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10239篇 您的检索式:作者名="Zhu D"
    题名 作者 年代 出处 被引量
12019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W 2020中华高血压杂志2020,28,3:516
2Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease显示文摘Tang B Xiong H Sun P Zhang Y Wang D Hu Z Zhu Z Ma H Pan Q Xia JH Xia K Zhang Z 2006中国生物学文摘2006,20,8:30
3Damage evolution and dynamic response of cement asphalt mortar layer of slab track under vehicle dynamic load显示文摘The damage evolution and dynamic performance of a cement asphalt(CA)mortar layer of slab track subjected to vehicle dynamic load is investigated in this paper.Initially,a statistical damage constitutive model for the CA mortar layer is developed using continuous damage mechanics and probability theory.In this model,the strength of the CA mortar elements is treated as a random variable,which follows the Weibull distribution.The inclusion of strain rate dependence affords considering its influence on the damage development and the transition between viscosity and elasticity.Comparisons with experimental data support the reliability of the model.A three-dimensional finite element(FE)model of a slab track is then created with the commercial software ABAQUS,where the devised model for the CA mortar is implemented as a user-defined material subroutine.Finally,a vertical vehicle model is coupled with the FE model of the slab track,through the wheel-rail contact forces,based on the nonlinear Hertzian contact theory.The evolution of the damage and of the dynamic performance of the CA mortar layer with various initial damage is investigated under the train and track interaction.The analysis indicates that the proposed model is capable of predicting the damage evolution of the CA mortar layer exposed to vehicle dynamic load.The dynamic compressive strain,the strain rate,and the induced damage increase significantly with an increase in the initial damage,whereas the dynamic compressive stress exhibits a sharp decrease with the increasing initial damage.Also,it is found that the strain rate dependence significantly influences the damage evolution and the dynamic behavior of the CA mortar layer.ZHU ShengYang FU Qiang CAI ChengBiao SPANOS Pol D 2014Science China(Technological Sciences)2014,57,10:19
4Out of southern East Asia: the natural history of domestic dogs across the world显示文摘Guo-Dong Wang Weiwei Zhai He-Chuan Yang Lu Wang LioZhong Yan-Hu Liu Ruo-Xi Fan Ting-Ting Yin Chun-Ling Zhu Andrei D Poyarkov David M Irwin Marjo K Hytonen Hannes Lohi Chung-I Wu Peter Savolainen Ya-Ping Zhang 2016Cell Research2016,26,1:16
5速溶山楂饮料对高脂血症患者血脂、抗氧化酶和免疫功能的作用显示文摘目的 探讨速溶山楂饮料调节高脂血症患者脂质紊乱、提高抗氧化酶活力和增强免疫功能的作用。方法 6 0名年龄 (5 7 9± 8 0 )岁高脂血症受试者 ,采用交叉试验方案 ,每名受试者参加 2次试验。半数受试者于第 1次试验补充速溶山楂饮料 (含 3g山楂干粉、相当于 30g鲜果 ,溶于 10 0ml水及饮料载体 ,1d 2次 ) ,另半数补充对照液 (0 75g瓜儿胶和少量淀粉作为饮料载体 ,1d 2次 )。持续 31d ,间隔 2 8d后 ,开始第 2次试验 ,受试者原补充速溶山楂饮料者 ,改为对照 ;原补充对照改为速溶山楂饮料。结果 补充速溶山楂饮料能显著降低血清总胆固醇 (9 6 % )、甘油三酯 (12 1% )、低密度脂蛋白 (18% ) ;而明显增加超氧化物歧化酶 (SOD)活力 (7 5 % )水平。受试者补充含瓜儿胶对照液虽然对某些血清脂质也有一定的改善作用 ,但效果不如速溶山楂饮料显著 ;而且 ,受试者仅在补充速溶山楂饮料时血清甘油三酯水平显著降低、抗氧化酶SOD水平显著提高 ,补充对照液无作用。结论 补充速溶山楂饮料能有效降低血清总胆固醇、甘油三酯、低密度脂蛋白、丙二醛水平 ,升高ApoA Ⅰ水平、SOD活性和NK细胞活力 ;综合测试表明 :补充速溶山楂饮料和对照比 ,调整血脂、提高抗氧化酶活力效果更显著。陈吉棣 薛彬 李可基 拾景达 Krempin D Zhu M Garland C 2002中华预防医学杂志2002,36,3:11
6Structure and Property of Bamboo Fiber显示文摘The chemical composition, fiber characteristics, crystalline structure, mechanical properties and thermal behavior of the five species of bamboo (Phyllostachys edulis cv.Pachyloe, Bambusa tootisk, Arundinaia amabilis, B.vulgaris cv. Vittata, and Dendrocalamus affinis) were studied with IR, X-ray, DSC and chemical analyses. The results indicated that the benzene-ethanol extractive content of bamboo was higher than that of wood, the content of lignin and the content of pentosan were 19.1% - 25.3% and 14.9% - 22.6%, respectively. Except for Ph. edulis cv. Pachyloe, the cellulose content in the other 4 species was over 50%. The average length of fiber of D. affinis was the longest (1.861 mm). The length/ width ratio of bamboo fiber was also higher than that of wood, and