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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Synthesis of continuous MOF-5 membranes on porous a- alumina substrates 显示文摘 | Liu Y Ng Z Khan E Jeong H K Ching C Lai Z | 2009 | Microporous Mesoporous Materials2009，118，123： | 1 |
| 3 | Imerphase precipltadon of nanometer-sized carbides in a titanium molybdenum bearing low carbon steel显示文摘 | Hung W Y Po Y C Ching Y H e* al | 2011 | Acta Materialia2011，59，： | 1 |
| 4 | Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway显示文摘 | Ching C B Hansel D E | 2010 | Lab Invest2010，90，10： | 1 |
| 5 | Correction of the measurement of fiber length of short fiber reinforced thermo- plastics显示文摘 | Fu S Y Mai Y W Ching E C | 2002 | Composites Part A:Applied Science and Manufacturing2002，33，11： | 1 |
| 6 | Asymmetric distribution of convection associated with tropical cyclones making landfall along the South China coast显示文摘 | Chan J C L Liu K S Ching S E | 2004 | Mo Wea Rev2004，132，： | 1 |
| 7 | Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitisinduced injury显示文摘 | Xiao J Liong E C Ching Y P | 2013 | Nutr Diabetes2013，3，： | 1 |
| 8 | Statistical preserved structures and anomalous scaling in turbulent active scalar advection 显示文摘 | CHING E S C COHEN Y GILBERT T | 2002 | Europhys Lett2002，60，： | 1 |
| 9 | Active and passive fields in turbulent transport: the role of statistically preserved structures 显示文摘 | CHING E S C COHEN Y GILBERT T | 2003 | Phys Rev E2003，67，01： | 1 |
| 10 | GPS crustal deformation,strain rate,and seismic activity after the 1999 Chi-Chi earthquake in Taiwan显示文摘 | LIN K C HU J C CHING K E | 2010 | J Geophys Res2010，115，07： | 1 |
| 11 | Refined similarity for a randomly advected passive scalar显示文摘 | CHING E S C | 1997 | Phys Rev Lett1997，79，： | 1 |
| 12 | Characterization of hazardous,air pollution emitted from motor vehicles 显示文摘 | hiang P C Ching Y C Ching E E | 1996 | ToxicologicalEnvironmental Chemistry1996，56，14： | 1 |
| 13 | Characteristics of organic precursors and their relationship with disinfection by-products显示文摘 | Chang E E Ching P C Ko Y W | 2001 | Chemosphere2001，44，： | 1 |
| 14 | Asymmetric Distribution of convection associated with tropical cyclones making landfall along the south China coast显示文摘 | CHAN J C L LIU K S CHING S E | 2004 | Mon Wea Rev2004，132，10： | 1 |
| 15 | Lycium barbarum polysaccharides protect mice fiver from carbon tetrachloride-in- duced oxidative stress and necroinflammation显示文摘 | XIAO J LIONG E C CHING Y P | 2012 | Journal of Ethnopharmacology2012，，139： | 1 |
| 16 | Preparative resolution of praziquantel enantiomers by simulated counter-current chromatography显示文摘 | Ching C B Lim B G Lee E J D | 1993 | J Chromatogr A1993，634，： | 1 |
| 17 | Asymmetric distribution of convection associated with tropical cyclones making landfall along the South China coast显示文摘 | CHAN J C L LIU K S CHING E | 2004 | Monthly Weather Review2004，132，10： | 1 |
| 18 | Lamivudine is effective in suppressing hepatitis B virus DNA in Chinese hepatitis B surface antigen carriers: A placebo-controlled trial显示文摘 | C Lai C Ching AK Tung E Li J Young A Hill BC Wong J Dent P Wu | 1997 | Hepatology1997，，1： | 1 |
| 19 | On the liquid turbulence energy spectra in two-phase bubbly flow in a large diameter vertical pipe显示文摘 | Shawkat M E Ching C Y Shoukri M | 2007 | International Journal of Multiphase Flow2007，33，3： | 1 |
| 20 | Probability densities of turbulent temperature fluctuations显示文摘 | Ching E S C | 1993 | Physics Rewiew Letters1993，70，3： | 1 |
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