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| 1 | Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia. | Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 2 | On the linear hydrodynamic forces and the maneuverability of an unmanned untethered submersible with streamlined body (2nd Report)显示文摘 | CHIU F C and GUO J and HUANG C C and WANG J P | 1997 | Journal of Society of Naval Architects of Japan1997，182，： | 2 |
| 3 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 4 | Preparation and characterization of urease immobilized onto porous chitosan beads for urea hydrolysis显示文摘 | Chiu S H | 1999 | Bioprocess Engeneering1999，21，： | 1 |
| 5 | Origin of Field-Dependent Optical Transmission of Magnetic Fluid Films显示文摘 | Chiu Y P Jeang B Y | 2001 | Applied Physics Letters2001，79，： | 1 |
| 6 | Autocrine motility factor receptor:a clinical review显示文摘 | Chiu CG St Pierre P Nabi IR | 2008 | Expert Rev Anticancer Ther2008，8，2： | 1 |
| 7 | A near-optimal sensor placement algorithm to achieve complete coverage/discrimination in sensor networks显示文摘 | F Y S Lin P L Chiu | 2005 | IEEE Communications Letters2005，9，1： | 1 |
| 8 | Polycystic ovaries are common in women with hyperandrogenic chronic anovulation but do not predict metabolic or reproductive phenotype 显示文摘 | Legro RS Chiu P Kunselman AR | 2005 | J Clin Endocrinol Metab2005，90，5： | 1 |
| 9 | A low distortion map between disk and square 显示文摘 | Shirley P Chiu K | 1997 | Journal of Graphics Tools1997，2，3： | 1 |
| 10 | Gender differs: assessing a model of online purchase intentions in e-tail service 显示文摘 | Chiu Y B Lin C P Tang L L | 2005 | Inernational Journal of Service Industry Management2005，16，41： | 1 |
| 11 | Anti-inflammatory flavonoids from A rtocarpus heterophyllus and Artocarpus communis显示文摘 | Wei B L Weng J R Chiu P H | 2005 | J Agr Food Chem2005，53，10： | 1 |
| 12 | Pseudolaric acids:isolation,bioactivity and synthetic studies显示文摘 | Chiu P Leung L T Ko B C | | 0，，07： | 1 |
| 13 | A 12-bit,45-MS/s,3-mW Redundant Successive-approximation-register Analog-to-digital Converter with Digital Calibration 显示文摘 | Liu W Huang P Chiu Y | 2011 | IEEE Journal of Solid-state Circuits2011，46，11： | 1 |
| 14 | Low efficacy of serum levels CAI9 -9 in prediction of malignant diseases in asymptomatic population in Taiwan 显示文摘 | Locker G Y Huang S P Chiu H M | 2006 | Hepatogastro-enterology2006，53，67： | 1 |
| 15 | Comparative analysis between psychological and endoscopic pro- files in patients with gastroesophageal reflux disease: a prospective study based on screening endoscopy显示文摘 | Lee Y C Wang H P Chiu H M | 2006 | J Gastroenterol Hepatol2006，21，5： | 1 |
| 16 | Genetically engineered live attenuatedinfluenza A virus vaccie candidates显示文摘 | Parkin N Chiu P Coeling H K | 1997 | Virol1997，，71： | 1 |
| 17 | Halogenated polycyclic aromatic hydrocarbons:A class of genotoxic environmental pollutants显示文摘 | Fu P P Von Tungeln L S Chiu L H | 1999 | Journal of Environmental Science and Health1999，17，2： | 1 |
| 18 | Immunological study of hal domain of he- magglutinin of influenza hSnl virus 显示文摘 | Chiu F F Venkatesan N Wu C R Chou A H Chen H W Lian S P Liu SJ Huang C C Lian W C Chong P Leng C H | 2009 | Biochemical Biophys ResCommun2009，383，1： | 1 |
| 19 | Microbial reduction of perchlorate with zero-valent iron显示文摘 | Son A Lee J Chiu P C | 2006 | Water Research2006，40，10： | 1 |
| 20 | Lentivirally mediated GSK-3beta silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice 显示文摘 | Omata N Chiu C T Moya P R | 2011 | Int J Neuro- psychopharmacol2011，14，5： | 1 |
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