it was the highest for B.tootisk, which reached 142. The results of IR and X-ray confirmed that crystalline structure of bamboo fibers was cellulose, and A. amabilis had the highest crystallinity index. The differential thermal analysis (DSC) can be one of the methods to identify various fiber materials. After steam explosive pretreatment, cellulose content of D. affinis had increased from 50.5% to 69.2%, the crystallinity index had increased and the breaking tenacity of bamboo fibers was suitable for producing textile products, indicating that steam explosion is an useful pretreatment for bamboo fibers made into composite materials and textiles.JIANG Jianxin1 YANG Zhongkai2 ZHU Liwei1 SHI Limin2 YAN Lijie1 1. College of Materials Science and Technology, Beijing Forestry University, Beijing100083, P. R. China 2 .Beijing Municipal Key Laboratory of Clothing Materials R & D and Assessment, Beijing Institute of Clothing Technology, Beijing 100029, P. R. China. 2008Chinese Forestry Science and Technology2008,7,2:8
7Effects of somatostatin on splanchnic hemodynamics in cirrhotic patients with portal hypertension显示文摘INTRODUCTIONEsophageal variceal bleeding (EVB) is one of themost common complications of cirrhosis with portalhypertension.In recent years,great progress hasbeen made in medicinal treatment.Somatostatin hasbeen widely used in clinics,for it can effectivelylower the portal venous pressure (PVP) withZhu JY Leng XS Wang D Du RY 2000World Journal of Gastroenterology2000,6,1:7
8A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software packageYU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden 2001Chinese Science Bulletin2001,46,23:6
9Enhancing disease resistances of Super Hybrid Rice with four antifungal genes显示文摘A plant expression vector harboring four antifungal genes was delivered into the embryogenic calli of ‘9311’, an indica restorer line of Super Hybrid Rice, via modified biolistic particle bombardment. Southern blot analysis indicated that in the regenerated hygromycin-resistant plants, all the four anti-fungal genes, including RCH10, RAC22, β-Glu and B-RIP, were integrated into the genome of ‘9311’, co-transmitted altogether with the marker gene hpt in a Mendelian pattern. Some transgenic R1 and R2 progenies, with all transgenes displaying a normal expression level in the Northern blot analysis, showed high resistance to Magnaporthe grisea when tested in the typical blast nurseries located in Yanxi and Sanya respectively. Furthermore, transgenic F1 plants, resulting from a cross of R2 homo-zygous lines with high resistance to rice blast with the non-transgenic male sterile line Peiai 64S, showed not only high resistance to M. grisea but also enhanced resistance to rice false smut (a disease caused by Ustilaginoidea virens) and rice kernel smut (another disease caused by Tilletia barclayana).ZHU HuaChen1, XU XinPing1, XIAO GuoYing2,3, YUAN LongPing2 & LI BaoJian1 1 Biotechnology Research Center, Key Laboratory of Gene Engineering of Ministry of Education, Sun Yat-sen University, Guangzhou 510275, China 2 China National Hybrid Rice R&D Center, Hunan Hybrid Rice Research Center, Changsha 410125, China 3 Institute of Subtropical Agriculture, the Chinese Academy of Sciences, Changsha 410125, China 2007Science China(Life Sciences)2007,50,1:6
10Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells显示文摘Saiyong Zhu Raiesh Ambasudhan Woong Sun Hyun Jung Kim Maria Talantova Xiaojing Wang Mingliang Zhang Yu Zhang Timothy Laurent James Parker Han-Seop Kim Jeffrey D Zaremba Sofiyan Saleem Sara Sanz-Blasco Eliezer Masliah Scott R McKercher Yee Sook Cho Stuart A Lipton Janghwan Kim Sheng Ding 2014Cell Research2014,24,1:6
11血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J 2019中华高血压杂志2019,27,5:6
