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| 1 | Efficacy and safety evaluation of icotinib in patients with advanced non-small cell lung cancer显示文摘Objective: To evaluate the efficacy and safety of icotinib hydrochloride in patients with advanced non-small cell lung cancer (NSCLC). Methods: A total of 89 patients with stage ⅢB or IV NSCLC received icotinib at a dose of 125 mg administered 3 times a day. Icotinib treatment was continued until disease progression or development of unacceptable toxicity. Results: A total of 89 patients were assessable. In patients treated with icotinib, the overall response rate (RR) was 36.0% (32/89), and the disease control rate (DCR) was 69.7% (62/89). RR and DCR were significantly improved in patients with adenocarcinoma versus non-adenocarcinoma (P<0.05). The symptom improvement rate was 57.3% (51/89), and the main symptoms improved were cough, pain, chest distress, dyspnea, and Eastern Cooperative Oncology Group performance status. The main toxic effects were rash [30/89 (33.7%)] and diarrhea [15/89 (16.9%)]. The level of toxicity was typically low. Conclusions: The use of icotinib hydrochloride in the treatment of advanced NSCLC is efficacious and safe, and its toxic effects are tolerable. | Aiqin Gu Chunlei Shi Liwen Xiong Tianqing Chu Jun Pei Baohui Han | 2013 | Chinese Journal of Cancer Research2013，25，1： | 22 |
| 2 | The Impacts of Maternal Gestational Diabetes Mellitus (GDM) on Fetal Hearts显示文摘Objective To evaluate the fetal cardiac function in gestational diabetes mellitus (GDM) pregnancies under different maternal glycemic controls.Methods Forty four GDM mothers received 78 fetal echocardiographic evaluations at three gestational periods (<28,28-34 and ≥34 weeks) and were divided into poorly-(DM1) and well-(DM2) controlled groups according to their glycemic control at examination.Seventy uncomplicated mothers were selected as controls.Parameters of fetal cardiac anatomy and function were measured and analyzed.Results GDM fetuses' cardiac ventricular walls were thicker than controls',and the differences between DM1 and DM2 were not significant except for end-diastolic left ventricular walls.In both GDM groups,the aortic flow velocities increased earlier than pulmonary artery and DM1 fetuses changed earlier than DM2 ones.GDM fetuses' left atrial shortening fraction was smaller than the controls' in the period of ≥34 weeks and negatively correlated with thicknesses of left ventricular walls and interventricular septum in DM1 fetuses (r=-0.438 and -0.506).The right ventricular diastolic function in DM1 and DM2 fetuses decreased after the period of 28-34 weeks and in the period of ≥34 weeks respectively.Tei index of both left and right ventricles increased in DM1 group after the period of<28 weeks and in DM2 group only in the period of ≥34 weeks,with no significant differences between DM1 and DM2 groups in this period.Conclusion Fetuses of GDM mothers showed cardiac function impairments.Good maternal glycemic control may delay the impairments,but cannot reduce the degree.Some cardiac changes in GDM fetuses were similar to those in pregestational diabetic pregnancies except for several parameters and their changing time. | CHU Chen GUI Yong Hao PEN Yun Yun SHI Li Ye | 2012 | Biomedical and Environmental Sciences2012，25，1： | 20 |
| 3 | Effects of Slope Aspects on Soil Bacterial and Arbuscular Fungal Communities in a Boreal Forest in China显示文摘在 forested 环境的土壤 biogeochemical 性质和植物社区上的斜坡方面的效果广泛地被学习了;然而,倾斜对的方面影响大部分玷污微生物引起的社区遗体 unexamined,尽管有在生态系统工作的土壤生物区系的中央角色。在这研究,土壤细菌和 arbuscular mycorrhizal 真菌(AMF ) 的社区在更大的 Khingan 山的一个北方的森林里为斜坡方面(面对南方的方面,面对北方的方面和扁平的区域) 的三种类型用标注 pyrosequencing 被调查,中国。细菌并且 AMF 社区作文与斜坡方面不同。细菌的差异在面对北方的方面上是最低的,并且 AMF 差异在扁平的区域上是最低的。方面也在土壤 pH 和可得到的磷(P) 和灌木状的生物资源上有重要影响。土壤 pH 和 understory 灌木生物资源显著地与细菌的社区被相关,并且玷污可得到的 P 和灌木生物资源与 AMF 社区的显示出的重要关联。我们的结果建议了那个斜坡细菌的影响的方面和 AMF 社区,在植物社区和土壤化学药品性质由导致方面的变化调停了(例如, pH 和可得到的 P ) ,它在森林斜坡方面的效果上改进了知识在上未葬、地下社区。 | CHU Haiyan XIANG Xingjia YANG Jian Jonathan M. ADAMS ZHANG Kaoping LI Yuntao SHI Yu | 2016 | Pedosphere2016，26，2： | 15 |
