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| 1 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 2 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 3 | Two heuristics for scheduling multiple projects with resource constraints显示文摘 | TSAI D M CHIU H N | 1996 | Construction Management and Economies1996，14，4： | 1 |
| 4 | Differentiation expression of telomerase activity in hematopoietic progenitor from human bone marrow 显示文摘 | CHIU CH-P DRAGOWSHA W KIM N M | 1996 | Stem Cells1996，14，2： | 1 |
| 5 | A sensitive and robust method for the determination of alkylphenol polyethoxylates and their carboxylic acids and their transformation in a trickling filter wastewater treatment plant显示文摘 | Koh Y K K Chiu T Y Boobis A R Cartmell E Pollard S J T Scrimshaw M D I_ester J N | 2008 | Chemosphere2008，73，4： | 1 |
| 6 | A fuzzy multi-criteria decision making approach for solving a bi-objective personnel assignment problem显示文摘 | Huang D K Chiu H N Yeh R H | 2009 | Computers & Industrial Engineering2009，56，1： | 1 |
| 7 | Cleft size at the time of palate repair in complete unilateral cleft lip and palate as an indicator of maxillary growth显示文摘 | Y-F Liao N K K Prasad Y-T Chiu | | 0，，： | 1 |
| 8 | Control of carbon and ammonium ratio for simultaneous nitrification and denitrification in a sequencing batch bioreactor显示文摘 | Chiu Y C Lee L L Chang C N | 2007 | International Biodeterioration & Biodegradation2007，59，： | 1 |
| 9 | Genetically engineered live attenuatedinfluenza A virus vaccie candidates显示文摘 | Parkin N Chiu P Coeling H K | 1997 | Virol1997，，71： | 1 |
| 10 | Control of carbon and ammonium ratio for simultaneous nitrification and denitrification in a sequencing batch bioreactor显示文摘 | Chiu Y C Lee L L Chang C N | | 0，，59： | 1 |
| 11 | Simultaneous liposomal deliv-ery of quercetin and vineristine for enhanced estrogen- receptor-negative breast cancer treatment 显示文摘 | WONG M Y CHIU G N | 2010 | Anti- Cancer Drugs2010，21，4： | 1 |
| 12 | Immunological study of hal domain of he- magglutinin of influenza hSnl virus 显示文摘 | Chiu F F Venkatesan N Wu C R Chou A H Chen H W Lian S P Liu SJ Huang C C Lian W C Chong P Leng C H | 2009 | Biochemical Biophys ResCommun2009，383，1： | 1 |
| 13 | Vascular endothelial growth factor synergistically enhances bone morphogenetic protein-4-dependent lymphohematopoietic cell generation from embryonic stem cells in vitro 显示文摘 | Nakayama N Lee J Chiu L | 2000 | Blood2000，95，7： | 1 |
| 14 | Lentivirally mediated GSK-3beta silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice 显示文摘 | Omata N Chiu C T Moya P R | 2011 | Int J Neuro- psychopharmacol2011，14，5： | 1 |
| 15 | Detection of restriction enzyme-digested target DNA by PCR amplification using a stem-loop primer: application to the detection of hypomethylated fetal DNA in maternal plasma 显示文摘 | Tong Y K Chiu R W Leung T Y Ding C Lau T K Leung T N | 2007 | Clin Chem2007，53，： | 1 |
| 16 | Two heuristics for scheduling multiple project s with resource constraints显示文摘 | TSAI D M CHIU H N | 1996 | Construction Management and Economics1996，14，4： | 1 |
| 17 | Applying fuzzy neural network to estimate software development effort显示文摘 | Huang S J Chiu N H | 2009 | Applied Intelligence2009，30，2： | 1 |
| 18 | Chronotropic incompetence in young patients with late postoperative atrial flutter: acase eontrolstudy显示文摘 | Anand N McCrindle BW Chiu CC et ai | 2006 | EurHeartJ2006，27，17： | 1 |
| 19 | Intelligent aircraft maintenance support system using genetic algorithms and casebased reasoning显示文摘 | Chiu C Chiu N H Hsu C I | 2004 | The International Journal of Advanced Manufacturing Technology2004，24，5： | 1 |
| 20 | Aerogel synthesis of yttria-stabilized zirconia by a non alkoxide sol-gel route显示文摘 | Chervin C N Clapsaddle B J Chiu H W | 2005 | Chemistry of Materials2005，17，33： | 1 |
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