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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Information needs of older people with heart failure: listening to their own voice显示文摘 | Ming-Ming YU Sek Ying Chair Carmen WH Chan Kai Chow Choi | 2016 | Journal of Geriatric Cardiology2016，13，5： | 2 |
| 3 | Fibrous dysplasia : MR imaging char- acteristics with radiopathologic correlation显示文摘 | Jee WH Choi KH Choe BY | 1996 | Am J Roentgeno[1996，167，6： | 1 |
| 4 | Curcumin attenuates adhesion molecules and matrix metalloproteinase expression in hy- percholesterolemic rabbits 显示文摘 | Um MY Hwang KH Choi WH | 2014 | Nutr Res2014，34，10： | 1 |
| 5 | A novel chemokine,Leukotactin-1,induces chemotaxis,pro-atherogenic cytokines,and tissue factor expression in atherosclerosis显示文摘 | Lee WH Kim SH Jeong EM Choi YH Kim DI Lee B | 2002 | Atherosclerosis2002，161，2： | 1 |
| 6 | Compact cysteine- coated CdSe ( ZnCdS ) quantum dots for in vivo applications显示文摘 | Liu WH Choi HS Zimmer JP | 2007 | J Am Chem Soc2007，129，14： | 1 |
| 7 | Anti-invasive activity of sanguinarina through modulation oftight junctions and matrix metalloproteinase activities in MDA-MB-231 human breast carcinoma cells显示文摘 | Choi YH Choi WY Hong SH Kim SO Kim GY Lee WH | 2009 | Chem Biol Interact2009，179，23： | 1 |
| 8 | Objective Criteria of Triangular Cord Sign in Biliary Atresia on US Scans 显示文摘 | Lee HJ Lee SM Park WH Choi SO | 2003 | Radiology2003，229，2： | 1 |
| 9 | 'Triangular cord: a sono- graphic finding applicable in the diagonosis of biliary atresia 显示文摘 | Choi S Park WH Lee H J | 1996 | J Pediatr Surg1996，31，3： | 1 |
| 10 | Ethyl gallate induces apoptosis of HL - 60 cells by promoting the expression of caspases - 8, - 9, - 3, apoptosisinducing factor and endonuclease G 显示文摘 | Kim WH Song HO Choi HJ | 2012 | Int J mol Sci2012，13，11： | 1 |
| 11 | Clinical usefulness of extratym panic electrocochleography in the diagnosis of Meniere's disease 显示文摘 | Chung WH Cho DY Choi JY | 2004 | Otol Neurotol2004，5，3： | 1 |
| 12 | Asympomatic brain lesions in pilots: a comparative study with non-flying personnel using brain MRI显示文摘 | Lira D Park J Choi WH | 2012 | Aviat Space Environ Med2012，83，9： | 1 |
| 13 | 'Triangular cord':a sonographic finding applicable in the diagnosis of biliary atresia显示文摘 | Choi SO Park WH Lee HJ | 1996 | J Pediatr Surg1996，31，3： | 1 |
| 14 | A survival prediction model of rats in hemorrhagic shock using the random forest classifier显示文摘 | Choi JY Kim SK Lee WH | 2012 | Conf Proc IEEE Eng Med Biol Soc2012，2012，： | 1 |
| 15 | Dentofacial characteristics in or?thodontic patients with centric relation-maximum intercuspation dis?crepancy显示文摘 | Lim WH Choi B Lee JY | 2014 | Angle Orthod2014，84，6： | 1 |
| 16 | Effects of EGb 761 and Korean Red Ginseng on Melanogenesis in B16F10 Melanoma Cells and Protection Against UVB Irradiation in Murine Skin 显示文摘 | Han SK Choi WH Ann HS | 2008 | Molecular & Cellular Toxicology2008，4，1： | 1 |
| 17 | Brassiere wearing and breast cancer risk:A systematic review and meta-analysis显示文摘AIM:To evaluate existing evidence for the association between different type of brassiere exposures and the risk of breast cancer.METHODS:Ovid Medline,CINAHL,Cochrane Data Base of Systematic Reviews,Pubmed,Scopus,Proquest,Sciencedirect,Wiley Online Library,WanF ang Data,Hong Kong Index to Chinese Periodicals,China Journal Net,Chinese Medical Current Contents,Chinese Biomedical Literature Database,China Academic Journals FullText database,Taiwan Electronic Periodical Services and HyR ead; reference lists of published studies; original research studies published in English or Chinese examining the association between type and duration of brassiere-wearing and breast cancer risk.Data were abstracted by a first reviewer and verified by a second.Study quality was rated according to predefined criteria.'Fair' or 'good' quality studies were included.Results were summarised by meta-analysis whenever adequate material was available.RESULTS:Twelve case-control studies were included in the review.Meta-analysis showed brassiere wearing during sleep was associated with a 1.3 times of increased risk.The odd ratio for more than 12 h of daily brassiere use in relation to breast cancer risk was 1.08(95%CI:1.01-1.14).CONCLUSION:The present review demonstrates insufficient evidence to establish a positive association between the duration and type of brassiere wearing and breast cancer.Further research is essential; specifically,a large-scale epidemiological study of a better design is needed to examine the association between various forms of brassiere exposure in detail and breast cancer risk,with adequate control of confounding variables. | Winnie KW So Dorothy NS Chan Yan Lou Kai-Chow Choi Carmen WH Chan Kristina Shin Ava Kwong Diana TF Lee | 2015 | World Journal of Meta-Analysis2015，3，4： | 1 |
| 18 | Protective effect of polygonum multiflorum Thunb on amyloid beta-peptide 25-35 induced cognitive deficits in mice 显示文摘 | Um MY Choi WH Aan JY | 2006 | J Ethnopharma2006，104，2： | 1 |
| 19 | Penile vibratory threshold changes with various doses of SS-cream in patients with primary premature ejaculation 显示文摘 | Xin ZC Choi YD Lee WH | 2000 | Yonsei Med J2000，41，1： | 1 |
| 20 | Involvement of p21WAF1/CIPI,pRB,Bax and NF-kappaB in induction of growth arrest and apoptosis by resveratrol in human lung carcinoma A549 CELLS显示文摘 | Kim YA Lee WH Choi TH | 2003 | Int J Oncol2003，23，4： | 1 |
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