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| 1 | A novel superhard tungsten nitride predicted by machine-learning accelerated crystal structure search显示文摘Transition metal nitrides have been suggested to have both high hardness and good thermal stability with large potential application value,but so far stable superhard transition metal nitrides have not been synthesized.Here,with our newly developed machine-learning accelerated crystal structure searching method,we designed a superhard tungsten nitride,h-WN_6,which can be synthesized at pressure around65 GPa and quenchable to ambient pressure.This h-WN_6is constructed with single-bonded armchair-like N_6rings and presents ionic-like features,which can be formulated as W^(2.4+)N_6^(2.4à).It has a band gap of1.6 e V at 0 GPa and exhibits an abnormal gap broadening behavior under pressure.Excitingly,this h-WN_6is found to be the hardest among transition metal nitrides known so far(Vickers hardness around57 GPa)and also has a very high melting temperature(around 1,900 K).Additionally,the good gravimetric(3.1 k J/g)and volumetric(28.0 k J/cm^3)energy densities make this nitrogen-rich compound a potential high-energy-density material.These predictions support the designing rules and may stimulate future experiments to synthesize superhard and high-energy-density material. | Kang Xia Hao Gao Cong Liu Jianan Yuan Jian Sun Hui-Tian Wang Dingyu Xing | 2018 | Science Bulletin2018，63，13： | 11 |
| 2 | Pathological and molecular examinations of postmortem testis biopsies reveal SARS-CoV-2 infection in the testis and spermatogenesis damage in COVID-19 patients显示文摘In late December 2019,the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes coronavirus disease 2019(COVID-19),was identified in Wuhan,China,and the ensuing pandemic has led to more than 50 million infected individuals and more than one million deaths by November 10,2020(http://gffzze7c39cdc9e894ca6s5pf05qn65nuw6cnf.ffgz.tsg.suse.edu.cn/).Pathologic investigations of autopsy tissue have focused primarily on the lung,heart,and kidney,whereas morphologic data on testis injury and the effects of SARS-CoV-2 infection on spermatogenesis are limited.Although two groups did not detect SARS-CoV-2 in the semen or testes of recovered COVID-19 patients,1,2 another group confirmed SARS-CoV-2 in the semen of patients.3 Therefore,it is currently unknown whether SARS-CoV-2 infection impacts spermatogenesis and male fertility.In the present study,we evaluated the effects of SARS-CoV-2 infection on spermatogenesis by examining the pathophysiology and molecular features of testes obtained from five male COVID-19 patients at autopsy. | Xixiang Ma Chuhuai Guan Rong Chen Yunyun Wang Shenglei Feng Rongshuai Wang Guoqiang Qu Sijia Zhao Fengli Wang Xiaoli Wang Dingyu Zhang Liang Liu Aihua Liao Shuiqiao Yuan | 2021 | Cellular & Molecular Immunology2021，18，2： | 6 |
| 3 | Chromosome-level genome of Himalayan yew provides insights into the origin and evolution of the paclitaxel biosynthetic pathway显示文摘Taxus,commonly known as yew,is a well-known gymnosperm with great ornamental and medicinal value.In this study,by assembling a chromosome-level genome of the Himalayan yew(Taxus wallichiana)with 10.9 Gb in 12 chromosomes,we revealed that tandem duplication acts as the driving force of gene family evolution in the yew genome,resulting in the main genes for paclitaxel biosynthesis,i.e.those encoding the taxadiene synthase,P450s,and transferases,being clustered on the same chromosome.The tandem duplication may also provide genetic resources for the nature to sculpt the core structure of taxoids at different positions and subsequently establish the complex pathway of paclitaxel by neofunctionalization.Furthermore,we confirmed that there are two genes in the cluster encoding isoenzymes of a known enzyme in the paclitaxel biosynthetic pathway.The reference genome of the Himalayan yew will serve as a platform for decoding the complete biosynthetic pathway of paclitaxel and understanding the chemodi-versity of taxoids in gymnosperms. | Jian Cheng Xiao Wang Xiaonan Liu Xiaoxi Zhu Zihe Li Huanyu Chu Qian Wang QianQian Lou Bijun Cai Yiqun Yang Xiaoyun Lu Kai Peng Dingyu Liu Yuwan Liu Lina Lu Huan Liu Ting Yang Qijin Ge Chengcheng Shi Guichun Liu Zhiwei Dong Xun Xu Wen Wang Huifeng Jiang Yanhe Ma | 2021 | Molecular Plant2021，14，7： | 6 |