| 4 | 20C, a bibenzyl compound isolated from Gastrodia elata, protects PC12 cells against rotenone-induced apoptosis via activation of the Nrf2/ARE/HO-1 signaling pathway显示文摘瞄准:我们 bibenzyl 混合物从 Gastrodia elata 孤立的初步的学习表演, 2-[4-hydroxy-3-(4-hydroxybenzyl ) 本甲基]-4-(4-hydroxybenzyl)phenol (指明的 20C ) ,保护 PC12 房间免于 H 2 O 2-induced 损害。在这研究,我们调查了 20C 是否在 Parkinsons disease.Methods 的一个房间模型施加了 neuroprotective 行动:Parkinsons 疾病的一个房间模型被暴露在 PC12 房间建立到毒鱼藤素(4 μ mol/L ) 为 48 h。房间生存能力和 apoptosis 被估计,并且细胞内部的 ROS 水平和 mitochondrial 膜潜力(MMP ) 被检测。apoptosis 相关的蛋白质 Bax, Bcl-2,细胞色素 c,劈开的 caspase-3,和氧化压力相关的蛋白质 Nrf2, HO-1 和 NQO1 的表示用西方的弄污被检验。HO-1 和 NQO1 的 mRNA 层次与 RT-PCR 被决定。Nrf2 的原子 translocation 与 immunofluorescence staining.Results 被观察:有毒鱼藤素的处理显著地增加了 apoptotic 房间的数字,由 Bax/Bcl-2 比率,细胞色素 c 版本和 caspase-3 激活的显著增加伴随了。毒鱼藤素也增加了 ROS 累积,减少了 MMP,并且增加了 Nrf2 的原子 translocation 以及在 PC12 房间的 Nrf2 下游的目标基因 HO-1 和 NQO1 的 mRNA 和蛋白质层次。有 20C 的合作处理(0.01-1 μ mol/L ) 在 PC12 房间的 dose-dependently 稀释的导致毒鱼藤素的 apoptosis 和氧化应力。由 siRNA 击倒的 Nrf2 部分在对待毒鱼藤素的 PC12 cells.Conclusion 颠倒了 20C 的保护的效果:bibenzyl 混合物 20C 保护 PC12 房间免受导致毒鱼藤素的 apoptosis 的伤害,至少部分地,经由发信号的 Nrf2/ARE/HO-1 的激活小径。 | Ju-yang HUANG Yu-he YUAN Jia-qing YAN Ya-nan WANG Shi-feng CHU Cheng-gen ZHU Qing-lan GUO Jian-gong SHI Nai-hong CHEN | 2016 | Acta Pharmacologica Sinica2016，37，6： | 13 |
| 5 | Genetic Analysis and Primary Mapping of pms4, a Photoperiod-Sensitive Genic Male Sterility Gene in Rice (Oryza sativa)显示文摘To understand the genetic characteristics of a new photoperiod-sensitive genic male sterile line Mian 9S, some reciprocal crosses were made between Mian 9S and six indica rice materials, Yangdao 6, Luhui 602, Shuihui 527, Mianhui 725, Fuhui 838 and Yixiang 1B. Genetic analysis results suggested that the photoperiod-sensitive genic male sterility (PGMS) of Mian 9S was controlled by a single recessive nuclear gene. Thus, the F2 population derived from the cross of Yangdao 6/Mian 9S was used to map the PGMS gene in Mian 9S. By using SSR markers, the PGMS gene of Mian 9S was mapped on one side of the markers, RM6659 and RM1305, on rice chromosome 4, with the genetic distances of 3.0 cM and 3.5 cM, respectively. The gene was a novel PGMS gene and designated tentatively as pms4. In addition, the application of the pms4 gene was discussed. | HUANG Ting-you WANG Zhi HU Yun-gao SHI Shou-pei PENG Tao CHU Xu-dong SHI Jun XIANG Zu-fen LIU Ding-you | 2008 | Rice science2008，15，2： | 13 |
| 6 | Effects of impregnation sequence on the microstructure and performances of Cu-Co based catalysts for the synthesis of higher alcohols显示文摘支持硅石的 CuCo 催化剂被受精方法为更高的白酒合成与不同受精顺序作好准备。这些催化剂被 H 2-TPR, XRD, N 2 吸附, XPS 技术和公司描绘选择加氢反应测量。催化剂的结构和表演上的受精顺序的效果被调查,并且到更高的白酒的选择上有重要影响。为共同使妊娠的样品在铜和钴之间有强壮的 synergistic 效果。合作受精准备的 CuCo/SiO 2 催化剂显示了全部的白酒,和一种更高的选择的更好的收益总计到达了 51.5% 的白酒。 | Siyu Deng Wei Chu Huiyuan Xu Limin Shi Lihong Huang | 2008 | Journal of Natural Gas Chemistry2008，17，4： | 10 |
