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| 1 | Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats显示文摘 | Ali Keshavarzian Ashkan Farhadi Christopher B. Forsyth Jayanthi Rangan Shriram Jakate Maliha Shaikh Ali Banan Jeremy Z. Fields | 2009 | Journal of Hepatology2009，，3： | 3 |
| 2 | Ethanol‐Induced Mast Cell‐Mediated Inflammation Leads to Increased Susceptibility of Intestinal Tumorigenesis in the APCΔ468 Min Mouse Model of Colon Cancer显示文摘 | Andre L. Wimberly Christopher B. Forsyth Mohammad W. Khan Alan Pemberton Khashayarsha Khazaie Ali Keshavarzian | 2013 | Alcohol Clin Exp Res2013，，： | 1 |
| 3 | Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats显示文摘 | Ali Keshavarzian Ashkan Farhadi Christopher B. Forsyth Jayanthi Rangan Shriram Jakate Maliha Shaikh Ali Banan Jeremy Z. Fields | 2009 | Journal of Hepatology2009，，3： | 1 |
| 4 | Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis显示文摘 | Christopher B. Forsyth Ashkan Farhadi Shriram M. Jakate Yueming Tang Maliha Shaikh Ali Keshavarzian | 2009 | Alcohol2009，，2： | 1 |
| 5 | Inter-hospital transfers and door-to-balloon times for STEMI: a single centre cohort study显示文摘Background Key performance indices such as door-to-balloon times have long been recognized as quality metrics in reducing time to care for patients with acute coronary syndromes(ACS). In the situation where patients do not present to a facility capable of 24/7 percutaneous coronary interventions(PCI) delays in time to therapy can exceed the recommendation of 90 min or less. This study aimed to evaluate the impact of transfers on performance indices for patients diagnosed with ST-segment elevation myocardial infarction(STEMI). Methods Over a seven month collection period, all patients presenting with symptoms suggestive of ACS and admitted for PCI were studied. Patients were divided into dichotomous groups of direct presentations or transfers from a secondary non-PCI capable hospital with key times recorded, including symptom-onset, first hospital and PCI-capable hospital arrival and balloon inflation times to evaluate time of treatment for STEMI patients. Results Of the 87 patients diagnosed with STEMI, transferred patients experienced statistically significant delays in symptom-onset to the PCI-capable hospital(PCI-H) arrival(215 vs. 95 min, P < 0.001), symptom-onset to balloon inflation(225 vs. 160 min, P = 0.009) and first hospital arrival to balloon inflation times(106 vs. 56 min, P < 0.001). Only 28%(n = 9) of transferred patients underwent balloon inflation within 90 min from first hospital arrival, while 60%(n = 19) did within 120 min, although all received balloon inflation within 90 min from arrival at the PCI-H. After controlling for confounding factors of socio-economic status, presentation date/time and diagnostic category, transferred patients experienced an average 162% longer delays from symptom-onset to PCI-H door arrival, and 98% longer delays in symptom-onset to balloon inflation;compared to patients who present directly to the PCI-H. No statistically significant differences were noted between transferred and direct patients when measured from PCI-H door-to-balloon times. Conclusions This study shows that transferred patients experience a greater overall system delay, compared to patients who present directly for PCI, significantly increasing their time to treatment and therefore infarct times. Despite the majority of transfers experiencing pre-hospital activation, their treatment hospital arrival to balloon times are no less than direct presenters after controlling for confounding factors, further compounding the overall delay to therapy. | RenéForsyth Zhong-Hua SUN Christopher Reid Rachael Moorin | 2020 | Journal of Geriatric Cardiology2020，17，6： | 1 |
| 6 | A Prospective Randomized Controlled Trial of Multimodal Perioperative Management Protocol in Patients Undergoing Elective Colorectal Resection for Cancer显示文摘 | Chun Kheng Khoo Christopher J. Vickery Nicola Forsyth Nina S. Vinall Ian A. Eyre-Brook | 2007 | Annals of Surgery2007，，6： | 1 |
| 7 | The Versatility and Diagnostic Potential of VOC Profiling for Noninfectious Diseases显示文摘variety of volatile organic compounds(VOCs)are produced and emitted by the human body every day.The identity and concentration of these VOCs reflect an individual’s metabolic condition.Information regarding the production and origin of VOCs,however,has yet to be congruent among the scientific community.This review article focuses on the recent investigations of the source and detection of biological VOCs as a potential for noninvasive discrimination between healthy and diseased individuals.Analyzing the changes in the components of VOC profiles could provide information regarding the molecular mechanisms behind disease as well as presenting new approaches for personalized screening and diagnosis.VOC research has prioritized the study of cancer,resulting in many research articles and reviews being written on the topic.This review summarizes the information gained about VOC cancer studies over the past 10 years and looks at how this knowledge correlates with and can be expanded to new and upcoming fields of VOC research,including neurodegenerative and other noninfectious diseases.Recent advances in analytical techniques have allowed for the analysis of VOCs measured in breath,urine,blood,feces,and skin.New diagnostic approaches founded on sensor-based techniques allow for cheaper and quicker results,and we compare their diagnostic dependability with gas chromatography-and mass spectrometry-based techniques.The future of VOC analysis as a clinical practice and the challenges associated with this transition are also discussed and future research priorities are summarized. | Micah Oxner Allyson Trang Jhalak Mehta Christopher Forsyth Barbara Swanson Ali Keshavarzian Abhinav Bhushan | 2023 | Biomedical Engineering Frontiers2023，4，1： | 0 |
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