultured human oviduct mucosal cells显示文摘 | Lain PM Po LS Cheung LP | 2005 | J Assist Reprod Genet2005，22，6： | 1 |
| 15 | The effect of exogenous estradiol treatment on the mRNA expression of vascular endothelial growth factor and its receptors in cultured human oviduct mucosal cells显示文摘 | Lam PM Po LS Cheung LP | 2005 | J Assist Reprod Genet2005，22，6： | 1 |
| 16 | Oncogenic Kras initiates leukemia inhematopoietic stem cells 显示文摘 | Sabnis AJ Cheung LS Dail M | 2009 | PLoS Biol2009，7，10： | 1 |
| 17 | Evaluation of focal choroidal excavation in the macular using swept-source optical coherence tomography显示文摘 | Lim FP Loh BK Cheung CM Lim LS Chan CM Wong DW | 2014 | Eye2014，28，9： | 1 |
| 18 | Biomechanics of leukocyte rolling显示文摘 | Sundd P Pospieszalska MK Cheung LS | | 0，，： | 1 |
| 19 | Influence of refractive error and axial length on retinal vessel geometric characteristics显示文摘 | Lim LS Cheung CY Lin X | 2011 | Invest Ophthalmol Vis Sci2011，522，： | 1 |
| 20 | Percutaneous left ventricular 'vent' insertion for left heart decompression during extracorporeal membrane oxygenation显示文摘 | Cheung MM Goldman AP Shekerdemian LS | 2003 | Pediatr Crit Care Med2003，4，4： | 1 |
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