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| 1 | 后新公共管理改革——作为一种新趋势的整体政府显示文摘 | Tom Christensen Per Lgreid 张丽娜 袁何俊 | 2006 | 中国行政管理2006,,9: | 248 |
| 2 | 中国高龄老人健康状况和死亡率变动趋势显示文摘文章对'中国老年健康影响因素跟踪调查'近两万名80~105岁高龄老人的数据分析发现,社会经济发展使得2008年高龄老人存活概率和自评日常生活自理能力比1998年有显著改善。医疗条件进步使健康较差高龄老人被'救'存活率提高,使2008年高龄老人客观量测的躯体功能和认知功能比10年前显著下降;这给社会和亿万家庭带来严峻挑战。研究表明,经济社会发展和人类寿命提高带来效益的同时,也会产生一定成本;但它不是以往不少国际文献解释这一现象时所称的'胜利的失败',所以没有必要为此恐慌,而需要全社会积极应对,努力实现人口健康老龄化。 | 曾毅 冯秋石 Therese Hesketh Kaare Christensen James W.Vaupel | 2017 | 人口研究2017,41,4: | 53 |
| 3 | 板蓝根低极性流分的分离及其免疫活性显示文摘目的 :进行板蓝根低极性流分及其亚流分的分离 ,并研究其免疫活性。方法 :用快速低压干柱柱层析从板蓝根中分离出一个低极性流分及其一组亚流分 ;用化学发光法检测其对人多形核细胞化学发光的影响。结果 :板蓝根低极性流分具有双向免疫活性 ,在低浓度时具有激活作用 ,在高浓度时具有抑制作用 ;而亚流分的免疫活性并未因其纯度的提高而相应提高。结论 :板蓝根低极性流分及其亚流分含有抗炎成分。 | 秦箐 贺海平 Soren Brogger Christensen Hasse Bonde Rasmussen Arsalan Kharazmi 陈鸣 | 2001 | 中国临床药学杂志2001,10,1: | 30 |
| 4 | 智能动力混凝土--低强度普通混凝土高性能化的探索与实践(一)显示文摘结合我国原材料和混凝土市场的特点,基于巴斯夫自主知识产权的RheoMATRIX外加剂新技术,提出了以C30为代表的低强度等级普通混凝土的高性能化的概念及解决方案——智能动力混凝土(Smart Dynamic ConcreteTM,SDC)。智能动力混凝土的设计参数:胶凝材料总量低于380kg/m3,初始流动度600~700mm,1h的流动度不小于600mm,T50不超过12s,无泌水、离析现象。大量的试验证明,智能动力混凝土在中国市场上具有广泛的推广应用前景。 | 杨健英 吴慧华 Bruce Christensen Mario Corradi 江靖 李林 冯丘陵 | 2009 | 混凝土2009,,10: | 14 |
| 5 | 一种新的黄芩类黄酮3',5,6',7-四羟基-2',8-二甲氧基黄酮的体外免疫药理作用显示文摘目的 :对新发现的一种黄芩类黄酮 ,3',5 ,6 ',7-四羟基 - 2 ',8-二甲氧基黄酮 ( TDF)的免疫药理作用进行研究。方法 :检测 TDF对人多形核细胞 ( PMN)、单个核细胞 ( MNC)化学发光反应、化学趋向性和 PHA诱导淋巴细胞增殖的影响。结果 :TDF本身不能激活 PMN和 MNC的氧呼吸爆发 ,TDF对 PMN和 MNC无毒性作用 ;当 TDF与 PMN或 MNC预先孵育后 ,明显的抑制 f ML P或 OZ激活 PMN以及 f ML P激活 MNC的氧呼吸爆发 ,抑制的强度与孵育的剂量成正比关系 ;对PMN的抑制能力大于 MNC。 TDF本身对 PMN和 MNC没有明显的化学趋化作用 ,但经与 TDF预先与细胞孵育后的 PMN或 MNC对 ZAS的化学趋向性明显增强 ,对 f ML P的化学趋向性作用不明显 ;TDF浓度在 ( 1.2 5× 10 - 4~ 5× 10 - 4 ) mol/ L 时 ,显著地抑制 PHA诱导的淋巴细胞增殖 ,抑制率达 31%~ 10 0 %。结论 | 贺海平 秦箐 陈明 Arsalan Kharazmi Soren Brogger Christensen | 2000 | 广西医科大学学报2000,17,3: | 14 |
| 6 | miRNA expression profiles in cerebrospinal fluid and blood of patients with Alzheimer’s disease and other types of dementia-an exploratory study显示文摘Background:MicroRNAs(miRNAs)are small non-coding RNA molecules that function as posttranscriptional regulators of gene expression.Measurements of miRNAs in cerebrospinal fluid(CSF)and blood have just started gaining attention as a novel diagnostic tool for various neurological conditions.The purpose of this exploratory investigation was to analyze the expression of miRNAs in CSF and blood of patients with Alzheimer’s disease(AD)and other neurodegenerative disorders in order to identify potential miRNA biomarker candidates able to separate AD from other types of dementia.Methods:CSF was collected by lumbar puncture