| 7 | A Five-year Surveillance of Carbapenemase-producing Klebsiella pneumoniae in a Pediatric Hospital in China Reveals Increased Predominance of NDM-1显示文摘Objective To characterize carbapenem(CPM)-non-susceptible Klebsiel a pneumoniae(K. pneumoniae) and carbape-nemase produced by these strains isolated from Beijing Children's Hospital based on a five-year surveillance. Methods The Minimal Inhibition Concentration values for 15 antibiotics were assessed using the Phonix100 compact system. PCR amplification and DNA sequencing were used to detect genes encoding carbapenemases. WHONET 5.6 was finally used for resistance analysis. Results In total, 179 strains of CPM-non-susceptible K. pneumoniae were isolated from January, 2010 to December, 2014. The rates of non-susceptible to imipenem and meropenem were 95.0% and 95.6%, respectively. In the 179 strains, 95(53.1%) strains carried the blaIMP gene, and IMP-4 and IMP-8 were detected in 92(96.8%) and 3(3.2%) IMP-producing isolates, respectively. 65(36.3%) strains carried the blaNDM-1 gene. 6(3.4%) strains carried the blaKPC gene, and KPC-2 were detected in 6 KPC-producing isolates. In addition, New Delhi-Metallo-1(NDM-1) producing isolates increased from 7.1% to 63.0% in five years and IMP-4 producing isolates decreased from 75.0% to 28.3%. Conclusion High frequencies of multiple resistances to antibiotics were observed in the CPM-non-susceptible K. pneumoniae strains isolated from Beijing Children's Hospital. The production of IMP-4 and NDM-1 metallo-β-lactamases appears to be an important mechanism for CPM-nonsusceptible in K. pneumoniae. | DONG Fang LU Jie WANG Yan SHI Jin ZHEN Jing Hui CHU Ping ZHEN Yang HAN Shu Jing GUO Yong Li SONG Wen Qi | 2017 | Biomedical and Environmental Sciences2017，30，8： | 10 |
| 8 | A novel cytotoxic neophysalin from Physalis alkekengi var.francheti显示文摘新 neophysalin,把 5 称为 α -hydroxy-25,27-dihydro-4,7-didehydro-7-deoxyneophysalin A (1 ) ,与三另外的已知的 neophysalins 一起(2 – 4 ) 从 Physalis 冬季樱 L 的花萼被孤立。var。francheti (桅杆) Makino。1 的结构借助于 1D 和 2D NMR 被决定,紫外,红外和集体系列。对 PC-3 和 LNCaP 房间线在 vitro 加重 1 显示的有势力 cytotoxicities。 | Chu Hang Zhang Zheng Tao Wang Yi Ping Yang Qi Shi Sun | 2009 | Chinese Chemical Letters2009，20，11： | 9 |
| 9 | Catalytic properties of Cu-Co catalysts supported on HNO_3-pretreated CNTs for higher-alcohol synthesis显示文摘HNO 3 -pretreated CNTs were employed as supports, and a special ultrasound-assisted impregnation method was designed to prepare supported Cu-Co catalysts for higher-alcohol synthesis from syngas. The catalysts used in this work were characterized by N 2 adsorption-desorption, TEM, XRD, H 2 -TPR, CO-TPD techniques. It was found that the pre-treatment procedure of CNTs remarkably promoted the catalytic properties of the Cu-Co/CNTs catalysts. For the Cu-Co catalyst supported on CNTs pre-treated by 68 wt% HNO 3 , some active components were introduced into the CNTs channels, their dispersions and the amount of strongly adsorbed CO-species were improved. The CO conversion and alcohol yield on the HNO 3 -pretreated Cu-Co/CNTs catalyst were increased by ~21% and ~69%, respectively, compared with those on the normal Cu-Co/CNTs catalyst. | Limin Shi Wei Chu Siyu Deng | 2011 | Journal of Natural Gas Chemistry2011，20，1： | 9 |
| 10 | Catalytic properties of Cu/Co/Zn/Zr oxides prepared by various methods显示文摘基于的新 Cu 公司(Cu/Co/Zn/Zr ) 为高白酒的合成的催化剂用一起沉淀方法被准备,血浆在超声照耀下面的提高的方法和反向的一起沉淀方法。催化剂被赌注, SEM, XRD, H 2-TPR 和 XPS 的工具调查。各种各样的方法准备的催化剂的催化性质用公司加氢反应被检验。血浆提高了方法,在超声照耀下面的反向的一起沉淀方法在提高 Cu/Co/Zn/Zr 的催化性质两个都是有效的,这被发现混合氧化物。小粒子尺寸,活跃部件的高分散,特定的表面区域的改进和活跃阶段的表面内容能说明试验性的 Cu/Co/Zn/Zr 催化剂的优秀表演。 | Limin Shi Wei Chu Siyu Deng Huiyuan Xu | 2008 | Journal of Natural Gas Chemistry2008，17，4： | 8 |
