|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | TNFα and reactive oxygen species in necrotic cell death显示文摘 | Michael J Morgan You-Sun Kim Zheng-gang Liu | 2008 | Cell Research2008，18，3： | 13 |
| 3 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 4 | Off-pump right atrial thrombectomy for heparin-induced thrombocytopenia with thrombosis显示文摘 | Jeffrey A Morgan Aftab R Kherani Deon W Vigilance Faisal H Cheema Nicholas J Colletti David I Sahar Kung-Ming Jan David L Diuguid Roman Nowygrod Mehmet C Oz Michael Argenziano | 2003 | The Annals of Thoracic Surgery2003，，2： | 1 |
| 5 | Sputum eosinophilia and short-term response to prednisolone in chronic obstructive pulmonary disease: a randomised controlled trial显示文摘 | Christopher E Brightling William Monteiro Richard Ward Debbie Parker Michael DL Morgan Andrew J Wardlaw Ian D Pavord | 2000 | The Lancet2000，，9240： | 1 |
| 6 | On the Effect of Hydrogen on Fracture Toughness of Steel显示文摘 | Kim Y Chao YJ Pechersky Marty J and Morgan Michael J | 2005 | International Journal of Fracture2005，134，34： | 1 |
| 7 | 使用表皮肌电监测来检测全面强直-阵挛发作显示文摘该前瞻性多中心Ⅲ期临床试验的目的在于评估在癫痫监测单元(Epilepsy monitoring unit,EMU)中使用可穿戴的表皮肌电图(surface electromyographic,s EMG)监测系统来检测全面强直-阵挛发作(Generalized tonic–clonic seizures,GTCS)的性能和耐受性。199例有GTCS病史的患者被收入11个Ⅳ级癫痫中心的EMU中,在进行临床视频脑电图(VEEG)监测的同时,也通过在肱二头肌上佩戴可穿戴设备接受了s EMG监测。所有s EMG数据记录都使用先前开发的检测算法在中心站点处理。将s EMG检测到的GTCS与3名评审专家验证的发作事件进行比较。在所有受试者中,检测算法共检测到了46次GTCS中的35次[76%,95%CI(0.61,0.87)],阳性预测值(Positive predictive value,PPV)为0.03,平均误报率(False alarm rate,FAR)为2.52/24 h。对于在肱二头肌中线上方记录到的数据,系统检测到了全部的29例GTCS[100%,95%CI(0.88,1.00)],检测时间平均延迟7.70 s,PPV为6.2%,平均FAR为1.44/24 h。28%(55/199)报告了轻至中度的不良事件,并导致9%的研究中止(17/199)。这些不良事件主要是电极贴片引起的皮肤刺激反应,这种情况未经治疗即可缓解。研究中无严重不良事件报告。在肱二头肌上使用s EMG监测装置来检测GTCS是可行的。正确放置该装置对于检测准确性至关重要,但是对于一些患者而言,减少误报数仍有一定难度。 | Jonathan J Halford Michael R Sperling Dileep R Nair 童馨 高慧 慕洁 Dlugos DJ Tatum WO Harvey J French JA Pollard JR Faught E Noe KH Henry TR Jetter GM Lie OV Morgan LC Girouard MR Cardenas DP Whitmire LE Cavazos JE | 2018 | 癫痫杂志2018，4，3： | 0 |
| 8 | Colonic Pseudo-obstruction: Contemporary Concepts and Practice显示文摘Acute colonic pseudo-obstruction is characterised by massive colonic distension without distal mechanical obstruction. It affects a wide variety of patients who often have multiple comorbidities, which makes studies on pseudoobstruction difficult to perform and interpret. Few advances have been made in recent years in our understanding and management, which remain challenging. This article explores and provides interpretation of the key studies and concepts that have shaped our management of this condition. | Michael K-Y Hong Catherine E Turner David N Blomberg Matthew J Morgan | 2017 | General Surgery2017，1，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员