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5篇 您的检索式：作者名="Chong Hak Chae"

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		题名	作者	年代	出处	被引量
	1	HER-2/neu Amplification Is an Independent Prognostic Factor in Gastric Cancer显示文摘	Dong Il Park Jung Won Yun Jung Ho Park Suk Joong Oh Hong Joo Kim Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim Chang Hak Yoo Byung Ho Son Eun Yoon Cho Seoung Wan Chae Eo-Jin Kim Jin Hee Sohn Seung Ho Ryu Antonia R. Sepulveda	2006	Digestive Diseases and Sciences2006，，8：	1
	2	HER-2/neu Amplification Is an Independent Prognostic Factor in Gastric Cancer显示文摘	Dong Il Park Jung Won Yun Jung Ho Park Suk Joong Oh Hong Joo Kim Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim Chang Hak Yoo Byung Ho Son Eun Yoon Cho Seoung Wan Chae Eo-Jin Kim Jin Hee Sohn Seung Ho Ryu Antonia R. Sepulveda	2006	Digestive Diseases and Sciences2006，，8：	1
	3	HER-2 / neu Amplification Is an Independent Prognostic Factor in Gastric Cancer显示文摘	Dong Il Park Jung Won Yun Jung Ho Park Suk Joong Oh Hong Joo Kim Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim Chang Hak Yoo Byung Ho Son Eun Yoon Cho Seoung Wan Chae Eo-Jin Kim Jin Hee Sohn Seung Ho Ryu Antonia R. Sepulveda	2006	Digestive Diseases and Sciences2006，，8：	1
	4	HER-2/neu Amplification Is an Independent Prognostic Factor in Gastric Cancer显示文摘	Dong Il Park Jung Won Yun Jung Ho Park Suk Joong Oh Hong Joo Kim Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim Chang Hak Yoo Byung Ho Son Eun Yoon Cho Seoung Wan Chae Eo-Jin Kim Jin Hee Sohn Seung Ho Ryu Antonia R. Sepulveda	2006	Digestive Diseases and Sciences2006，，8：	1
	5	A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway显示文摘Interleukin-1 receptor-associated kinase 4(IRAK4)is a pivotal enzyme in the Toll-like receptor(TLR)/MYD88 dependent signaling pathway,which is highly activated in rheumatoid arthritis tissues and activated B cell-like diffuse large B-cell lymphoma(ABC-DLBCL).Inflammatory responses followed by IRAK4 activation promote B-cell proliferation and aggressiveness of lymphoma.Moreover,proviral integration site for Moloney murine leukemia virus 1(PIM1)functions as an anti-apoptotic kinase in propagation of ABC-DLBCL with ibrutinib resistance.We developed a dual IRAK4/PIM1 inhibitor KIC-0101 that potently suppresses the NF-κB pathway and proinflammatory cytokine induction in vitro and in vivo.In rheumatoid arthritis mouse models,treatment with KIC-0101 significantly ameliorated cartilage damage and inflammation.KIC-0101 inhibited the nuclear translocation of NF-κB and activation of JAK/STAT pathway in ABC-DLBCLs.In addition,KIC-0101 exhibited an anti-tumor effect on ibrutinib-resistant cells by synergistic dual suppression of TLR/MYD88-mediated NF-κB pathway and PIM1 kinase.Our results suggest that KIC-0101 is a promising drug candidate for autoimmune diseases and ibrutinib-resistant B-cell lymphomas.	Sae-Bom Yoon Hyowon Hong Hee-Jong Lim Ji Hye Choi Yoon Pyo Choi Seong Wook Seo Hyuk Woo Lee Chong Hak Chae Woo-Kyu Park Hyun Young Kim Daeyoung Jeong Tran Quang De Chang-Seon Myung Heeyeong Cho	2023	Acta Pharmaceutica Sinica B2023，13，3：	0

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