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| 1 | Anti-hypertensive drugs in children and adolescents显示文摘Worldwide the prevalence of essential hypertension inchildren and adolescents continues to increase. Tradi-tionally providers have used 'off-label' drugs to treatpediatric hypertension, meaning that rigorous clinicaltrials of these drugs have not been specifically per-formed in pediatric patient populations. Consequentlyproviders have extrapolated dosing, safety and efficacyfrom trials in adults. This practice is sub-optimal as chil-dren demonstrate unique differences in drug metabo-lism and response. Use of unstudied or understudieddrugs increases risk of adverse events and/or can leadto sub-optimal efficacy. Recognizing these concerns,regulatory agencies have created financial incentivesfor industry to conduct pediatric clinical trials. Theseincentives, coupled with the emerging pediatric hyper-tension epidemic, have spurred over 30 clinical trialsof anti-hypertensive drugs over the past 15 years andhave resulted in labeling of 10 new drugs by the UnitedStates Food and Drug Administration for treatment ofhypertension in children and adolescents. Unfortunatelythe financial incentive structures focus on newer drugsand drug classes. Consequently there is now a relativedearth of trial data for older but sometimes commonlyprescribed pediatric antihypertensive drugs. This article reviews recent pediatric antihypertensive drug trials with a focus on trial design and endpoints, drug dosing, safety, efficacy and specific drug indications. We also review the available data and experience for some of the more commonly prescribed, but less well studied 'older' pediatric antihypertensive drugs. | Patricia Y Chu Michael J Campbell Stephen G Miller Kevin D Hill | 2014 | World Journal of Cardiology2014，6，5： | 2 |
| 2 | Faraday current sensor that uses a triangular-shaped bulk-optic sensing element 显示文摘 | CHU B C B NING Y N JACKSON D A | 1992 | Opt Lett1992，17，16： | 2 |
| 3 | Characterizations on 2-i- sometries显示文摘 | Chu H Y Ku S H Kang D S | 2008 | Journal of Mathematic Analysis and Appli- cation2008，340，： | 1 |
| 4 | High level of Notch1 protein is associated with poor overall survival in colorectal cancer显示文摘 | Chu D Li Y Wang W | 2010 | Ann Surg Oncol2010，17，5： | 1 |
| 5 | Fano resonance and spectral compression i n a ring resonator drop filter with feedback显示文摘 | Lu Y Fu X Chu D | 2011 | Optics Communications2011，284，1： | 1 |
| 6 | Band to band optical absorption in narrow gap Hg:-xCdxTe semiconductors显示文摘 | J H Chu Z Y Mi D Y Tang | 1992 | J Appl Phys1992，71，8： | 1 |
| 7 | Matrix metalloproteinase-9 is as- sociated with relapse and prognosis of patients with colorectal canc- er显示文摘 | Chu D Zhao Z Zhou Y | 2012 | Ann Surg Oncol2012，19，1： | 1 |
| 8 | Identification of complex vertebral malformation carriers in Chinese Holstein 显示文摘 | Chu Q Sun D X Yu Y | 2008 | J Vet Diagn Invest2008，20，2： | 1 |
| 9 | Cryptic invasion of the exotic Bemisia tabaci biotype Q occurred widespread in Shandong Province of China显示文摘 | Chu D Zhang Y J Wan F H | 2010 | Florida Entomologist2010，93，： | 1 |
| 10 | Inertia and rank characterizations of some matrixexpressions 显示文摘 | Chu D L Hung Y S Woerdeman H J | 2009 | SIAM J Matrix Anal Appl2009，31，： | 1 |
| 11 | Temperature-dependent molecular-recognizable membranes based on poly(N-isopropylacrylamide) and ,B-cyclodextrin显示文摘 | Xie R Zhang S B Wang H D Yang M Li P F Zhu X L Chu L Y | 2009 | Journal of Membrane Science2009，326，2： | 1 |
| 12 | 显示文摘 | Jiang D Zhang Y Chu H | 2014 | RSC Advances2014，31，4： | 1 |
| 13 | A novel thermo-responsive membrane for chiral resolution显示文摘 | Yang M Chu L Y Wang H D Xie R Song H Niu C H | 2008 | Advanced Functional Materials2008，18，4： | 1 |
| 14 | Adakites from continental collision zones: Melting of thickened lower crust beneath southern Tibet 显示文摘 | Chung S L Liu D Y Ji J Q Chu M F Lee H Y Wen D J Lo C H Lee T Y Qian Q Zhang Q | 2003 | Geology2003，31，11： | 1 |
| 15 | Surveillance for thrombocytopenia in persons infected with HIV: results from the multistate adult and adolescent spectrum of disease project显示文摘 | SULLIVAN P S HANSON D L CHU S Y | 1997 | J Acquir Immune Defic Syndr Hum Retrovirol1997，14，4： | 1 |
| 16 | Prediction of colorectal cancer relapse and prognosis by tissue mRNA levels of NDRG2 显示文摘 | Chu D Zhang Z Li Y | 2011 | Mol Cancer Ther2011，10，1： | 1 |
| 17 | A note on optimal procurement contracts with limited direct cost inflation 显示文摘 | Chu L Y Sappington D | 2007 | Journal of Economic Theory2007，137，1： | 1 |
| 18 | On-chip CMOS-compatible all-optical integrator显示文摘 | Ferrera M Park Y Razzari L Little B E Chu S T Morandotti R Moss D J Aza(n)a J | | 0，，29： | 1 |
| 19 | Synthesis and characterization of biodegradable poly( L -aspartic acid- co -PEG)显示文摘 | Won C Y Chu C C Lee J D | 1998 | J Polym Sci Polym Chem1998，36，： | 1 |
| 20 | Faraday current sensor that uses a train gular-shaped bulk-optic sensing element显示文摘 | CHU B C NING Y N JACKSON D A | 1992 | Opt Lett1992，17，16： | 1 |
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