| 11 | Vehicle Planar Motion Stability Study for Tyres Working in Extremely Nonlinear Region显示文摘Many researches on vehicle planar motion stability focus on two degrees of freedom(2DOF) vehicle model,and only the lateral velocity (or side slip angle) and yaw rate are considered as the state variables.The stability analysis methods,such as phase plane analysis,equilibriums analysis and bifurcation analysis,are all used to draw many classical conclusions.It is concluded from these researches that unbounded growth of the vehicle motion during unstable operation is untrue in reality thus one limitation of the 2DOF model.The fundamental assumption of the 2DOF model is that the longitudinal velocity is treated as a constant,but this is intrinsically incorrect.When tyres work in extremely nonlinear region,the coupling between the vehicle longitudinal and lateral motion becomes significant.For the purpose of solving the above problem,the effect of vehicle longitudinal velocity on the stability of the vehicle planar motion when tyres work in extremely nonlinear region is investigated.To this end,a 3DOF model which introducing the vehicular longitudinal dynamics is proposed and the 3D phase space portrait method is employed for visualization of vehicle dynamics.Through the comparisons of the 2DOF and 3DOF models,it is discovered that the vehicle longitudinal velocity greatly affects the vehicle planar motion,and the vehicle dynamics represented in phase space portrait are fundamentally different from that of the 2DOF model.The vehicle planar motion with different front wheel steering angles is further represented by the corresponding vehicle route,yaw rate and yaw angle.These research results enhance the understanding of the stability of the vehicle system particularly during nonlinear region,and provide the insight into analyzing the attractive region and designing the vehicle stability controller,which will be the topics of future works. | LIU Li SHI Shuming SHEN Shuiwen CHU Jiangwei | 2010 | Chinese Journal of Mechanical Engineering2010，23，2： | 8 |
| 12 | A novel two-layered optical satellite network of LEO/MEO with zero phase factor显示文摘Optical satellite communication has advantages over the RF satellite communication in capacity, speed, secrecy and anti-interference.Space information superhighway composed of GEO/MEO/LEO satellites which are linked by optical inter-satellite links(OISL) would play important roles in communication, navigation, martial recon, remote sensing and deep space exploration.A novel LEO/MEO two-layered optical satellite network with global coverage is designed with the street-of-coverage technique.The layer of LEO satellites is the walker-delta constellation with zero phase factor and has the quasi-stable logical structure of Mesh.Equatorial and polar orbit satellites constitute the layer of MEO satellite, which can cover LEO layer effectively.Rising satellites of the system can provide 99.9% of coverage for the whole globe and 100% for China averagely.The network can provide a minimum elevation angle at 21 ? with single-satellite visibility for China, and at 16 ? with the dual-satellite visibility.Simulation results of the inter-satellite links show LEO constellation of zero phase factor outperforms non-zero phase factor constellations in azimuth angle, elevation angle and distance, which is very fit for the OISL.Simulation results of the communication performance indicate a little difference between short wave band and long wave band at low communication speed(several Gbit/s);however, the wave band at 1550 nm is a better choice at high communication speed(100 Gbit/s). | LI YongJun , WU JiLi, ZHAO ShangHong, MENG Wen, MA LiHua, SHI Lei, CHU XingChun, HOU Rui & LI Tian Telecommunication Engineering Institute, Air Force Engineering University, Xi’an 710077, China | 2010 | Science China(Information Sciences)2010，53，6： | 8 |