performed on 10 patients diagnosed with AD and 10 patients diagnosed with either vascular dementia,frontotemporal dementia or dementia with Lewy bodies.Blood samples were taken immediately after.Total RNA was extracted from cell free fractions of CSF and plasma,and a screening for 372 known miRNA sequences was carried out by real time quantitative polymerase chain reactions(miRCURY LNA™Universal RT miRNA PCR,Polyadenylation and cDNA synthesis kit,Exiqon).Results:Fifty-two miRNAs were detected in CSF in at least nine out of ten patients in both groups.Among these,two miRNAs(let-7i-5p and miR-15a-5p)were found significantly up-regulated and one miRNA(miR-29c-3p)was found significantly down-regulated in patients with AD compared to controls.One hundred and sixty-eight miRNAs were frequently detected in the blood,among which miR-590-5p and miR-142-5p were significantly up-regulated and miR-194-5p was significantly down-regulated in AD patients compared to controls.Conclusions:Detection of miRNA expression profiles in blood and in particular CSF of patients diagnosed with different types of dementia is feasible and it seems that several expressional differences between AD and other dementia types do exist when measured in a clinically relevant setup.In this explorative pilot study,the deregulated miRNAs in CSF of AD patients may be associated with relevant target genes related to AD pathology,including APP and BACE1,which suggests that miRNAs are interesting candidates for AD biomarkers in the future. | Sofie Sølvsten Sørensen Ann-Britt Nygaard Thomas Christensen | 2016 | Translational Neurodegeneration2016,5,1: | 14 |
| 7 | 黄芩提取物抗卵巢癌的体外活性研究显示文摘目的 :研究从黄芩中提取获得的化合物黄芩黄酮 A抑制卵巢癌 A2 780细胞生长及对常用抗肿瘤药的体外增效作用。方法 :MTT法测定黄芩黄酮 A的细胞毒作用及与多种抗癌药物作用后对卵巢癌 A2 780细胞的抑制作用 ,集落形成实验观察药物的诱导分化作用 ,PCR- EL ISA试剂盒测定细胞端粒酶活性。结果 :黄芩黄酮 A能抑制 A2 780细胞的增殖 ,其 IC5 0 为 2 0 0 mg/ L,同时黄芩黄酮 A与丝裂霉素 (MMC)、阿霉素 (ADM)、氟尿嘧啶(5 - Fu)、卡铂、羟基喜树碱合用具有相加或协同作用 ,可降低端粒酶活性的表达。结论 :黄芩黄酮 A具有体外抗肿瘤活性 ,对多种化疗药物具有增效作用。 | 秦箐 侯华新 黎丹戎 邱莉 吴华慧 梁永红 Soren Brogger Christensen Hasse Bonde Rasmussen | 2000 | 肿瘤研究与临床2000,12,3: | 13 |
| 8 | 水热条件下绿矾稳定垃圾焚烧飞灰的研究显示文摘研究了饱和温度为200℃的水热条件下绿矾对垃圾焚烧飞灰中重金属的稳定效果,并与常温常压下的稳定效果进行了对比。研究结果表明,高温水热条件有利于Pb特别是Cr(Ⅵ)的稳定,对Cd的稳定无明显影响,同时绿矾的用量大为降低,降低了药剂的成本。 | 胡雨燕 陈德珍 Christensen T H | 2007 | 环境污染与防治2007,29,1: | 11 |
| 9 | Clinical Management of Hepatocellular Carcinoma. Conclusions of the Barcelona-2000 EASL Conference显示文摘 | Jordi Bruix Morris Sherman Josep M Llovet Michel Beaugrand Riccardo Lencioni Andrew K Burroughs Erik Christensen Luigi Pagliaro Massimo Colombo Juan Rodés | 2001 | Journal of Hepatology2001,,3: | 11 |
