|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Whole brain radiotherapy for the treatment of multiple brain metastases显示文摘 | Tsao M Lloyd N Wong R Chow E Rakovitch E Laperriere N | 2006 | 中国神经肿瘤杂志2006，4，2： | 17 |
| 2 | 罗格列酮与全反式维甲酸联合对骨髓瘤细胞增殖抑制作用及其机制探讨显示文摘目的探讨罗格列酮(RGZ)与全反式维甲酸(ATRA)在体内外对骨髓瘤细胞生长的影响及其作用途径。方法用RG2和ATRA单独或联合处理多发性骨髓瘤细胞系U266和RPMI8226细胞,采用^1H—TdR掺入法检测细胞增殖变化;Annexin—V和PI双染后采用流式细胞术检测细胞凋亡;用半定量RT-PCR方法检测凋亡抑制基因FLIP、XIAP及survivin mRNA表达变化;采用荧光CaspACE试剂盒检测caspase-3活性变化;采用裸鼠体内成瘤试验观察骨髓瘤细胞在动物体内生长情况。结果RGZ对骨髓瘤细胞具有增殖抑制作用,且呈剂量依赖关系(U266组r=0.991,P〈0.01;RPMI8226组r=0.961,P〈0.01);与RGZ单用组比较,ATRA与RGZ联合对骨髓瘤细胞的增殖抑制作用更明显(U266组P〈0.001;RPMI8226组P〈0.01);10μmol/L的RGZ处理组U266细胞凋亡率为(9.8±1.7)%,RPMI8226细胞凋亡率为(10.7±3.3)%,且诱导凋亡作用呈时间、剂量依赖性,ATRA与RGZ联合应用时,凋亡细胞的比例较相应的RGZ单独处理组显著升高(P值均〈0.01);RGZ能抑制FLIP、XIAP及survivin mRNA的表达,ATRA能协同RGZ进一步抑制FLIP、XIAP及survivin mRNA的表达;经RGZ处理的骨髓瘤细胞caspase-3活性显著增加,RGZ与ATRA联合处理后caspase-3活性较RGZ处理组显著增加(P〈0.01);RGZ可明显抑制骨髓瘤细胞在裸鼠体内的生长(P〈0.001),并且ATRA与RGZ联合能增强RGZ在裸鼠体内对骨髓瘤细胞生长的抑制作用(P〈0.01)。结论RGZ能通过抑制FLIP、XIAP及survivin的表达、促进caspase-3的活化从而诱导细胞凋亡,抑制细胞增殖。ATRA能增强RGZ对骨髓瘤细胞的上述作用,两者联合具有协同效应。 | 黄海雯 吴德沛 陈广华 常惠荣 Chow HCH Leung AYH Liang R | 2009 | 中华血液学杂志2009，30，4： | 5 |
| 3 | Metallothionein 2A expression is associated with cell proliferation in breast cancer显示文摘 | Jin R Chow V T Tan P H | 2002 | Carcinogenesis2002，23，1： | 2 |
| 4 | Finite element analysis of tunnel-soil-pile interaction using displacement controlled model显示文摘 | CHENG C Y DASARI G R CHOW Y K | 2007 | Tunnelling and Underground Space Technology2007，22，4： | 1 |
| 5 | Abscisic acid inhibits type 2C protein phosphatases via the PYR/ PYL family of START proteins显示文摘 | PARK S Y FUNG P NISHIMURA N JENSEN D R FFUJII ZHAO Y LUMBA S SANTIAGO J RODRIGUES A CHOW T F | 2009 | Science2009，324，： | 1 |
| 6 | Structure-property relations in processing high-performance polyisoimide-imide resins显示文摘 | CHOW A W HAMLIN R D LANDIS A L | 1992 | Journal of Rheology1992，36，8： | 1 |
| 7 | Purification and characterization of an extracellular laccase from the anthracene-degrading fungus Fusarium solani MAS2 显示文摘 | WU Y R LUO Z H KWOK-KEI CHOW R | 2010 | Bioresour Technol2010，101，24： | 1 |
| 8 | Single breath- hold diffusion- weighted imaging of the abdomen 显示文摘 | Chow LC Bammer R Moseley ME | 2003 | I Magn Reson Imaging2003，18，： | 1 |
| 9 | Leptin signaling in the hypothalamus of normal rats in vivo显示文摘 | Mccowen K C Chow J C and Smith R J | 1998 | Endocrinology1998，139，11： | 1 |
| 10 | Surface roughness and its effects on the heat transfer mechanism in spray cooling 显示文摘 | Pais M R Chow L C Mathefdey E T | 1992 | ASME Journal of Heat Transfer1992，114，1： | 1 |
| 11 | Major depressive disorder in adolescence: a brief review of the recent treatment 显示文摘 | Millin R Walker S Chow J | 2003 | The Canadian Journal of Psychiatry2003，48，9： | 1 |
| 12 | Moisture absorption studies of sisal fibre reinforced polypropylene composites 显示文摘 | C P L Chow X S Xing R k Y Li | 2007 | Composites science and technology2007，67，： | 1 |
| 13 | Finite element analysis of tunnel-soil-pile interaction using displacement controlled model显示文摘 | Cheng C Y Dasari G R Chow Y K | 2007 | Tunnelling and Underground Space Technology2007，22，4： | 1 |
| 14 | The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamate/glutamine levels and is important for growth in vivo显示文摘 | Cowley S Ko M Pick N Chow R Downing KJ Gordhan BG Betts JC Mizrahi V Smith DA Stokes RW Av-Gay Y | 2004 | Mol Microbiol2004，52，6： | 1 |
| 15 | Iterative methods for a fourth order boundary value problem显示文摘 | Agarwal R P Chow Y M | 1984 | J Comput Appl Math1984，10，： | 1 |
| 16 | Effects of spray characteristics on critical heat flux in subcooled water spray cooling 显示文摘 | Chen R H Chow L C Navedo J E | 2002 | International Journal of Heat and Mass Transfer2002，45，19： | 1 |
| 17 | Validating evapotranspiraiton equations using Bowen Ratio in New Brunswick, Maritime, Canada 显示文摘 | XING Z H CHOW L E MENG F R | 2008 | Sensors2008，8，： | 1 |
| 18 | Networked Control System: Overview and Research Trends显示文摘 | Gupta R A Chow M Y | 2010 | IEEE Transactions on Industrial Electronics2010，57，7： | 1 |
| 19 | Iterative method for fourth order boundary value problem显示文摘 | Agarwal R P Chow Y M | 1984 | J Comput App Math1984，10，： | 1 |
| 20 | Wireless electrochemical DNA microarray sensor显示文摘 | Chow K F Mavre F 0 Crooks R M | 2008 | Journal of the American Chemical Society2008，130，24： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员