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您的检索式：作者名="Chongkai Gao"
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| 1 | Pipe-assembly approach for ships using modified NSGA-Ⅱ algorithm显示文摘Pipe-routing for ship is formulated as searching for the near-optimal pipe paths while meeting certain objectives in an environment scattered with obstacles. Due to the complex construction in layout space, the great number of pipelines, numerous and diverse design constraints and large amount of obstacles, finding the optimum route of ship pipes is a complicated and time-consuming process. A modified NSGA-Ⅱ algorithm based approach is proposed to find the near-optimal solution to solve the problem. By simplified equipment models, the layout space is firstly divided into three dimensional(3D) grids to build its mathematical model. In the modified NSGA-Ⅱ algorithm, the concept of auxiliary point is introduced to improve the search range of maze algorithm(MA) as well as to guarantee the diversity of chromosomes in initial population. Then the fix-length coding mechanism is proposed, Fuzzy set theory is also adopted to select the optimal solution in Pareto solutions. Finally, the effectiveness and efficiency of the proposed approach is demonstrated by the contrast test and simulation. The merit of the proposed algorithm lies in that it can provide more appropriate solutions for the designers while subject certain constrains. | Sui Haiteng Niu Wentie Niu Yaxiao Zhou Chongkai Gao Weigao | 2016 | Computer Aided Drafting,Design and Manufacturing2016，26，2： | 2 |
| 2 | Preparation and pharmacokinetic study of fenofibrate cubic liquid crystalline显示文摘An LCC delivery system for Fenofibrate (Fen) was developed to improve its poorly oral bioavailability. Fen-LCC preparation methods were screened, and the prepared Fen-LCC was then characterized by a polarizing microscope and transmission electron microscopy (TEM).The spray drying technique was selected to dry and solidify particles into powder. The in vitro release of Fen-LCC was measured and in vivo pharmacokinetic experiments were carried out on rats after oral administration. Particles prepared through the high-temperature input method exhibited structural characteristics of LCC, and re-dissolved particles maintained the same features. The LCC delivery system can significantly improve in vitro release outcomes. After oral administration, AUCs of the suspension and LCC systems were measured at 131.6853 μg·h/ml and 1435.72893 μg·h/ml, respectively. The spray drying process presented here better maintains cubic structures, and the LCC system significantly improves bioavailability levels. | Shijie Wei Jingbo Ren Ning Li Wuzhen Huo Chongkai Gao | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，6： | 1 |
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