| 10 | 超越新公共管理:平衡控制与自主的渐增复杂性显示文摘论文主要探讨两个学术问题:在公共组织中,新公共管理和后新公共管理改革的新复杂性和分层的特征是什么?我们应如何分析这种复杂性的发展?政治和行政领导在其发展过程中的角色是什么,其他因素在何种程度上产生了作用?论文在简要地概述从新公共管理改革到后新公共管理改革的变化之后,再以挪威两次改革过程为例经验地说明不断增长的复杂性,从而回答第一个问题。论文联系转型模型和新公共管理及后新公共管理改革中平衡控制与自主的经验以更具理论讨论的形式回答第二个问题。将依据磋商性的、文化的和环境的因素在设计复杂性和平衡政治控制与自主中对潜在层级控制是起限制作用还是起促进作用来讨论这些因素。最后反思新复杂性的某些结果。 | Tom Christensen Per Lgreid 胡辉华 | 2009 | 公共行政评论2009,2,1: | 11 |
| 11 | 绿矾处理垃圾焚烧灰渣过程中重金属的同时稳定化研究显示文摘采用绿矾稳定垃圾焚烧灰渣(包括飞灰及底排渣)中的重金属,将绿矾溶液与灰渣混合然后实施氧化过程.以Pb,Hg,Cd,As和Cr为代表,研究各类重金属同时稳定化的反应条件,着重研究了铬的稳定条件.研究结果表明重金属Pb在各种条件下的稳定效果良好;As和Cd的稳定化效果随绿矾用量的增加而增强,其中Cd还受过程pH值的影响.厌氧阶段的设置、CO2的辅助处理、提高绿矾的用量都有助于Cr的稳定化;同时使用CO2辅助处理也有助于As的稳定化,但CO2只适用于强碱性、高酸中和能力的灰渣.反应温度在常温至90℃变化只影响氧化速度.研究还表明飞灰与底排渣可作为一股废物流同时处理.对Hg,应从研究其物质形态出发来研究它的稳定. | 陈德珍 龚佰勋 姜宗顺 Christensen TH | 2005 | 环境科学学报2005,25,1: | 9 |
| 12 | Can fecal microbiota transplantation cure irritable bowel syndrome?显示文摘AIM To verify the utility of treatment with fecal microbiota transplantation(FMT) in patients with irritable bowel syndrome(IBS).METHODS We searched EMBASE, Cochrane Library and Pub Med in March, 2017. The reviewed literature was based on two systematic searches in each of the databases. The Me SH terms used were IBS and fecal microbiota transplantation and the abbreviations IBS and FMT. Reference lists from the articles were reviewed to identify additional pertinent articles. RESULTS A total of six conference abstracts, one case report, one letter to the editor, and one clinical review were included. In the final analysis, treatment of 48 patients was evaluated. Treatment revealed an improvement in 58% of cases. The varying structure of the nine included studies must be taken into consideration.CONCLUSION Data on FMT and IBS are too limited to draw sufficientconclusions. Standardized double blinded randomized clinical trials need to be carried out to evaluate the effect of FMT on IBS. | Sofie Ingdam Halkjar Anders Watt Boolsen Stig Günther Alice Hojer Christensen Andreas Munk Petersen | 2017 | World Journal of Gastroenterology2017,23,22: | 8 |
| 13 | 智能动力混凝土--低强度等级普通混凝土高性能化的探索与实践(二)显示文摘研究了智能动力混凝土各组成材料及外加剂对混凝土新拌性能的影响。结果表明,BASF新型黏度改性剂RheoMATRIX降低了混凝土对用水量与原材料质量波动的敏感性,但其掺量不宜过大,否则会引起混凝土流动性下降,但对混凝土强度无负面影响。此外,骨料的颗粒级配对于混凝土流动性能影响明显,在实际应用中需通过试验确定最佳骨料级配。大量的现场试验证明,Glenium 6xxx SDC能在中国多种原材料条件下,配制出性能优异的智能动力混凝土。 | 杨健英 Bruce Christensen 李林 冯丘陵 黄超 吴建越 吴慧华 赵昕南 李桂青 黄键 | 2009 | 混凝土2009,,12: | 7 |
| 14 | 碱性系统中铁对铬的还原作用及其对飞灰中铬的浸出控制显示文摘为了控制焚烧飞灰中铬的浸出,将FeSO4加入焚烧飞灰水系统中和Cr(Ⅵ)的碱性水溶液中,试验二价铁(Fe(Ⅱ))对Cr(Ⅵ)的还原效果,并检验了Cr(Ⅵ)的还原产物的稳定性.热力学分析表明,碱性系统中Fe(Ⅱ)对Cr(Ⅵ)的还原受到Fe(Ⅱ)与O2反应的强烈竞争.实验结果也证实了暴露于空气的飞灰水系统中的Fe(Ⅱ)对铬没有明显的控制效果,但在碱性溶液相中过量的Fe(Ⅱ)却能快速有效地还原Cr(Ⅵ),且还原产物十分稳定.此外,焚烧飞灰中铬的溶出受到Pb、Ba、Ca等元素的干扰,不利于Cr(Ⅵ)的还原稳定.为了有效地稳定Cr(Ⅵ),Fe(Ⅱ)稳定飞灰的过程可分两步进行.试验结果还表明,在碱性系统中铁的氧化物氢氧化物对Cr(Ⅵ)的吸附和沉淀效果十分有限. | 陈德珍 袁园 Thomas H Christensen | 2005 | 环境科学学报2005,25,9: | 6 |
