2篇
您的检索式：作者名="Chuanbing Shi"
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| 1 | Laparoscopic abdomino-perineal resection for patients with anorectal malignant melanoma:a report of 4 cases显示文摘Anorectal malignant melanoma is a very rare but lethal disease.Patients with anorectal malignant melanoma commonly complain for changes in bowel habits and rectal bleeding.Therefore,anorectal malignant melanoma is often misdiagnosed as hemorrhoids,polyp or rectal cancer.Surgery is the mainstay of treatment for patients with anorectal malignant melanoma.However,whether abdominoperineal resection or wide local excision is the most appropriate surgical approach is still a controversial issue.Recently,with the great development of laparoscopic techniques,more and more operations can be performed by laparoscopic techniques.However,laparoscopic abdominoperineal resection for management of anorectal malignant melanoma has been rarely reported.In this study,we reported 4 patients with anorectal malignant melanoma underwent laparoscopic abdominoperineal resection.The outcomes of these patients were relatively good during a long time follow-up.Meanwhile,we reviewed the relevant studies with particular focus surgical treatment. | Jun Han Chuanbing Shi Xiaogang Dong Jie Wang Hao Wen Baolin Wang Zhenyu He | 2016 | The Journal of Biomedical Research2016，30，5： | 3 |
| 2 | The potential of carcinoembryonic antigen,p53,Ki-67 and glutathion Stransferase-π as clinico-histopathological markers for colorectal cancer显示文摘Objective:Colorectal cancer is one of the major contributors to cancer death worldwide.Lack of reliable colorectal cancer markers has hampered the management of these cancer patients.Our main purpose was to study the correlation between histopathological variables of colorectal adenocarcinomas and identify histopathological markers that are of prognostic value in patients with colorectal cancer.Methods:In the present study,we examined the expression of carcinoembryonic antigen(CEA),p53,Ki-67 and glutathion Stransferase(GST)-πby using immunohistochemical staining methods in 126 colorectal carcinoma patients and evaluated the lymph node metastasis status in these patients by histopathological examination.Results:The positive rates of CEA,p53, Ki-67 and GST-πexpression in the colorectal cancer tissue specimens examined were 95.23%,55.56%,53.38% and 82.30%,respectively.Expression of p53 and Ki-67 was significantly correlated with the Dukes stages of the tumor,with higher levels of these proteins in Dukes'C and D tumors than those in Dukes'A and B tumors. Furthermore,the expression of p53,GST-πand Ki-67 correlated with prognosis of patients with colorectal cancer. Additionally,the expression of p53 in colorectal cancer was closely related to the expression of Ki-67 and the expression of GST-πwas directly correlated with that of p53.Conclusion:The expression of CEA,p53,Ki-67 and GST-πwas correlated with various clinical features of patients with colorectal cancer.The combined use of these histopathological markers appeared to be a promising tool in predicting the prognosis of patients with this type of cancer. | Zhenyu He Chuanbing Shi Hao Wen Fanglong Li Baolin Wang Jie Wang | 2010 | The Journal of Biomedical Research2010，24，1： | 1 |
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