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| 1 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | Separation of thoracopagus conjoined twins:A case report显示文摘 | Chiu CT Hou SH Lai HS | 1994 | J Cardiovasc Surg1994，35，5： | 1 |
| 3 | Heterotopic triplet pregnancy : report of a case with bilateral tubal pregnancy and intrauterine pregnancy 显示文摘 | Pan HS Chuang J Chiu SF | 2002 | Hum Reprod2002，17，5： | 1 |
| 4 | Clinical evaluation of repeat percutaneous vertebroplasty for symptomatic cemented vertebrae显示文摘 | Chiu YC Yang SC Chen HS | 2012 | J Spinal Disord Tech2012，25，8： | 1 |
| 5 | Obstructive sleep apnea presenting with nocturnal angina, heart failure ,and near miss sudden death 显示文摘 | Chan HS Chiu HF Tse LK | 1991 | Chest1991，99，4： | 1 |
| 6 | Strategies for Sus- tainable Development Industrial Park in Ulsan, South Korea -from Spontaneous Evolution to Systematic Expansion of Industrial Symbiosis显示文摘 | Park HS Rene ER Choi SM Chiu AS | 2008 | Environmental Management2008，87，01： | 1 |
| 7 | Separation of thoracopagus conjoined twins,a case report显示文摘 | Chiu CT Hou SH Lai HS | 1994 | J Cardiovasc Surg1994，35，5： | 1 |
| 8 | A prepective study of the frequency and topographic distribution of colon neoplasia in asymptomatic average-risk Chinese adults as determined by coloscopic screening显示文摘 | Chiu HM Wang HS Lee YC | 2005 | Gastrointest Endosc2005，62，3： | 1 |
| 9 | Post -- traumatic fat embolism--its clinical and subclinical presentations显示文摘 | Chan KM Than KT Chiu HS | 1984 | The Journal of Trauma1984，24，1： | 1 |
| 10 | An extensive microRNAmediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma显示文摘 | Sumazin P Yang X Chiu HS | | 0，，02： | 1 |
| 11 | Molecular investigation of two clusters of hospital-acquired bacteraemia caused by multi-resistant Klebsiella pneumoniae using pulsed-field gel electrophoresis and infrequent restriction site PCR显示文摘 | Leu HS Chiu YP | 2000 | J Hosp Infect2000，46，2： | 1 |
| 12 | Increased risk of preterm delivery in areas with air pollution from a petroleum refinery plant in Taiwan显示文摘 | Lin MC Chiu HF Yu HS | | 0，，08： | 1 |
| 13 | Hypertonic saline reduces cumulative and daily intracranial pressure burdens after severe traumatic brain injury显示文摘 | Mangat HS Chiu YL Gerber LM | 2015 | J Neurosurg2015，122，1： | 1 |
| 14 | Obstructive sleep apnea presenting with nocturnal angina,heart failure,and near miss sudden death显示文摘 | Ghan HS Chiu HF Tse LK | 1991 | Chest1991，99，4： | 1 |
| 15 | Hyalinizing trabecular adenoma- Like lesion in multinodular goitre 显示文摘 | Chan JKC Tse CCH Chiu HS | 1990 | Histopathology1990，16，： | 1 |
| 16 | Heterotopic tripletpregnancy:report of a case with bilateral tubal pregnancyand an intrauterine pregnancy显示文摘 | Pan HS Chuang J Chiu SF | 2002 | Hum Reprod2002，17，： | 1 |
| 17 | Treatment of a tufted angioma with intense pulsed light显示文摘 | Chiu CS Yang LC Hong HS | 2007 | J Dermatolog Treat2007，18，2： | 1 |
| 18 | Heterotopic triple pregnancy:report of a case with bilateral tubal pregnancy and an intrauterine pregnancy显示文摘 | Pan HS Chuang J Chiu SF | | 0，，05： | 1 |
| 19 | Increased risk of preterm delivery in areas with air pollution from a petroleum refinery plant in Taiwan显示文摘 | Lin MC Chiu HF Yu HS | 2001 | J Toxicol Environ Health2001，64，8： | 1 |
| 20 | Medical Expenditure and Family Satisfaction Between Hospice and General Care in Terminal Cancer Patients in Taiwan 显示文摘 | Lin WY Chiu TY Hsu HS | 2009 | J Formos Med Assoc2009，108，10： | 1 |
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