|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | End-stage renal disease is associated with increased post endoscopic retrograde cholangiopancreatography adverse events in hospitalized patients显示文摘AIM To determine if end-stage renal disease (ESRD) is a risk factor for post endoscopic retrograde cholangio-pancreatography (ERCP) adverse events (AEs). METHODS We performed a retrospective cohort study using the Nationwide Inpatient Sample (NIS) 2011-2013. We identified adult patients who underwent ERCP using the International Classification of Diseases 9^(th) Revision (ICD-9-CM). Included patients were divided into three groups: ESRD, chronic kidney disease (CKD), and control. The primary outcome was post-ERCP AEs including pancreatitis, bleeding, and perforation determined based on specific ICD-9-CM codes. Secondary outcomes were length of hospital stay, in-hospital mortality, and admission cost. AEs and mortality were compared using multivariate logistic regression analysis.RESULTS There were 492175 discharges that underwent ERCP during the 3 years. The ESRD and CKD groups contained 7347 and 39403 hospitalizations respectively, whereas the control group had 445424 hospitalizations. Post-ERCP pancreatitis (PEP) was significantly higher in the ESRD group (8.3%) compared to the control group (4.6%) with adjusted odd ratio (aOR) = 1.7 (95% CI: 1.4-2.1, ~aP < 0.001). ESRD was associated with significantly higher ERCP-related bleeding (5.1%) compared to the control group 1.5% (aOR = 1.86, 95%CI: 1.4-2.4, ~aP < 0.001). ESRD had increased hospital mortality 7.1% vs 1.15% in the control OR = 6.6 (95%CI: 5.3-8.2, ~aP < 0.001), longer hospital stay with adjusted mean difference (aMD) = 5.9 d (95% CI: 5.0-6.7 d, ~aP < 0.001) and higher hospitalization charges aMD = $+82064 (95%CI: $68221-$95906, ~aP < 0.001). CONCLUSION ESRD is a risk factor for post-ERCP AEs and is associated with higher hospital mortality. Careful selection and close monitoring is warranted to improve outcomes. | Tarek Sawas Fateh Bazerbachi Samir Haffar Won K Cho Michael J Levy John A Martin Bret T Petersen Mark D Topazian Vinay Chandrasekhara Barham K Abu Dayyeh | 2018 | World Journal of Gastroenterology2018，24，41： | 2 |
| 3 | Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice显示文摘 | Satoh A Cho EJ | 2004 | J Pharm Pharmacol2004，56，： | 1 |
| 4 | Polyvinyl alcohol embolization of the inferior epigastric artery as treatment for abdominal wall hemorrhage from multiple sites complicating enoxaparin therapy显示文摘 | Semiz-Oysu A Moustafa T Cho K J | 2007 | European Journal of Radiology Extra2007，64，： | 1 |
| 5 | Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice显示文摘 | Yokozawa T Satoh A Cho EJ | 2004 | J Pharm Pharmacol2004，56，1： | 1 |
| 6 | Gross structure of a fault during its formation process in Westerly granite 显示文摘 | Kawakata H Cho A Yanagidani T | 2000 | Tectonophysics2000，，323： | 1 |
| 7 | Outcomes of a structured training programme for paediatric laparoscopic inguinal hernia repair 显示文摘 | Cho A Basson S Tsang T | 2013 | J Pediatr Surg2013，48，2： | 1 |
| 8 | Carbon formation on nickelandironoxide - containingoxygencarriersforchemical - looping combustion显示文摘 | Cho P Mattision T Lyngfeh A | 2005 | lnd Eng Chem Res2005，44，4： | 1 |
| 9 | Drug delivery to the brain by fo- cused ultrasound induced blood-brain barrier disruption: quantitative evaluation of enhanced permeability of cerebral vasculature using two- photon microscopy显示文摘 | Nhan T Burgess A Cho EE | 2013 | J Control Release2013，172，1： | 1 |
| 10 | Carbon formation on nickel and iron oxide-containing oxygen carriers for chemical-looping combustion显示文摘 | CHO P MATTISSON T LYNGFELT A | 2005 | Ind Eng Chem Res2005，44，4： | 1 |
| 11 | Reduced expression of dentin sialophosphoprotein is associated with dysplastic dentin in mice overexpressing transforming growth factor-beta 1 in teeth显示文摘 | Thyagarajan T Sreenath T Cho A | 2001 | J Biol Chem2001，276，11： | 1 |
| 12 | Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice 显示文摘 | Yokozawa T Satoh A Cho EJ | 2004 | J Pharm Pharmaco12004，56，1： | 1 |
| 13 | Prediction of The Combination of Failure Modes for An Arch Bridge System显示文摘 | Nowak A S Cho T | 2007 | Journal of Constructional Steel Research2007，63，12： | 1 |
| 14 | Reduced expression of dentin sialophosphoprotein is associated with dysplastic dentin in mice overexpressing transforming growth factor in teth 显示文摘 | Thyagarajan T Screenath T Cho A | 2001 | J Biol Chem2001，276，11： | 1 |
| 15 | Three-dimensional observations of faulting process in Westerly granite under uniaxial and triaxial conditions by X-ray CT scan显示文摘 | Cho A Kiyama T | 1999 | Tectonophysics1999，313，3： | 1 |
| 16 | Odontoblast-specific expression of cre recombinase successfully deletes gene segments flanked by loxP sites in mouse teeth显示文摘 | Sreenath TL Cho A Thyagarajan T | 2003 | Genesis2003，35，2： | 1 |
| 17 | Three- dimensional Observations of Faulting Process in Westerly Granite Under Uniaxial and Triaxial Conditions by X-ray CT Scan 显示文摘 | Kawakata H Cho A Yanagidani T | 1999 | Tectonophysics1999，313，： | 1 |
| 18 | MMP12,lung function, and COPD in high risk populations 显示文摘 | Hunninghake G M Cho M H Tesfaigzi Y Soto - Quiros M E Avila L Lasky - Su J Stidley C Melen E Soderhall C Hallberg J Kull I KercJ Svartengren M Pershagen G Wickman M Lange C Demeo D L Hersh C P Klanderman B J Raby B A Sparrow D Shapiro S D Silverman E K Litonjua A A Weiss S T Celedon J C | 2009 | New England Journal of Medicine2009，361，27： | 1 |
| 19 | Comparison of Iron-,Nickel-,Copperand Manganese-based Oxygen Carriers for Chemical-Looping Combustion显示文摘 | Cho P Mattisson T Lyngfelt A | 2004 | Fuel2004，83，9： | 1 |
| 20 | Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice显示文摘 | Yokozawa T Satoh A Cho EJ | 2004 | J Pharm Pharmacol2004，56，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员