|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Alcohol consumption and cigarette smoking increase the frequency of p53 mutations in non-small cell lung cancer显示文摘 | Ahrendt SA Chow JT Yang SC | 2000 | Cancer Research2000，60，12： | 1 |
| 3 | Rapid p53 sequence analysis in primary lung cancer using an oligonucleotide probe array 显示文摘 | Ahrendt SA Halachmi S Chow JT | 1999 | Proc Natl Acad Sic USA1999，96，13： | 1 |
| 4 | Multiplex PCR for detection of aminoglycoside resistance genes in enterococci 显示文摘 | Chow JW Lemer SA Zervos MJ | 2003 | Antimicrob Agents Chemother2003，47，： | 1 |
| 5 | Renal function and neurohormonal changes following intravenous infusions of nitroglycerin versus nesiritide in patients with acute decompensated heart failure 显示文摘 | Chow SL O'Barr SA Peng J | 2011 | J Card Fail2011，17，3： | 1 |
| 6 | Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer显示文摘 | Ahrendt SA Chow JT Xu LH | 1999 | J Natl Cancer Inst1999，91，4： | 1 |
| 7 | Alcohol consumption and cigarette smoking increase the frequency of p53 mutations in non-small cell lung cancer显示文摘 | Ahrendt SA Chow JT Yang SC | 2000 | Can Res2000，60，12： | 1 |
| 8 | Cells previously identified as retinal stem ceils are pigmented ciliary epithelial cells显示文摘 | Cicero SA Johnson D Reyntjens S Frase S Connell S Chow L | 2009 | Proc Natl Acad Sci USA2009，106，16： | 1 |
| 9 | Protoporphyrin IX generation from delta-aminolevulinic acid elicits pulmonary artery relaxation and soluble guanylate cyclase activation 显示文摘 | Mingone CJ Gupte SA Chow JL | 2006 | Am J Physiol Lung Cell Mol Physiol2006，291，3： | 1 |
| 10 | A novel gentamicin resistance gene in Enteroccccus显示文摘 | Chow JW Zervos MJ Lerner SA | 1997 | Antimicrob Agents Chemother1997，41，1： | 1 |
| 11 | Hydrolysis of Tetracalcium Phosphate under a Near-constant-composition Condition-effects of pH and Particle Size显示文摘 | Chow LC Markovic M Frukhtbeyn SA | 2005 | Biomaterials2005，26，： | 1 |
| 12 | Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer显示文摘 | Ahrendt SA Chow JT Xu LH | 1999 | Natl Cancer Inst1999，91，4： | 1 |
| 13 | Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer显示文摘 | Ahrendt SA Chow JT Xu LH | 1999 | J Natl Cancer Inst1999，91，4： | 1 |
| 14 | Alcohol and cigarette smoking increase the frequency of p53 mutations in non-small cell lung cancer显示文摘 | Ahrendt SA Chow JT Yang SC | 2000 | Cancer Research2000，60，12： | 1 |
| 15 | Alcohol and cigarette smoking increase the frequency of p53 mutations in non-small cell lung cancer 显示文摘 | Ahrendt SA Chow JT Yang SC | 2000 | Cancer Res2000，60，12： | 1 |
| 16 | Elevated blood pressure in HIV-infected individuals receiving highly active antir etroviral therapy显示文摘 | Chow DC Souza SA Chen R | 2003 | HIV Clin Trials2003，4，6： | 1 |
| 17 | Molecular detection of tumor cells in bronehoalveolar lavage fluid from patients with early stage lung cancer 显示文摘 | Ahrendt SA Chow JT Xu LH | 1999 | J Natl Cancer Inst1999，91，： | 1 |
| 18 | Alcohol consumption and cigarette smoking increase the frequency of p53 mutations in non-small cell lung cancer显示文摘 | Ahrendt SA Chow JT Yang SC | 2000 | Cancer Res2000，60，12： | 1 |
| 19 | Renal function and neurohormonal changes following intravenous infusions of nitroglycerin versus nesiritide in patients with acute decompensated heart failure显示文摘 | Chow SL O'Barr SA Peng J | 2011 | J Card Fail2011，17，3： | 1 |
| 20 | Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer显示文摘 | Ahrendt SA Chow JT Xu LH | 1999 | J Natl Cancer Inst1999，91，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员