| 15 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019,4,1: | 6 |
| 16 | 直接甲醇燃料电池管状阴极的制备与性能显示文摘以管状金属钛网为支撑体,采用浸涂工艺在其外表面依次制备了气体扩散层、Pt/C催化层和Nafion膜,制得管状阴极,并分析了影响电池性能的因素.研究结果表明,采用浆液浸涂工艺制备的阴极气体扩散层与催化层,均具有有利于气体传质和电化学反应的多孔结构.随着阴极催化剂载量的增加,单电池的性能也逐渐提高.当Pt载量为4.3 mg/cm2时,常温下以空气作为氧化剂,电池功率密度峰值约为12.3 mW/cm2,而同样的电池,在60℃下以氧气作为氧化剂,则可以达到40.0 mW/cm2,这表明温度和氧化剂种类与催化剂载量一样,是影响电池性能的重要因素.电池经约100 h工作时间后进行的等电压放电试验结果表明,该管状Ti基阴极的电化学稳定性优良. | 倪红军 李飞 汤东 汪兴兴 林文峰 Christensen Paul A | 2009 | 江苏大学学报(自然科学版)2009,30,2: | 5 |
| 17 | Gorenstein dimensions of unbounded complexes and change of base (with an appendix by Driss Bennis)显示文摘For a commutative ring R and a faithfully flat R-algebra S we prove,under mild extra assumptions,that an R-module M is Gorenstein flat if and only if the left S-module S?_R M is Gorenstein flat,and that an R-module N is Gorenstein injective if and only if it is cotorsion and the left S-module Hom R(S,N)is Gorenstein injective.We apply these results to the study of Gorenstein homological dimensions of unbounded complexes.In particular,we prove two theorems on stability of these dimensions under faithfully flat (co-)base change. | CHRISTENSEN Lars Winthe KOKSAL Fatih LIANG Li | 2017 | Science China Mathematics2017,60,3: | 5 |
| 18 | 智能动力混凝土─低标号自密实混凝土的探索与实践显示文摘本文结合我国原材料和混凝土市场的特点,基于巴斯夫自主知识产权的RheoMATRIX外加剂新技术,提出了以C30为代表的低标号自密实混凝土的新概念及解决方案-智能动力混凝土(Smart Dynamic Concrete^TM,SDC)。智能动力混凝土的设计参数:胶凝材料总量低于380kg/m^3,初始流动度600-670mm,1hr的流动度不小于600mm,T50不超过12s,无泌水、离析现象。大量的试验证明,智能动力混凝土在中国市场上具有广泛的推广应用前景。 | 杨健英 吴慧华 Bruce Christensen 江靖 李林 冯丘陵 | 2009 | 福建建筑2009,,12: | 5 |
| 19 | 23种挥发性有机化合物在3种吸附剂上漏出容量的测定评价显示文摘采用吸附热解吸 -气相色谱 -质谱法对23种挥发性有机化合物在Chromosorb106、TenaxTA、TenaxTG等3种吸附剂上漏出容量进行了测定。根据实验结果确定了不同的化合物应选择不同的吸附剂及相应的采样体积。结果表明,Chromosorb106可较好地吸附低沸点的挥发性有机化合物,TenaxTA、TenaxTG均可用于沸点较高的挥发性有机化合物吸附,这对测定大气中的有机化合物含量的采样有一定的参考价值。 | 吴风武 Torben CHRISTENSEN Niels HAUNSO | 2000 | 分析测试学报2000,19,5: | 5 |
| 20 | Viral evasion of DNA-stimulated innate immune responses显示文摘导出病毒的 nucleic 酸的细胞的察觉到为对病毒感染的早防卫是必要的。在最近的年里,包括周期的 GMP 安培 synthase (cGAS ) 和 gamma-interferon-inducible 蛋白质(IFI16 ) ,察觉到蛋白质的 DNA 的发现导致了房间怎么对带 DNA 染色体的到来的病原体唤起强壮的天生的有免疫力的回答的理解。发信号由 DNA 传感器刺激了取决于适配器蛋白质圈套(干扰素基因的激发器) ,到启用抗病毒的蛋白质的表示,包括类型我干扰素。便于有效感染,病毒发展了大量避免策略,指向的主人 DNA 传感器,适配器蛋白质和抄写因素。在这评论, STING 小径的导致病毒的激活上的当前的文学被介绍,我们讨论在这条抗病毒的小径指向不同的步的最近识别的病毒的避免机制。 | Maria H Christensen Sфren R Paludan | 2017 | Cellular & Molecular Immunology2017,14,1: | 4 |