| 4 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 5 | Coexistence of plastic and partially diffusive phases in a helium-methane compound显示文摘Helium and methane are major components of gian icy planets and are abundant in the universe.However,helium is the most inert element in the periodic table and methane is one of the most hydrophobic molecules,thus whether they can react with each other is of fundamental importance.Here,our crystal structure searches and first-principles calculations predict that a He3CH4 compound is stable over a wide range of pressures from 55 to 155 GPa and a HeCH4 com pound becomes stable around 105 GPa.As nice examples of pure van der Waals crystals;the insertion of helium atoms changes the original packing of pure methane molecules and also largely hinders the polymerization of methane at higher pressures.After analyzing the diffusive properties during the melting of He3CH4 at high pressure and high temperature,in addition to a plastic methane phase,we have discovered an unusual phase which exhibits coexistence of diffusive helium and plastic methane.In addition,the range of the diffusive behavior within the helium-methane phase diagram is found to be much narrower compared to that of previously predicted helium-water compounds.This may be due to the weaker van der Waals interactions between methane molecules compared to those in helium-water compounds;and that the helium-methane compound melts more easily. | Hao Gao Cong Liu Andreas Hermann Richard J.Needs Chris J.Pickard Hui-Tian Wang Dingyu Xing Jian Sun | 2020 | National Science Review2020，7，10： | 4 |
| 6 | COVID-19-associated monocytic encephalitis(CAME):histological and proteomic evidence from autopsy显示文摘Severe neurological symptoms are associated with Coronavirus disease 2019(COVID-19).However,the morphologic features,pathological nature and their potential mechanisms in patient brains have not been revealed despite evidence of neurotropic infection.In this study,neuropathological damages and infiltrating inflammatory cells were quantitatively evaluated by immunohistochemical staining,ultrastructural examination under electron microscopy,and an image threshold method,in postmortem brains from nine critically ill COVID-19 patients and nine age-matched cadavers of healthy individuals.Differentially expressed proteins were identified by quantitative proteomic assays.Histopathological findings included neurophagocytosis,microglia nodules,satellite phenomena,extensive edema,focal hemorrhage,and infarction,as well as infiltrating mononuclear cells.Immunostaining of COVID-19 brains revealed extensive activation of both microglia and astrocytes,severe damage of the blood-brain barrier(BBB)and various degrees of perivascular infiltration by predominantly CD14+/CD16+/CD141+/CCR7+/CD11c+monocytes and occasionally CD4+/CD8+T lymphocytes.Quantitative proteomic assays combined with bioinformatics analysis identified upregulated proteins predominantly involved in immune responses,autophagy and cellular metabolism in COVID-19 patient brains compared with control brains.Proteins involved in brain development,neuroprotection,and extracellular matrix proteins of the basement membrane were downregulated,potentially caused by the activation of transforming growth factorβreceptor and vascular endothelial growth factor signaling pathways.Thus,our results define histopathological and molecular profiles of COVID-19-associated monocytic encephalitis(CAME)and suggest potential therapeutic targets. | Pei-Pei Zhang Zhi-Cheng He Xiao-Hong Yao Rui Tang Jie Ma Tao Luo Chuhong Zhu Tian-Ran Li Xindong Liu Dingyu Zhang Shuyang Zhang Yi-Fang Ping Ling Leng Xiu-Wu Bian | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 3 |
| 7 | Digital medical education empowered by intelligent fabric space显示文摘Medical education plays an important role in promoting the development of global medical science.Nevertheless,the intrinsic gap existing between institutional medical teaching and practical clinical tasks causes low education efficiency and students’weak initiative.Recent developments of sensing fabric and embedded computing,along with the advances in artificial intelligence(AI)and digital twin technology are paving the way for the transformation of medical research towards digitization.In this work,we present an intelligent fabric space based on novel functional fabric materials and digital twin networking enabled by 5G and internet of things(IoT)technologies.In this space,medical students can learn knowledge with collaborative mapping of the digital and real world,cyber-physical interaction and real-time tactile feedback.And the proposed service system will evaluate and feedback students’operational behaviors to improve their experimental skills.We provide four typical applications of intelligent fabric space for medical education,including medical education training,health and behavior tracking,operation playback and reproduction,as well as medical knowledge popularization.The proposed intelligent fabric space has the potential to promote innovative technologies for training cutting-edge medical students by effective and efficient ways. | Min Chen Rui Wang Rui Wang Yingting Zhou Zicheng He Xiaojuan Liu Muyao He Jiaxi Wang Chaolin Huang Huamin Zhou Ping Hong Chong Hou Ning Zhou Dingyu Zhang Guangming Tao | 2022 | National Science Open2022，1，1： | 2 |
