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1篇 您的检索式：作者名="Christopher M.Ferguson"

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		题名	作者	年代	出处	被引量
	1	Augmented efficacy of exogenous extracellular vesicles targeted to injured kidneys显示文摘Dear Editor,Extracellular vesicles(EVs)derived from mesenchymal stem/stromal cells(MSCs)contain genetic and protein material that stimulate tissue repair and ameliorate injury in recipient cells.Advantages of particulate MSC-EVs over MSCs in treating kidney disease include better penetration of injured glomerular filtration barrier to access podocytes or tubular cells.However,systemic EV delivery yields low kidney retention efficiency,limiting their regenerative benefits.1 Previously,we coated adipose tissue-derived(AD)-MSC with antibodies against kidney injury molecule(KIM)‐1(ab-KIM1),a protein upregulated in damaged kidneys.2 Conjugating ab-KIM1 did not impair MSC function but increased their retention and reparative potency in murine renal artery stenosis(RAS).2 We hypothesized that ab-KIM1 conjugation would similarly enhance retention of exogenously delivered EVs in ischemic kidneys and confer superior therapeutic benefits.	Xiao-Jun Chen Kai Jiang Christopher M.Ferguson Hui Tang Xiangyang Zhu Amir Lerman Lilach O.Lerman	2020	Signal Transduction and Targeted Therapy2020，5，1：	0

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