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| 1 | Upper gastrointestinal tract capsule endoscopy using a nurse-led protocol: First reported experience显示文摘AIM To test the feasibility and performance of a novel upper gastrointestinal(GI) capsule endoscope using a nurse-led protocol. METHODS We conducted a prospective cohort analysis of patients who declined gastroscopy(oesophagogastroduodenoscopy, OGD) but who consented to upper GI capsule endoscopy. Patients swallowed the upper GI capsule following ingestion of 1 liter of water(containing simethicone). A series of positional changes were used to exploit the effects of water flow and move the upper GI capsule from one gravity-dependent area to another using a nurse-led protocol. Capsule transit time, video reading time, mucosal visualisation, pathology detection and patient tolerance was evaluated.RESULTS Fifty patients were included in the study. The mean capsule transit times in the oesophagus and stomach were 28 s and 68 min respectively. Visualisation of the following major anatomical landmarks was achieved(graded 1-5: Poor to excellent): Oesophagus, 4.8(± 0.5); gastro-oesophageal junction(GOJ), 4.8(± 0.8); cardia, 4.8(± 0.8); fundus, 3.8(± 1.2); body, 4.5(± 1); antrum, 4.5(± 1); pylorus, 4.7(± 0.8); duodenal bulb, 4.7(± 0.7); second part of the duodenum(D2), 4.7(± 1). The upper GI capsule reached D2 in 64% of patients. The mean video reading time was 48 min with standard playback mode and 20 min using Quickview(P = 0.0001). No pathology was missed using Quickview. Procedural tolerance was excellent. No complications were seen with the upper GI capsule. CONCLUSION The upper GI capsule achieved excellent views of the upper GI tract. Future studies should compare the diagnostic accuracy between upper GI capsule and OGD. | Hey-Long Ching Ailish Healy Victoria Thurston Melissa F Hale Reena Sidhu Mark E McAlindon | 2018 | World Journal of Gastroenterology2018，24，26： | 9 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 4 | Effect of varying computed tomography acquisition and reconstruction parameters on semi-automated clot volume quantification显示文摘AIM To examine effects of computed tomography(CT)image acquisition/reconstruction parameters on clot volume quantification in vitro for research method validation purposes.METHODS This study was performed in conformance with HIPAA and IRB Regulations(March 2015-November 2016).A ten blood clot phantom was designed and scanned on a dual-energy CT scanner(SOMATOM Force,Siemens Healthcare Gm BH,Erlangen,Germany)with varying pitch,iterative reconstruction,energy level and slicethickness.A range of clot and tube sizes were used in an attempt to replicate in vivo emboli found within central and segmental branches of the pulmonary arteries in patients with pulmonary emboli.Clot volume was the measured parameter and was analyzed by a single image analyst using a semi-automated region growing algorithm implemented in the FDA-approved Siemens syngo.via image analysis platform.Mixed model analysis was performed on the data.RESULTS On the acquisition side,the continuous factor of energy showed no statistically significant effect on absolute clot volume quantification(P=0.9898).On the other hand,when considering the fixed factor of pitch,there were statistically significant differences in clot volume quantification(P<0.0001).On the reconstruction side,with the continuous factor of reconstruction slice thickness no statistically significant effect on absolute clot volume quantification was demonstrated(P=0.4500).Also on the reconstruction side,with the fixed factor of using iterative reconstructions there was also no statistically significant effect on absolute clot volume quantification(P=0.3011).In addition,there was excellent R^2 correlation between the scale-measured mass of the clots both with respect to the CT measured volumes and with respect to volumes measure by the water displacement method.CONCLUSION Aside from varying pitch,changing CT acquisition parameters and using iterative reconstructions had no significant impact on clot volume quantification with a semi-automated region growing algorithm. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，3： | 3 |
| 5 | Higher-order multivariate Markov chains and their applications显示文摘 | Ching W K Ng M K Fung E S | 2008 | Linear Algebra and its Applications2008，428，2： | 1 |
| 6 | Binaural redundancy an d int er-aural time difference cues f or patients wearing a cochlear implant and a hearing aid in opposite ears显示文摘 | Ching TYC van Wanrooy E Hi ll M | 2005 | Int J Audiol2005，44，： | 1 |
| 7 | Synthesis of continuous MOF-5 membranes on porous a- alumina substrates 显示文摘 | Liu Y Ng Z Khan E Jeong H K Ching C Lai Z | 2009 | Microporous Mesoporous Materials2009，118，123： | 1 |
| 8 | Imerphase precipltadon of nanometer-sized carbides in a titanium molybdenum bearing low carbon steel显示文摘 | Hung W Y Po Y C Ching Y H e* al | 2011 | Acta Materialia2011，59，： | 1 |
| 9 | Higher-order multivariate Markov chains and their applications显示文摘 | Ching W K Ng M K Fung E S | 2008 | Linear Algebra and its Applica- tions2008，428，2： | 1 |
| 10 | DNA adduct formation and DNA strand breaks in green-lipped mussels (Perna viridis) exposed to benzo pyrene : Dose-and time-dependent relation- ships显示文摘 | CHING E W SIU W H LAM P K | 2001 | Marine Pollution Bulletin2001，42，： | 1 |
| 11 | A multivariate Mark- ov chain model for categorical data sequences and its applications in demand predictions显示文摘 | Ching W K Fung E S Ng M K | 2002 | IMA Journal of Management Mathematics2002，13，3： | 1 |
| 12 | An optimization algorithm for clustering using weighted dissimilarity measures显示文摘 | Chan E Y Ching W K Ng M K | 2004 | Pattern Recognition2004，37，： | 1 |
| 13 | Higher-order multi- variate Markov chains and their applications显示文摘 | Ching W K Ng M K Fung E S | 2008 | Linear Algebra and its Applications2008，428，2： | 1 |
| 14 | Correlation of Crude Oil Steam Distillation Yields with Basic Crude Oil Properties显示文摘 | Ching H W Robert B E | 1983 | SPE J1983，23，6： | 1 |
| 15 | Influence of annealing on the microstructural, tensile and fracture properties of Polypropylene films显示文摘 | FERRER-BALAS D MASPOCH M L MARTINEZ A B CHING E MAI Y W | 2001 | Polymer2001，42，： | 1 |
| 16 | Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway显示文摘 | Ching C B Hansel D E | 2010 | Lab Invest2010，90，10： | 1 |
| 17 | Genes associated with the end of dormancy in grapes 显示文摘 | PACEY-MILLER T SCOTY K ABLETY E TINGEY S CHING A HENRY R | 2003 | Fuctional Integrative Genomics2003，3，4： | 1 |
| 18 | An optimization algo- rithm for clustering using weighted dissimilarity measures显示文摘 | Chan E Y Ching W K Ng M K | 2004 | Pattern Recognition2004，37，5： | 1 |
| 19 | Construction and characterization of a high-flow,high-resolution ion mobility spectrometer for detection of explosives after personnel portal sampling显示文摘 | Steiner W E Tornatore J E | 2002 | Talanta2002，57，： | 1 |
| 20 | Correction of the measurement of fiber length of short fiber reinforced thermo- plastics显示文摘 | Fu S Y Mai Y W Ching E C | 2002 | Composites Part A:Applied Science and Manufacturing2002，33，11： | 1 |
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