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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Angiogenic and lymphangiogenic microvessel density in breast carcino- ma: correlation with clinicopathologic parameters and VEGF-family gene expression 显示文摘 | Choi WW Lewis MM Lawson D | 2009 | Mod Pathol2009，18，1： | 1 |
| 3 | A new immunostain al- gorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy显示文摘 | Choi WW Weisenburger DD Greiner TC | 2009 | Clin Cancer Res2009，15，17： | 1 |
| 4 | Angiogenic and lymphangiogenic microvessel density in breast carcinoma:correlation with clinicopathologic parameters and VEGF-family gene expression显示文摘 | Choi WW Lewis MM Lawson D | 2005 | Mod Pathol2005，18，1： | 1 |
| 5 | A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy 显示文摘 | Choi WW Weisenburger DD Greiner TC | 2009 | Clin Cancer Res2009，15，17： | 1 |
| 6 | Angiogenic and lymphangiogenic microvessel density in breast carcinoma:correlation with clinicopathologic parameters and VEGFfamily gene expression显示文摘 | Choi WW Lewis MM Lawson D | 2005 | Mod Pathol2005，18，1： | 1 |
| 7 | Angiogenic and lymphangiogenic mierovessel density in breast carcinoma:correlation with clinicopathologic parame- ters and VEGF- family gene expression 显示文摘 | Choi WW Lewis MM Lawson D | 2009 | Mod Pathol2009，18，1： | 1 |
| 8 | Addition of rituximab to standard chemotherapy improves the survival of both the germinal center B-cell-like and non-germinal center B-cell-like subtypes of diffuse large B-cell lymphoma 显示文摘 | Fu K Weisenburger DD Choi WW | 2008 | J Clin Oncol2008，26，28： | 1 |
| 9 | Angiogenic and lymphangiogenic microvessel density in breast carcinoma:correlationwith clinicopathologic parameters and VEGF-family gene ex-pression显示文摘 | Choi WW Lewis MM Lawson D | 2005 | Mod Pathol2005，18，1： | 1 |
| 10 | Angiogenic and Lymph angiogenic microvessel density in breast carcinoma:correl-ation with clinical pathologic parameters and VEGF-family gene expression显示文摘 | Choi WW Lewis MM Lawson D | 2005 | Med Pathol2005，18，： | 1 |
| 11 | Computer-assisted fluoroscopic targeting system for pedicle screw insertion 显示文摘 | Choi WW Green BA Levi ADO | 2000 | Neurosurgery2000，47，4： | 1 |
| 12 | Regulating human Th17 cells via differential expression of IL-1 receptor 显示文摘 | Lee WW Kang SW Choi J | 2010 | Blood2010，115，3： | 1 |
| 13 | A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy显示文摘 | Choi WW Weisenburger DD Greiner TC | 2009 | Clin Cancer Res2009，15，： | 1 |
| 14 | Angiogenic and lymphangio- genic microvessel density in breast carinoma:correlation with clini- copathologic parameters and VEGF - family gene expression 显示文摘 | Choi WW Lewis MM Lawson D | 2009 | Mod Patho12009，18，1： | 1 |
| 15 | Angiogenic and lymphangiogenic microvessel density in breast carcino- ma:correlation with clinicopathologic parameters and VEGF family gene expression 显示文摘 | Choi WW Lewis MM Lawson D | 2005 | Mod Pathol2005，18，1： | 1 |
| 16 | Temporary increaseof PPAR-y and transient expression of UCP-1 instromal vascular raction isolated human adipocytederived stem cells during adipogenesis显示文摘 | Jo SJ Choi WW Lee ES | 2011 | Lipids2011，46，6： | 1 |
| 17 | Angiogenic and lymphangiogenic microvessel density in breast carcinoma:correlation with clinicopathologic parameters and VEGF-family gene expression显示文摘 | Choi WW Lewis MM Lawson D | 2005 | Mod Pathol2005，18，1： | 1 |
| 18 | Effects of acute hypermagnesemia on the threshold for lidocaine-induced seizures in the rat显示文摘 | Choi WW Warner DS Monahan D J | 1991 | Am J Obstet Gynecol1991，164，2： | 1 |
| 19 | Angiogenic and lymphangiogenic microvessel density in breast carcinoma:correlation with clinicopathologic parameters and VEGF-family gene expression显示文摘 | Choi WW Lewis MM Lawson D | 2005 | Mod Pathol2005，18，1： | 1 |
| 20 | Addition of rituximab to standard chemotherapy improves the survival of both the germinal center B-cell- like and non-germinal center B-cell- like subtypes of diffuse large B-cell lymphoma显示文摘 | Fu K Weisenburger DD Choi WW | 2008 | J C/in Oncol2008，26，28： | 1 |
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