12Osteopontin protects against hyperoxia-induced lung injury by inhibiting nitric oxide synthases显示文摘到超过 95% O_2 的成年老鼠的背景暴露到 72 个小时生产致命的损害。氮的氧化物 synthase (NOS ) 被认为贡献鼠科的导致 hyperoxia 的尖锐的肺损害(ALI ) 的 pathophysiology。Osteopontin (OPN ) 是巨噬细胞主要生产的 phosphorylated glycoprotein。OPN 禁止可诱导的氮的氧化物 synthase (iNOS ) ,它产生大量氮的氧化物生产。然而,在氮的氧化物之间的关系和在肺织物的内长的 OPN 还没在 导致hyperoxia 的 ALI 期间被阐明了,因此,我们检验了 OPN 在有 NOS.Methods 的 导致hyperoxia 的肺损害和它的关系起的作用 144 只 osteopontin 大美人(击倒)老鼠和他们的匹配的野类型背景控制( WT )在封上的笼子被暴露>为 24-72 小时的95%氧或房间空气,并且肺损害的严厉被估计;OPN 的表示, endothelial 氮的氧化物 synthase (eNOS ) 和在在 hyperoxia 的 24,48 和 72 个小时的肺纸巾的 iNOS mRNA 被反向的抄写聚合酶链反应(RT-PCR ) 学习;immunohistochemistry (IHC ) 被执行因为在肺 tissues.Results OPN 击倒老鼠的 iNOS, eNOS,和 OPN 蛋白质的察觉在 72 小时 hyperoxia 开发了更严重的尖锐的肺损害。湿 / 干燥的重量比率增加了到 6.ZHANG Xiang-feng LIU Shuang ZHOU Yu-jie ZHU Guang-fa Hussein. D Foda 2010Chinese Medical Journal2010,,7:4
13Improvement of electrochemical machining accuracy by using dual pole tool 显示文摘Zhu D Xu H Y 2002Journal of Materials Processing Technology2002,129,1:2
14Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy显示文摘Sinha Rohit Anthony You Seo-Hee Zhou Jin Siddique Mobin M Bay Boon-Huat Zhu Xuguang Privalsky Martin L Cheng Sheue-Yann Stevens Robert D Summers Scott A Newgard Christopher B Lazar Mitchell A Yen Paul M 2012EN2012,,7:2
15Reconfiguring the Logical Topology With Performance Guarantees in WDM Networks显示文摘To improve the network performance after traffic demand changes, reconfiguring the logical topology is necessary. We present an ILP algorithm to find out the least lightpath changes needed with guaranteed network performance.Fengqing Liu, Qingji Zeng, Xu Zhu, Xudong YangR&D Center for Broadband Optical Networking Techonology.Shanghai Jiaotong University Shanghai 200030, P.R. China, Tel: +86-21-62932166, Fax: +86-21-62932166, E-mail:liufengqing_1975@sjtu.edu.cn 2003光学学报2003,23,S1:2
16Bacterial leaching of heavy metals from sewage for argricultural application 显示文摘Couill D Shucal Zhu 1990Water Air Soil Pollut1990,63,:2
17Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds.Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan 2017Science China(Physics,Mechanics & Astronomy)2017,60,6:2
18Co-coercivity and its role in the convergence of iterative schemes for solving variational inequalities显示文摘Zhu D L Marcotte P 1996SIAM J Optim1996,6,3:2
19Integrated dynamic wet spinning of core-sheath hydrogel fibers for optical-to-brain/tissue communications显示文摘Hydrogel optical light-guides have received substantial interest for applications such as deep-tissue biosensors,optogenetic stimulation and photomedicine due to their biocompatibility,(micro)structure control and tissue-like Young’s modulus.However,despite recent developments,large-scale fabrication with a continuous synthetic methodology,which could produce core-sheath hydrogel fibers with the desired optical and mechanical properties suitable for deep-tissue applications,has yet to be achieved.In this study,we report a versatile concept of integrated light-triggered dynamic wet spinning capable of continuously producing core-sheath hydrogel optical fibers with tunable fiber diameters,and mechanical and optical propagation properties.Furthermore,this concept also exhibited versatility for various kinds of core-sheath functional fibers.The wet spinning synthetic procedure and fabrication process were optimized with the rational design of the core/sheath material interface compatibility[core=poly(ethylene glycol diacrylate-co-acrylamide);sheath=Ca-alginate],optical transparency,refractive index and spinning solution viscosity.The resulting hydrogel optical fibers exhibited desirable low optical attenuation(0.18±0.01 d B cm^(-1) with 650 nm laser light),excellent biocompatibility and tissue-like Young’s modulus(<2.60 MPa).The optical waveguide hydrogel fibers were successfully employed for deep-tissue cancer therapy and brain optogenetic stimulation,confirming that they could serve as an efficient versatile tool for diverse deep-tissue therapy and brain optogenetic applications.Guoyin Chen Gang Wang Xinrong Tan Kai Hou Qingshuo Meng Peng Zhao Shun Wang Jiayi Zhang Zhan Zhou Tao Chen Yanhua Cheng D Benjamin S.Hsiao Elsa Reichmanis Meifang Zhu 2021National Science Review2021,8,9:2
20Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu 2014Cell Research2014,24,5:2
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