| 13 | The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST)显示文摘The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, also called the Guo Shou Jing Telescope) is a special reflecting Schmidt telescope. LAMOST's special design allows both a large aperture (effective aperture of 3.6 m-4.9 m) and a wide field of view (FOV) (5°). It has an innovative active reflecting Schmidt configuration which continuously changes the mirror's surface that adjusts during the observation process and combines thin deformable mirror active optics with segmented active optics. Its primary mirror (6.67m×6.05 m) and active Schmidt mirror (5.74m×4.40 m) are both segmented, and composed of 37 and 24 hexagonal sub-mirrors respectively. By using a parallel controllable fiber positioning technique, the focal surface of 1.75 m in diameter can accommodate 4000 optical fibers. Also, LAMOST has 16 spectrographs with 32 CCD cameras. LAMOST will be the telescope with the highest rate of spectral acquisition. As a national large scientific project, the LAMOST project was formally proposed in 1996, and approved by the Chinese government in 1997. The construction started in 2001, was completed in 2008 and passed the official acceptance in June 2009. The LAMOST pilot survey was started in October 2011 and the spectroscopic survey will launch in September 2012. Up to now, LAMOST has released more than 480 000 spectra of objects. LAMOST will make an important contribution to the study of the large-scale structure of the Universe, structure and evolution of the Galaxy, and cross-identification of multiwaveband properties in celestial objects. | Xiang-Qun Cui Yong-Heng Zhao Yao-Quan Chu Guo-Ping Li Qi Li Li-Ping Zhang Hong-Jun Su Zheng-Qiu Yao Ya-Nan Wang Xiao-Zheng Xing Xin-Nan Li Yong-Tian Zhu Gang Wang Bo-Zhong Gu A-Li Luo Xin-Qi Xu Zhen-Chao Zhang Gen-Rong Liu Hao-Tong Zhang De-Hua Yang Shu-Yun Cao Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Ying Chen Jia-Ru Chu Lei Feng Xue-Fei Gong Yong-Hui Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Lei Jia Fang-Hua Jiang Xiang Jiang Zi-Bo Jiang Ge Jin Ai-Hua Li Yan Li Ye-Ping Li Guan-QunLiu Zhi-Gang Liu Huo-Ming Shi Zheng-Hong Tang Qing-Sheng Tao Xiang-Yan Yuan Chao Zhai Jing Zhang Yan-Xia Zhang Yong Zhang Ming Zhao Fang Zhou Guo-Hua Zhou Jie Zhu Si-Cheng Zou | 2012 | Research in Astronomy and Astrophysics2012，12，9： | 8 |
| 14 | Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins显示文摘Most mammalian cells take up cholesterol from low-density lipoproteins(LDLs) via receptor-mediated endocytosis.After reaching lysosomes,LDL-derived cholesterol continues to transport to downstream organelles including the ER for specific structural and functional needs.Peroxisomes are recently found to receive cholesterol from lysosomes through lysosomeperoxisome membrane contacts.However,whether and how cholesterol is conveyed from peroxisomes to the ER remain unknown.Here,by combining high-resolution microscopic analyses and in vitro reconstitution of highly purified organelles or artificial liposomes,we demonstrate that peroxisomes form membrane contacts with the ER through the interaction between peroxisomal PI(4,5)P2 and ER-resident extended synaptotagmin-1,2 and 3(E-Syts).Depletion of peroxisomal PI(4,5)P2 or ESyts markedly decreases peroxisome-ER membrane contacts and induces cholesterol accumulation in lysosomes.Furthermore,we show that cholesterol is delivered from 3H-labeled peroxisomes or PI(4,5)P2-containing liposomes to the ER in vitro,and that the presence of peroxisomes augments cholesterol transfer from lysosomes to the ER.Together,our study reveals a new cholesterol transport pathway along the lysosome-peroxisome-ER membrane contacts in the cell. | Jian Xiao Jie Luo Ao Hu Ting Xiao Meixin Li Zekai Kong Luyi Jiang Zimu Zhou Yacheng Liao Chang Xie Beibei Chu Honghua Miao Boliang Li Xiongjie Shi Bao-Liang Song | 2019 | Science China(Life Sciences)2019，62，9： | 8 |
