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| 1 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 2 | The supply base and its complexity: Implications for transaction costs, risks, responsiveness, and innovation显示文摘 | Choi T Y Krause D R | 2006 | Journal of Operations Management2006，24，5： | 1 |
| 3 | Resurreccion,Consumer- Based Optimization of a Third-Generation Product Made from Peanut and Rice Flour 显示文摘 | I D Choi R D Phillips A V A | 2007 | Journal of Food Science2007，72，7： | 1 |
| 4 | Glu-tamate neurotoxicity in cortical cell culture显示文摘 | Choi D W Maulucci-Gedde M A Kriegste A R | 1987 | J Neurosci1987，7，： | 1 |
| 5 | Voltage sag compensation with energy optimized dynamic voltage restorer显示文摘 | VILATHGAMUWA D M PERERA A A D R CHOI S S | 2003 | IEEE Transactions on Power Delivery2003，18，3： | 1 |
| 6 | High catalytic activity of Pd2+-exchanged mesoporous sodalite and NaA zeolite for bulky aryls coupling:reusability under aerobic condition显示文摘 | Choi M Lee D H Na K Yu B W Ryoo R | | 0，，20： | 1 |
| 7 | 查看详情显示文摘 | Kang D Mead J Choi Y Farris R | | 0，，3： | 1 |
| 8 | CO2 utilization as an oxidant in the dehydrogenation of ethylbenzene to styrene over MnO2-ZrO2 catalysts显示文摘 | Burri D R Choi K W Han D | 2006 | Catalysis Today2006，115，14： | 1 |
| 9 | Cellular Structure of Peanut-based Extruded Snack Products Using Scanning Electron Microscopy显示文摘 | I D Choi R D Phillips H S Jeong | 2004 | Jonrnal of Texture Studies2004，35，： | 1 |
| 10 | Diferential induction and suppression of potato 3-hydroxy-3-methylglutaryl coenzyme A reductase genes in response to Phytophthora infestans and to its elicitor arachidonic acid显示文摘 | CHOI D WARD B L BOSTOCK R M | 1992 | Plant Cell1992，4，10： | 1 |
| 11 | Chapter 8 TiO2-based advanced oxidation nanotechnologies for water purification and reuse显示文摘 | CHOI H AL-ABED S R DIONYSIOU D D | 2010 | Sustainability Science & Engineering2010，2，9： | 1 |
| 12 | Calculation of mixed lubrica- tion at piston ring and cylinder liner interface 显示文摘 | CHO M R CHOI J K HAN D C | 2001 | KSME Inter- national Jouenal2001，15，7： | 1 |
| 13 | Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease 显示文摘 | Vijitruth R Liu M Choi D Y | 2006 | J Neuroinflammation2006，3，： | 1 |
| 14 | Modeling the effects of oxygenated fuels and split injections on DI diesel engine performance and emissions 显示文摘 | Choi C Y Reitz R D | 2000 | Combustion Science and Technology2000，159，： | 1 |
| 15 | Differential induction and suppression of potato 3-hydroxy-3-methylglutaryl coenzyme a reductase genes in response to Phytophora infestans and to its elicitor arechidonic acid显示文摘 | Choi D Ward B L Bostock R M | 1992 | Plant Cell1992，4，： | 1 |
| 16 | Development and thermal fatigue testing of ceramic thermal barrier coatings显示文摘 | Zhu D Choi S R Miller R A | 2004 | Surface and Coatings Technology2004，，1： | 1 |
| 17 | Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury显示文摘 | TENG Y D CHOI H ONARIO R C | 2004 | Proc Natl Acad Sci USA2004，101，9： | 1 |
| 18 | Banks and the world's major banking centers 显示文摘 | Choi S R Park D K Tschoegl A E | 1990 | Review of World Economics1990，132，： | 1 |
| 19 | A transmit preprocessing technique for multiuser MIMO systems using a decomposition approach 显示文摘 | Lai-U Choi Murch R D | 2004 | IEEE Transactions on Wireless Communications (S1536-1276)2004，3，1： | 1 |
| 20 | Efficiency droop due to electron spill-over and limited hole injection in Ⅲ-nitride visible light-emitting diodes employing lattice-matched InAlN electron blocking layers显示文摘 | Choi S Ji M H Kim J Kim H J Satter M M Yoder P D Ryou J H Dupuis R D Fischer A M Ponce F A | | 0，，16： | 1 |
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