| 8 | Computer Simulation of Radiotherapy Dose Distribution in Tissue显示文摘 | Yanmei Liu Dingyu Xue Xinhe Xu | 2006 | Proceedings of the 6th World Congress on Intelligent Control and Automation2006，，7： | 1 |
| 9 | Electromagnetic fields from a horizontal electrical dipole buried in ocean显示文摘Marine controlled source electromagnetic signal could be used in mineral resource exploration,reservoir appraisal and communicative technique in ocean. It's necessary to study the electromagnetic generated by MCSEM. The propagation of the electromagnetic fields from a controlled source in the marine environment was studied with virtual interface method combined with discrete complex image method. Transmitter of finite length current source is approximated by dipole (HED) . A three-layered model is accepted,with sea water as intermediate conductive layer under air and a relatively high resistive seabed as basement,possibly containing a hydrogen layer of higher resistivity. The electromagnetic fields in whole space thus computed show that: (1) the spatial distribution of field component depends on its type; (2) inline Ex component is more sensitive to reservoir layer than that in broadside; (3) The airwave affects marine electromagnetic (MEM) exploration when sea water is relatively shallow; in the case of deep water MEM exploration,the airwave influence could be neglected; and (4) an appropriate frequency should be selected in order to balance the signal strength and electromagnetic induction effect. | JIA Dingyu WENG Aihua LIU Yunhe YIN Changchun | 2012 | Global Geology2012，15，2： | 1 |
| 10 | Genetic polymorphism of interleukin-6 influences susceptibility to HBV-related hepatocellular carcinoma in a male Chinese Han population显示文摘 | Shengli Tang Yufeng Yuan Yueming He Dingyu Pan Yongxi Zhang Yuanyuan Liu Quanyan Liu Zhonglin Zhang Zhisu Liu | 2014 | Human Immunology2014，，4： | 1 |
| 11 | Metallic Aluminum Suboxides with Ultrahigh Electrical Conductivity at High Pressure显示文摘Aluminum,as the most abundant metallic elemental content in the Earth's crust,usually exists in the form of alumina(Al_(2)O_(3)).However,the oxidation state of aluminum and the crystal structures of aluminum oxides in the pressure range of planetary interiors are not well established. | Tianheng Huang Cong Liu Junjie Wang Shuning Pan Yu Han Chris J.Pickard Ravit Helled Hui-Tian Wang Dingyu Xing Jian Sun | 2023 | Research2023，，2： | 0 |
| 12 | Preparation of Eco-Friendly High-Performance Manganese Dioxide Supercapacitors by Linear Sweep Voltammetry显示文摘In this paper,the non-polluting,non-toxic,and eco-friendly material-MnO_(2)electrodes were deposited on three-dimensional porous nickel(Ni)foam by linear sweep voltammetry,and the entire electrodeposition process did not require sintering of the material,which was fast and convenient while avoiding unnecessary energy consump-tion and thus was environmentally friendly.Scanning electron microscopy(SEM)and transmission electron microscopy were used to examine the surface and microscopic characteristics of each sample(TEM).Chronoam-perometry(CA),cyclic voltammetry(CV),galvanostatic charge/discharge(GCD),and electrochemical impedance spectroscopy(EIS)were then used to determine the electrochemical characteristics of the manufactured samples.The result suggests that the MnO_(2)-sv80 electrode sample at a scan rate of 80 mV/s^(−1)has excellent performance for the supercapacitor electrode.The specific capacitance was as high as 531.4 F g^(−1)at a current density of 1 A g^(−1)and remained at 223.2 F g^(−1)at an ultra-high current density of 20 A g^(−1),with capacitance retention of 42%. | Junshan Zhao Yihan Shi Ming Zhang Liu Zhang Xumei Cui Xinghua Zhu Jitong Su Dandan Jing Dingyu Yang | 2023 | Journal of Renewable Materials2023，11，1： | 0 |
| 13 | Leflunomide: A versatile additive for defect reduction, enhanced optoelectronic properties and environmental stability of perovskite films显示文摘The development of perovskite photoelectric devices with excellent performance is largely dependent on the defects in the perovskite films.To address this issue,a specific drug,leflunomide(LF,C_(12)H_(9)F_(3)N_(2)O_(2)),was incorporated into the perovskite to reduce defects and improve its photoelectric properties.It is believed that the C=O bond on LF molecule can interact with the uncoordinated Pb2+of the perovskite,thereby reducing non-radiative recombination.This novel approach of incorporating LF into perovskite films has the potential to revolutionize the development of high-performance perovskite photoelectric devices.The trifluoromethyl functional(–CF_(3))group on LF can form a protective layer on the surface of the perovskite film,shielding it from water erosion.Moreover,LF can