| 15 | Convergent genomic signatures of high-altitude adaptation among domestic mammals显示文摘Abundant and diverse domestic mammals living on the Tibetan Plateau provide useful materials for investigating adaptive evolution and genetic convergence.Here,we used 327 genomes from horses,sheep,goats,cattle,pigs and dogs living at both high and low altitudes,including 73 genomes generated for this study,to disentangle the genetic mechanisms underlying local adaptation of domestic mammals.Although molecular convergence is comparatively rare at the DNA sequence level,we found convergent signature of positive selection at the gene level,particularly the EPAS1 gene in these Tibetan domestic mammals.We also reported a potential function in response to hypoxia for the gene C10 orf67,which underwent positive selection in three of the domestic mammals.Our data provide an insight into adaptive evolution of high-altitude domestic mammals,and should facilitate the search for additional novel genes involved in the hypoxia response pathway. | Dong-Dong Wu Cui-Ping Yang Ming-Shan Wang Kun-Zhe Dong Da-Wei Yan Zi-Qian Hao Song-Qing Fan Shu-Zhou Chu Qiu-Shuo Shen Li-Ping Jiang Yan Li Lin Zeng He-Qun Liu Hai-Bing Xie Yun-Fei Ma Xiao-Yan Kong Shu-Li Yang Xin-Xing Dong Ali Esmailizadeh David M Irwin Xiao Xiao Ming Li Yang Dong Wen Wang Peng Shi Hai-Peng Li Yue-Hui Ma Xiao Gou Yong-Bin Chen Ya-Ping Zhang | 2020 | National Science Review2020，7，6： | 7 |
| 16 | Selective laser melting of near-α titanium alloy Ti-6Al-2Zr-1Mo-1V:Parameter optimization, heat treatment and mechanical performance显示文摘This paper presents a comprehensive study conducted to optimize the selective laser melting(SLM)parameters and subsequent heat-treatment temperatures for near-α high-temperature titanium alloy Ti-6 Al-2 Zr-1 Mo-1 V(TA15),which is widely used in the aerospace industry.Based on the surface morphology and relative density analysis,the optimized process parameters were:laser power from 230 W to 380 W,scan speed from 675 mm/s to 800 mm/s,scan spacing of 0.12 mm,and layer thickness of0.03 mm.The effects of the laser power and the layer thickness on the phase constitutions,microstructure features,as well as room-temperature and high-temperature(500℃) tensile properties,were then studied to obtain an in-depth understanding of SLM-built TA15.Six typical temperatures(650,750,850,950,1000 and 1100℃) covering three representative temperature ranges,i.e.,martensite partial decomposition temperature range,martensite complete decomposition temperature range and above βtransus temperature,were subsequently selected as heat-treatment temperatures.The heat treatmentmicrostructure-mechanical property relationships of SLM-built TA15 were elucidated in detail.These results provide valuable information on the development of SLM-built TA15 alloy for industrial applications,and these findings are also beneficial to additive manufacturing of other near-α Ti alloys with desirable high-temperature properties. | Chao Cai Xu Wu Wan Liu Wei Zhu Hui Chen Jasper Chu Dong Qiu Chen-Nan Sun Jie Liu Qingsong Wei Yusheng Shi | 2020 | Journal of Materials Science & Technology2020，54，22： | 7 |
| 17 | A sequence of 28S rRNA-derived small RNAs is enriched in mature sperm and various somatic tissues and possibly associates with inflammation显示文摘 | Chu, Chen Yu, Lu Wu, Bin Ma, Li Gou, Lan-Tao He, Miao Guo, Yunli Li, Zhi-Tong Gao, Wei Shi, Huijuan Liu, Mo-Fang Wang, Hongyan Chen, Charlie Degui Drevet, Joel R. Zhou, Yuchuan Zhang, Yonglian | 2017 | Journal of Molecular Cell Biology2017，9，3： | 6 |
