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| 1 | Risk of cardiovascular,cardiac and arrhythmic complications in patients with non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)has emerged as a public health problem of epidemic proportions worldwide.Accumulating clinical and epidemiological evidence indicates that NAFLD is not only associated with liver-related morbidity and mortality but also with an increased risk of coronary heart disease(CHD),abnormalities of cardiac function and structure(e.g.,left ventricular dysfunction and hypertrophy,and heart failure),valvular heart disease(e.g.,aortic valve sclerosis)and arrhythmias(e.g.,atrial fibrillation).Experimental evidence suggests that NAFLD itself,especially in its more severe forms,exacerbates systemic/hepatic insulin resistance,causes atherogenic dyslipidemia,and releases a variety of pro-inflammatory,pro-coagulant and pro-fibrogenic mediators that may play important roles in the pathophysiology of cardiac and arrhythmic complications.Collectively,these findings suggest that patients with NAFLD may benefit from more intensive surveillance and early treatment interventions to decrease the risk for CHD and other cardiac/arrhythmic complications.The purpose of this clinical review is to summarize the rapidly expanding body of evidence that supports a strong association between NAFLD and cardiovascular,cardiac and arrhythmic complications,to briefly examine the putative biological mechanisms underlying this association,and to discuss some of the current treatment options that may influence both NAFLD and its related cardiac and arrhythmic complications. | Stefano Ballestri Amedeo Lonardo Stefano Bonapace Christopher D Byrne Paola Loria Giovanni Targher | 2014 | World Journal of Gastroenterology2014，20，7： | 55 |
| 2 | Obstructive sleep apnea syndrome and fatty liver: Association or causal link?显示文摘Obstructive sleep apnea (OSA) is a complex disorder that consists of upper airway obstruction, chronic intermittent hypoxia and sleep fragmentation. OSA is well known to be associated with hypoxia, insulin resistance and glucose intolerance, and these factors can occur in the presence or absence of obesity and metabolic syndrome. Although it is well established that insulin resistance, glucose intolerance and obesity occur frequently with non-alcoholic fatty liver disease (NAFLD), it is now becoming apparent that hypoxia might also be important in the development of NAFLD, and it is recognized that there is increased risk of NAFLD with OSA. This review discusses the association between OSA, NAFLD and cardiovascular disease, and describes the potential role of hypoxia in the development of NAFLD with OSA. | Mohamed H Ahmed Christopher D Byrne | 2010 | World Journal of Gastroenterology2010，16，34： | 7 |
| 3 | 成人非酒精性脂肪性肝病的诊断与监测显示文摘在一项常规体检中,一名52岁,经常久坐不动的电脑程序员发现其血清丙氨酸氨基转移酶(ALT)浓度为68 IU/L(正常0~40 IU/L),甘油三酯浓度为1.9 mmol/L。空腹血糖5.8 mmol/L,其他肝、肾、血脂基础检查正常。他没有什么重大疾病史,没有常规服用的药物,不吸烟,每周饮酒量少于7个单位。临床检查也没有什么异常发现。他的体质指数为29 kg/m^2,腰围102 cm,血压134/88 mmHg。几个月后复查的血清ALT仍然升高,为62 IU/L。 | Christopher D Byrne Janisha Palel Eleonora Scorletti Giovanni Targher 张亚男(译) 范竹萍(审校) | 2020 | 英国医学杂志中文版2020，23，1： | 0 |
| 4 | Metabolic Dysfunction-associated Fatty Liver Disease is Associated with Greater Impairment of Lung Function than Nonalcoholic Fatty Liver Disease显示文摘Background and Aims:We compared lung function parameters in nonalcoholic fatty liver disease(NAFLD)and metabolic dysfunction-associated fatty liver disease(MAFLD),and examined the association between lung function parameters and fibrosis severity in MAFLD.Methods:In this cross-sectional study,we randomly recruited 2,543 middle-aged individuals from 25 communities across four cities in China during 2016 and 2020.All participants received a health check-up including measurement of anthropometric parameters,biochemical variables,liver ultrasonography,and spirometry.The severity of liver disease was assessed by the fibrosis(FIB)-4 score.Results:The prevalence of MAFLD was 20.4%(n=519)and that of NAFLD was 18.4%(n=469).After adjusting for age,sex,adiposity measures,smoking status,and significant alco-hol intake,subjects with MAFLD had a significantly lower predicted forced vital capacity(FVC,88.27±17.60%vs.90.82±16.85%,p<0.05)and lower 1 s forced expiratory volume(FEV1,79.89±17.34 vs.83.02±16.66%,p<0.05)than those with NAFLD.MAFLD with an increased FIB-4 score was significantly associated with decreased lung function.For each 1-point increase in FIB-4,FVC was diminished by 0.507(95%CI:-0.840,-0.173,p=0.003),and FEV1 was diminished by 0.439(95%CI:-0.739,-0.140,p=0.004).The results remained unchanged when the statistical analyses was performed separately for men and women.Conclusions:MAFLD was significantly asso-ciated with a greater impairment of lung function param-eters than NAFLD. | Lei Miao Li Yang Li-Sha Guo Qiang-Qiang Shi Teng-Fei Zhou Yang Chen Huai Zhang Hui Cai Zhi-Wei Xu Shuan-Ying Yang Hai Lin Zhe Cheng Ming-Yang Zhu Xu Nan Shuai Huang Ya-Wen Zheng Giovanni Targher Christopher D Byrne Yu-Ping Li Ming-Hua Zheng Cheng-Shui Chen | 2022 | Journal of Clinical and Translational Hepatology2022，10，2： | 0 |
| 5 | 对中-高度心血管危险人群,他汀类药物治疗使新发糖尿病轻度增多,但收益可能超过任何副作用显示文摘他汀类药物是使用范围最广的一类药物,仅在2008年,英国就大约开出了5千万张他汀类药物的处方。他汀类药物能显著减少中-高危病人的心血管事件,其在一级和二级预防中的有效性和安全性已经确立。常见报道的不良反应包括肌痛和肝酶升高,但总体上他汀类药物治疗中不良反应的发生率甚低,其耐受性良好。不过, | Lokpal Bhatia Christopher D Byrne 范维琥(译) | 2010 | 英国医学杂志中文版2010，13，5： | 0 |
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