be utilized to alter the nucleation position of perovskite,thus minimizing the number of defects and optimizing the film quality.Consequently,the LF-doped perovskite film displays low trap density and high photoelectric performance.The LF-doped perovskite film showed a trap density of 8.28×10^(11),which is notably lower than the 2.04×10^(12) of the perovskite film without LF.The responsivity and detectivity of the LF-doped perovskite photodetector were 0.771 A/W and 2.81×10^(11) Jones,respectively,which are much higher than the 0.23 A/W and 1.06×10^(10) Jones of the LF-undoped perovskite photodetector.Meanwhile,the LF-doped photodetector maintained an initial photocurrent of 86%after 30 days of storage in air,indicating drastically increased environmental stability.This strongly suggests that LF is an effective additive for perovskites utilized in optoelectronic devices with high performance. | Dingyue Sun Ming Peng Taijin Wang Longju Yi Shizuo Zhang Feng Liu Gary J.Cheng | 2024 | Nano Research2024，17，4： | 0 |
| 14 | Feasibility Study of Mixing Throat Swab Samples for Severe Acute Respiratory Syndrome Coronavirus-2 Screening显示文摘Dear Editor,The outbreak of coronavirus disease 2019(COVID-19)has been declared a pandemic by the World Health Organization(WHO)and has resulted in the worst public health crisis since World War II(Wang et al.2020). | Yang Han Qingyu Yang Ying Liu Ting Shu Li Yue Ting Xiao Qin Zeng Ying Wu Xi Zhou Dingyu Zhang | 2020 | Virologica Sinica2020，35，6： | 0 |
| 15 | Triazine-based multicomponent metallacages with tunable structures for SO_(2) selective capture and conversion显示文摘The design of novel materials for sulfur dioxide(SO_(2))capture and conversion with considerable efficiency under mild conditions is of great significance for human health and environmental protection yet highly challenging.Herein,we report a series of triazine-based multicomponent metallacages via coordination-driven self-assembly of 2,4,6-tri(4-pyridyl)-1,3,5-triazine,cis-Pt(PEt3)2(OTf)2 and different tetracarboxylic ligands.As the increase of the length of the tetracarboxylates,the structures of the metallacages change from pyramids to extended octahedrons.Owing to their N-rich structure,these metallacages are further used for selective SO_(2)capture,showing good adsorption capacity and remarkable SO_(2)/CO_(2)selectivity in ambient conditions,suggesting their potential applications toward real flue gas desulfurization.The metallacages are further employed for the conversion of SO_(2)into value-added compounds,showing exceptional efficiency even dilute SO_(2)is used as the reactant.This study represents a type of structure-tunable triazinebased metallacages for SO_(2)capture and conversion,which will pave the way on the applications of metal-organic complexes for gas adsorption. | Ruoqian Zhang Dingyue Hu Yu Fu Qian Feng Chaoqun Mu Kai Gao Heping Ma Ming Liu Mingming Zhang | 2024 | Aggregate2024，5，1： | 0 |
| 16 | Enhanced cathodic activity by tantalum inclusion at B-site of La_(0.6)Sr_(0.4)Co_(0.4)Fe_(0.6)O_(3)based on structural property tailored via camphor-assisted solid-state reaction显示文摘Lanthanum strontium cobalt ferrite(LSCF)is an appreciable cathode material for solid oxide fuel cells(SOFCs),and it has been widely investigated,owing to its excellent thermal and chemical stability.However,its poor oxygen reduction reaction(ORR)activity,particularly at a temperature of≤800℃,causes setbacks in achieving a peak power density of>1.0 W·cm^(-2),limiting its application in the commercialization of SOFCs.To improve the ORR of LSCF,doping strategies have been found useful.Herein,the porous tantalum-doped LSCF materials(La_(0.6)Sr_(0.4)Co_(0.4)Fe_(0.5)7Ta_(0.03)O_(3)(LSCFT-0),La_(0.6)Sr_(0.4)Co_(0.4)Fe_(0.5)4Ta0.06O_(3),and La_(0.6)Sr_(0.4)Co_(0.4)Fe_(0.5)Ta0.1O_(3))are prepared via camphor-assisted solid-state reaction(CSSR).The LSCFT-0 material exhibits promising ORR with area-specific resistance(ASR)of 1.260,_(0.5)80,0.260,0.100,and 0.06Ω·cm^(2)at 600,650,700,750,and 800℃,respectively.The performance is about 2 times higher than that of undoped La_(0.6)Sr_(0.4)Co_(0.4)Fe_(0.6)O_(3)with the ASR of 2.515,1.191,_(0.5)96,0.320,and 0.181Ω·cm^(2)from the lowest to the highest temperature.Through material characterization,it was found that the incorporated Ta occupied the B-site of the material,leading to the enhancement of the ORR activity.With the use of LSCFT-0 as the cathode material for anode-supported single-cell,the power density of>1.0 W·cm^(-2)was obtained at a temperature<800℃.The results indicate that the CSSR-derived LSCFT is a promising cathode material for SOFCs. | Dingyu XIONG Sefiu Abolaji RASAKI Yangpu LI Liangdong FAN Changyong LIU Zhangwei CHEN | 2022 | Journal of Advanced Ceramics2022，11，8： | 0 |
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