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| 1 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 2 | Ambient UVB radiation causes deformities in amphibian embryos 显示文摘 | Blaustein A R Kiesecker J M Chivers D P | 1997 | Proc Nat Acad Sci USA1997，94，13： | 1 |
| 3 | Morphlogy of the gastroinlestinal tract in primates:comparision with the mammals in relation to diet显示文摘 | Chivers D J Hladic C M | 1980 | J Morpha1980，166，： | 1 |
| 4 | The sonocrystallisation of ice in sucrose solutions: primary and secondary nucleation 显示文摘 | CHOW R BL1NDT R CHIVERS R POVEYC M | 2003 | Ultrasonics2003，41，8： | 1 |
| 5 | Isola-tion has permanent effects upon the behavior of the rat, butnot the mouse, gerbil or guinea pig显示文摘 | EINON D F HUMPHREYS A P CHIVERS S M | 1981 | Developmental Psychobi-ology1981，14，4： | 1 |
| 6 | Effects of experimental water table and temperature manipu lations on ecosystem COz fluxes in an Alaskan rich fen显示文摘 | CHIVERS M R TURETSKY M R WADDINGTON J M | 2009 | Eco- systems2009，12，8： | 1 |
| 7 | Am- bient UVB radiation causes deformities in amphibian embryos 显示文摘 | BLAUSTEIN A R KIESECKER J M CHIVERS D P | 1997 | Proc Nat Acad Sei USA1997，94，13： | 1 |
| 8 | Effects of Experi- mental Water Table and Temperature Manipulations on Ecosys- tem CO2 Fluxes in an Alaskan Rich Fen显示文摘 | Chivers M Turetsky M Waddington J | 2009 | Ecosystems2009，12，8： | 1 |
| 9 | Chemical e- cology of predator-prey interactions in aquatic ecosys- tems: A review and prospectus 显示文摘 | Ferrari M C O Wisenden B D Chivers D P | 2010 | Canadian Journal of Zoology2010，88，7： | 1 |
| 10 | Im- paired learning of predators and lower prey survival under elevated CO2: A consequence of neurotransmitter interfer- ence 显示文摘 | Chivers D P Mccormick M I Nilsson G E | 2014 | Global Change Biology2014，20，2： | 1 |
| 11 | Conservative sharp debridement:the professional and legal issues显示文摘 | Ashworth J Chivers M | 2002 | Prof Nurse2002，17，5： | 1 |
| 12 | Synthetic and structural investigations of organomagnesium complexes of hybrid boraamidinate/ amidinate ligands and their use in the polymerization of rac - lactide 显示文摘 | Chivers T Fedorchuk C Parverz M | 2005 | Organometallics2005，24，： | 1 |
| 13 | Morphlogy of the Gastro in Lestinal Tract in Primates:Comparison with the Mammals in Relation to Diet显示文摘 | Chivers D J Hladic C M | 1980 | Morpha1980，166，： | 1 |
| 14 | Utility of percutaneous joint aspiration and synovial biopsy in identifying culture-positive infected hip arthroplasty 显示文摘 | Cross MC Kransdorf M J Chivers FS | 2014 | Skeletal Radiol2014，43，： | 1 |
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