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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries显示文摘one-bead-one-compound (OBOC ) 组合的肽图书馆是一个强大的工具识别 ligand 和受体相互作用。这里,我们使用了 OBOC 图书馆技术识别对主要贝壳变应原 tropomyosin 的免疫球蛋白 E (IgE ) epitopes 特定的 mimotopes。有 8-12 氨基酸残余的 OBOC 肽图书馆为 tropomyosin 的 IgE mimotopes 与贝壳过敏症从病人与浆液样品被屏蔽。25 mimotopes 从屏蔽被识别,他们到 tropomyosin 特定的 IgE 的有约束力的反应被肽 ELISA 证实。这些 mimotopes 能基于顺序相同被划分成七簇,并且由聚类的 mimotopes 的 EpiSearch 印射的 epitope 被执行描绘并且证实 mimotopes 的有效性。五从六预言的 epitopes 被发现与 tropomyosin 的以前识别的 epitopes 重叠。为了推进,证实 mimotopes 的模仿潜力, BALB/c 老鼠被使免疫, mimotopes 结合了到锁眼恋栈者 hemocyanin 和 assayed 让他们的能力导致 tropomyosin 特定的抗体。那收到的 mimotope 免疫被发现有 tropomyosin 特定的免疫球蛋白 G 的提高的水平的 BALB/c 老鼠,然而并非收到了无关的 mimotope 的老鼠。这研究用整个 sera 开创 OBOC 图书馆的成功的申请屏蔽并且识别多重虾变应原 mimotopes 并且验证他们在 vitro 使用的模仿潜力,在 vivo,并且在 silico 方法。 | Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 3 | SPARC is associated with gastric cancer progression and poor survival of patients显示文摘 | Zhao ZS Wang YY Chu YQ | 2010 | Clin Cancer Res2010，16，1： | 1 |
| 4 | Spindle cell carcinoma of the oral cavity and omphatynx: factors affecting outcome 显示文摘 | Su HH Chu ST Hou YY | 2006 | J Chin Meal Assoc2006，69，10： | 1 |
| 5 | Diagnostic methods for initial evaluation of primary gastrointestinal stromal tumors显示文摘 | Chu YY Lien JM Ng SC | 2010 | Saudi Med J2010，31，3： | 1 |
| 6 | Intravenous leiomyomatosis:computed tomography diagnosis显示文摘 | Wong YY Chu WC Lam WW | 2006 | Hong Kong Med J2006，12，3： | 1 |
| 7 | Modified endoscopic submucosal dissection with enucleation for treatment of gastric subepithelial tumors originating from the muscularis propria layer 显示文摘 | Chu YY Lien JM Tsai MH | 2012 | BMC Gastroenterol2012，12，： | 1 |
| 8 | NAT2 slow acetylation haplotypes are associated with the increased risk of betel quid-related oral and pharyngeal squamous cell carcinoma 显示文摘 | Hou YY Ou HL Chu ST | 2011 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2011，112，4： | 1 |
| 9 | No significant association of Epstein- Barr virus infection with invasive breast carcinoma 显示文摘 | Chu PG Chang KL Chen YY | 2001 | Am J Pathol2001，159，2： | 1 |
| 10 | SPARC is associated withgastric cancer progression and poor survival of patients显示文摘 | Zhao ZS Wang YY Chu YQ | 2010 | ClinCancer Res2010，16，1： | 1 |
| 11 | No significant association of Epstein-Barr virus infection with invasive breast carcinoma显示文摘 | Chu PG Chang KL Chen YY | 2001 | Pathology2001，159，2： | 1 |
| 12 | SPARC is associated with gastric cancer progression and poor survival of patiems显示文摘 | Zhao ZS Wang YY Chu YQ | 2010 | Clin Cancer Res2010，16，1： | 1 |
| 13 | Overexpression of matrix metaUoproteinase 11 in human gastric carcinoma and its clinicopathologic significance 显示文摘 | ZHAO ZS CHU YQ YE ZY WANG YY TAO HQ | 2010 | Hum Pathol2010，41，5： | 1 |
| 14 | Differentiation of ankle sprain motion and common sporting motion by ankle inversion velocity显示文摘 | Chu VWS Fong DTP Chan YY | | 0，，10： | 1 |
| 15 | Atypical presentation of lymphangioleiomyomatosis as acute abdomen:CT diagnosis显示文摘 | Wong YY Yeung TK Chu WC | 2003 | AJR Am J Roentgenol2003，181，1： | 1 |
| 16 | Spontaneous pneumomediastinum in patients with severe acute respiratory syndrome 显示文摘 | Chu CM Leung YY Hui JY | 2004 | Eur Respir J2004，23，6： | 1 |
| 17 | Incidence and predictors of falls in the Chinese elderly 显示文摘 | Chu LW Chi I Chiu YY | 2005 | Ann Acad Med2005，34，： | 1 |
| 18 | Spontaneous pneumomediastinum in patients with severe acute respiratory syndrome 显示文摘 | Chu CM Leung YY Hut JY | 2004 | Eur Respir J2004，23，6： | 1 |
| 19 | Induction of apoptosis by esculetin in human leukemia cells 显示文摘 | Chu CY Tsai YY Wang CJ | 2001 | Eur J Pharmacol2001，416，12： | 1 |
| 20 | No direct role for Epstein-Barr virus in American hepatocellular carcinoma显示文摘 | Chu PG Chen YY Chen W | 2001 | Am J Pathol2001，159，4： | 1 |
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