| 18 | Chromosome-level genome of Himalayan yew provides insights into the origin and evolution of the paclitaxel biosynthetic pathway显示文摘Taxus,commonly known as yew,is a well-known gymnosperm with great ornamental and medicinal value.In this study,by assembling a chromosome-level genome of the Himalayan yew(Taxus wallichiana)with 10.9 Gb in 12 chromosomes,we revealed that tandem duplication acts as the driving force of gene family evolution in the yew genome,resulting in the main genes for paclitaxel biosynthesis,i.e.those encoding the taxadiene synthase,P450s,and transferases,being clustered on the same chromosome.The tandem duplication may also provide genetic resources for the nature to sculpt the core structure of taxoids at different positions and subsequently establish the complex pathway of paclitaxel by neofunctionalization.Furthermore,we confirmed that there are two genes in the cluster encoding isoenzymes of a known enzyme in the paclitaxel biosynthetic pathway.The reference genome of the Himalayan yew will serve as a platform for decoding the complete biosynthetic pathway of paclitaxel and understanding the chemodi-versity of taxoids in gymnosperms. | Jian Cheng Xiao Wang Xiaonan Liu Xiaoxi Zhu Zihe Li Huanyu Chu Qian Wang QianQian Lou Bijun Cai Yiqun Yang Xiaoyun Lu Kai Peng Dingyu Liu Yuwan Liu Lina Lu Huan Liu Ting Yang Qijin Ge Chengcheng Shi Guichun Liu Zhiwei Dong Xun Xu Wen Wang Huifeng Jiang Yanhe Ma | 2021 | Molecular Plant2021，14，7： | 6 |
| 19 | Receptor activator of NF-κB Ligand (RANKL) expression is associated with epithelial to mesenchymal transition in human prostate cancer cells显示文摘 | Valerie A Odero-Marah Ruoxiang Wang Gina Chu Majd Zayzafoon Jianchun Xu Chunmeng Shi Fray F Marshall Haiyen E Zhau Leland WK Chung | 2008 | Cell Research2008，18，8： | 6 |
| 20 | Production of thick-walled hollow glass microspheres for inertial confinement fusion targets by sol-gel technology显示文摘To fabricate thick-walled hollow glass microspheres(HGMs)for inertial confinement fusion(ICF)targets by sol-gel technology,we investigated the effects of glass composition,blowing agent,refining temperature,pressure and composition of furnace atmosphere on the wall thickness of HGMs by numerical simulation and experiments.The results showed that the residence times of the thick-walled HGMs in the encapsulating and refining phases decreased with the increase of wall thickness of HGMs.As a response to this challenge,glass composition must be optimized with the object of high surface tension and low viscosity at refining temperature,and the blowing agents with high decomposition temperature should be used,furthermore the concentration of blowing agents in gel particles must also be precisely controlled.The higher volume fraction of argon gas in the furnace atmosphere,the thicker the wall of HGMs.Due to the limited operating range of furnace atmosphere pressure,changing furnace atmosphere pressure could not significantly increase the wall thickness of HGMs.Although increasing refining temperature can improve the yield of high quality HGMs,a higher furnace atmosphere temperature may lead to a decrease in the wall thickness of HGMs.When the volume fraction of argon gas in the furnace atmosphere ranged from 80%to 95%,the furnace atmosphere pressure ranged from 1.0×105Pa to 1.25×105 Pa,and the refining temperature ranged from 1600°C to 1800°C,we produced thick-walled(5–10-m)HGMs with good sphericity,wall thickness uniformity and surface finish.However,the yield of high quality HGMs needs to be further improved.The compressive strength,tensile strength and permeation coefficient to deuterium gas of thick-walled HGMs at ambient temperature decreased with increase of the wall thickness. | GAO Cong QI XiaoBo WEI Sheng ZHANG ZhanWen LI Bo SHI Tao CHU QiaoMei | 2011 | Science China(Technological Sciences)2011，54，9： | 6 |
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