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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | 4例虹膜蔓状血管瘤光学相干体层成像术血管造影特征显示文摘血管畸形中失调的TGF-β/BMP信号通路
血管树正确的结构要求调控管腔形成,血管生长和重塑的信号通路激活并达到平衡。当这一平衡被打破时,会出现血管发育畸形。该文旨在回顾转化生长因子(TGF)-β、骨形成蛋白(BMP)信号通路在血管形成和发展中的作用。胚胎期灭活这些信号通路,将导致血管组织变异。 | Chien JL Sioufi K Ferenczy S Say EAT 张凌 Cunha SI Magnusson PU Dejana E | 2017 | 中国口腔颌面外科杂志2017，15，6： | 6 |
| 3 | Relevant term suggestion in interactive Web search based on contextual information in query session logs显示文摘 | Huang C K Chien L F Oyang Y J | 2003 | JASIST2003，54，7： | 1 |
| 4 | A practical(t,n) multi secret sharing scheme显示文摘 | Chien H Y Jan J K Tseng Y M | 2000 | IEICE Transactions on Fundamentals2000，83，12： | 1 |
| 5 | Use of serum homocysteine to predict stroke,coronary heart disease and death in ethnic chinese--12--year pro --spective cohort study显示文摘 | Sun Y Chien K Hsu H | 2009 | Circ J2009，73，： | 1 |
| 6 | Advanced-MVA mobile technology for fast-switching LCD displays 显示文摘 | Hsu S F Chien WY Wu K H etal | 2008 | SID Symposium Digest 392008，，： | 1 |
| 7 | Control of mineral scale deposition in cooling systems using secondary-treated municipal wastewater显示文摘 | LI H HSIEH M K CHIEN S H | 2011 | Water Research2011，45，2： | 1 |
| 8 | Relevant term suggestion in interactive web search based on contextual information in query session logs 显示文摘 | Huang C K Chien L F Oyang Y J | 2003 | Journal of the American Society for Information Science and Technology2003，54，7： | 1 |
| 9 | A simplified transient three - dimensional model for estimating the thermal performance of the vapor chambers显示文摘 | Chen Y S Chien K H Wang C C | 2006 | Applied Thermal Engineering2006，26，： | 1 |
| 10 | Time course of acylcarni- tine elevation in neonatal in -trahepatic cholestasis caused by cit- tin deficiency显示文摘 | Lee NC Chien YH Kobayashi K | 2006 | J Inherit Metab Dis2006，29，4： | 1 |
| 11 | SLC25A13 gene mutations in Taiwanese patients with non-viral hepatocellular carcinoma 显示文摘 | Chang K W Chen H L Chien Y H | 2011 | Mol Genet Metab2011，103，3： | 1 |
| 12 | Correlation between processing parameters and microstructure of electrospun poly(D, L-lactic acid) nanofibers显示文摘 | Wang C Chien H S Yan K W | 2009 | Polymer2009，50，25： | 1 |
| 13 | Immunomodulatory effect of exo- polysaccharides from submerged cultured Cordyceps sinensis: enhancement of cytokine synthesis, CD11 b expression, and phagocy- tosis 显示文摘 | MEI C K CHIEN Y C TSO L C | 2007 | Appl Microbiol Biotechnol2007，，75： | 1 |
| 14 | A Practical (t, n) Multi-secret Sharing Scheme 显示文摘 | Chien H Y JAN J K Tseng Y M | 2000 | IEICE Trans on Fundamentals2000，83，12： | 1 |
| 15 | Efficient siRNA delivery using water soluble lipopolymer for anti- angiogenic gene therapy 显示文摘 | WON J K CHIEN W C MINHYUNG L | 2007 | J Control Release2007，118，3： | 1 |
| 16 | Control of biological growth in recirculating cooling systems using treated secondary effluent as makeup water with monochloramine显示文摘 | CHIEN S H CHOWDHURY I HSIEH M K | 2012 | Water Research2012，46，19： | 1 |
| 17 | OTA-based monostable multivibrators with current tuning properties显示文摘 | Chien H C Lo Y K | 2011 | Microelectronics Journal2011，42，： | 1 |
| 18 | Novel polysulfides identified in the volatile components from onions and scallions 显示文摘 | May Chien K Mingjien C Chi Tang H | 1990 | J Agri Food Chem1990，38，： | 1 |
| 19 | Efficient and convenient nonaqueous workup procedure for the preparation of arylboronic esters 显示文摘 | Wong K Chien YY Liao YL | 2002 | J Org Chem2002，67，3： | 1 |
| 20 | Escalating water de- mand for energy production and the potential for use of treated municipal wastewater显示文摘 | Li H Chien S H Hsieh M K | 2011 | Environ Sci Technol2011，45，10： | 1 |
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