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73篇 您的检索式：作者名="Christova"

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	题名	作者	年代	出处	被引量
1	Novel MLH1 frameshift mutation in an extended hereditary nonpolyposis colorectal cancer family显示文摘AIM: To present novel frameshift mutation c.31delC [p.L11X] in the MLH1 gene identified in an extended Bulgarian hereditary non-polyposis colorectal cancer (HNPCC) family and to analyze the molecular and clinical findings within the pedigree concerning the proposal of adequate individual prophylactic strategy for all mutation carriers. METHODS: The pedigree of the family consists of 42 members in four generations. Search for mutations in the MLH1 and hMSH2 genes was performed in the pro-band. After PCR amplification of all exons including flanking intronic regions, amplicons were directly sequenced. RESULTS: The mutation was found in nine from the thirteen pedigree members who signed informed consent to participate in the study. In three adenocarcinomas, microsatellite instability and lack of the MLH1 protein expression were detected. The only one tubulovillous adenoma analyzed was microsatellite stable and the MLH1 protein showed an intact staining. CONCLUSION: The newly described mutation c.31delC is HNPCC causative. Besides the typical clinical features of the syndrome, we found a specific pathologic manifestation such as moderate to high differentiated adenocarcinomas of the colon. One of the mutation carriers developed a benign giant cell soft tissue tumor. The primary tumor localizations were frequently extracolonic and detailed yearly gastrointestinal and gynecological examinations have been proposed to the mutation carriers. We emphasize the importance of including the HNPCC genetic counseling and testing as well in the following surveillance of all patients at risk in the services covered by the health insurance in Bulgaria.	Tanya Kirilova Kadiyska Radka Petrova Kaneva Dimitar Georgiev Nedin Alexandrina Borisova Alexandrova Antonina Todorova Gegova Stoyan Ganchev Lalchev Tatyana Christova Vanio Ivanov Mitev Juergen Horst Nadja Bogdanova Ivo Marinov Kremensky	2006	World Journal of Gastroenterology2006，12，48：	2
2	Kinetics of oxygen delignification of hardwood kraft pulp 显示文摘	VALCHEV I VALCHEVA E CHRISTOVA E	1999	Cellulose Chem Technol1999，33，：	1
3	Assessment of genetic variability induced by chemical mutagenesis in elite maize germplasm via SSR markers显示文摘	Kostova A Todorovska E Christova N Hristov K Atanassov A	2006	Crop Improvement2006，16，12：	1
4	Rhamnolipid biosurfactants produced by Renibacterium salmoninarum 27BN during growth on n-hexadecane显示文摘	CHRISTOVA N TULEVA B LALCHEV Z	2004	Z Naturforsch C2004，59，12：	1
5	Enhanced hydrocarbon biodegradation by a newly isolated Bacillus subtilis strain显示文摘	CHRISTOVA N TULEVA B NIKOLOVA-DAMYANOVA B	2004	Z Naturforsch C2004，59，34：	1
6	Antibacterial activity of essential oils from Brazilian propolis显示文摘	V Bankova R Christova S Popova	1999	Fitoterapia1999，70，2：	1
7	Hydrophobization of glass surface by adsorption of poly (dimethylsiloxane)显示文摘	Marinova K G Christova D Tcholakova S	2005	Langmuir2005，21，11：	1
8	Foamed crosslinked LDPE/PP blends made by hot mold injection molding显示文摘	Touleshkov N Christova D	2002	Macromolecular Symposia2002，181，1：	1
9	Exploring Small City Maps 显示文摘	Christova P Scoppa M Peponis J	2012	Experimental Brain Research2012，223，2：	1
10	Cognitive Mechanisms Underlying Instructed Choice Exploration of Small City Maps 显示文摘	Sakellaridi S Christova P Christopoulos V N	2015	Frontiers in Neuroscience2015，9，：	1
11	Effect of hypoxia on the binding andsubcellular distribution of iron regulatory proteins显示文摘	Christova T Templeton DM	2007	Mol CellBiochem2007，301，12：	1
12	Layer-by-Layer Growth of Binary Colloldal Crystals显示文摘	Velikov K P Christova C G Dullens R P	2002	Science2002，296，：	1
13	Inhibition of tankyrases induces Axin stabilization and blocks Wnt signalling in breast cancer cells显示文摘	Bao R Christova T Song S		0，，11：	1
14	Copper-Cobalt oxide spinel supported on high-temperature aluminosilicate carriera as catalyst for CO-O2 和 CO-NO reactions 显示文摘	Stoyanova D Christova M Dimitrova P	1998	Appl Catal B: Environment1998，17，3：	1
15	Mechanical flutter stimulation induces a lasting response inthe sensorimotor cortex as revealed with BOLD fMRI显示文摘	Christova M Golaszewski S Ischebeck A	2013	Hum Brain Mapp2013，34，11：	1
16	A cold-inducible multidomain eystatin of winter wheat inhibits growth of the snow mold fungus, Microdochium nivale显示文摘	Christova P D Christov N K Imai R	2006	Planta2006，223，：	1
17	Production and structural elucidation of trehalose tetraesters (biosurfactants) from a novel alkanothrophic Rhodococcus wratislaviensis strain 显示文摘	Tuleva B Christova N Cohen R	2008	J Appl Microbiol2008，104，：	1
18	Naphthalene degradation and biosurfactant activity by Bacillus cereus 28 BN 显示文摘	Tuleva B Christova N Jordanov B	2005	Z Natufforsch2005，60，78：	1
19	Flow behaviour of gas-containing LDPE/i -PP melts显示文摘	Djoumaliisky S Christova D Petrov I	2002	Macromolecular Symposia2002，181，：	1
20	Copper-Cobalt oxide spinel supported on high-temperature aluminosilicate carriera as catalyst for CO-O2 & CO-NO reactions 显示文摘	Stoyanova D Christova M Dimitrova P	1998	Appl Catal B: Environment1998，17，3：	1

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