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| 1 | Inhibition of apoptosis by oncogenic hepatitis B virus X protein: Implications for the treatment of hepatocellular carcinoma显示文摘Hepatitis B virus X protein(HBx) plays an important role in the development of hepatocellular carcinoma(HCC). In addition, hepatoma upregulated protein(HURP) is a cellular oncogene that is upregulated in a majority of HCC cases. We highlight here recent findings demonstrating a link between HBx, HURP and anti-apoptosis effects observed in cisplatin-treated HCC cells. We observed that Hep3B cells overexpressing HBx display increased HURP mRNA and protein levels, and show resistance to cisplatin-induced apoptosis. Knockdown of HURP in HBx-expressing cells reverses this effect, and sensitizes cells to cisplatin. The anti-apoptotic effect of HBx requires activation of the p38/MAPK pathway as well as expression of SATB1, survivin and HURP. Furthermore, silencing of HURP using short-hairpin RNA promotes accumulation of p53 and reduces cell proliferation in SK-Hep-1 cells(p53^(+/–)), whereas these effects are not observed in p53-mutant Mahlavu cells. Similarly, HURP silencing does not affect the proliferation of H1299 lung carcinoma cells or Hep3 B HCC cells which lack p53. Silencing of HURP sensitizes SK-Hep-1 cells to cisplatin. While HURP overexpression promotes p53 ubiquitination and degradation by the proteasome, HURP silencing reverses these effects. Inoculation of SK-Hep-1 cancer cells in which HURP has been silenced produces smaller tumors than control in nude mice. Besides, gankyrin, a positive regulator of the E3 ubiquitin ligase MDM2, is upregulated following HURP expression, and silencing of gankyrin reduces HURP-mediated downregulation of p53. In addition, we observed a positive correlation between HURP and gankyrin protein levels in HCC patients(r^2 = 0.778; n = 9). These findings suggest a role for the viral protein HBx and the host protein HURP in preventing p53-mediated apoptosis during cancer progression and establishment of chemoresistance. | Chuck C K Chao | 2016 | World Journal of Hepatology2016，8，25： | 5 |
| 2 | Alkylamides of Echinacea purpurea stimulate alveolar macrophage function in normal rats显示文摘 | VINTI G CHUCK C JAN V | 2002 | International Immunopharmacology2002，2，3： | 1 |
| 3 | Tagging and cloning of petunia flower color gene with the maize transposable element Activator显示文摘 | Chuck G Robbins T Nijjar C | 1993 | Plant Cell1993，5，： | 1 |
| 4 | Recy- cling of woven carbon fiberreinforced polymer composites using supercritical water 显示文摘 | CHASE C K CHANGCHUN Z CHUCK Z | 2012 | Enviromental Technology2012，33，6： | 1 |
| 5 | Corneal sensation after laserin situ keratomileusis显示文摘 | Chuck R S Quiros P A Perez A C | 2000 | Cataract Refract Surg2000，26，： | 1 |
| 6 | Fiber Optic Hydrogen Sensor显示文摘 | Jung Chuck C Saaski Elric W McCrae David A | 1998 | SPIE1998，3489，： | 1 |
| 7 | Tagging and cloning of a petunia flower color gene with the maize transposable element activator 显示文摘 | Chuck G Robbins J Nijjar C | 1993 | Plant Cell1993，5，： | 1 |
| 8 | Visioning: The Future of Civil Engineering显示文摘 | Chuck Pennoni C R | 1992 | Journal of Professional Issues in Engineering Education & Practice1992，118，3： | 1 |
| 9 | Topical steroid and non-teroidal anti-inflammatory drugs inhibit inflammatory cytokirxe expression on the ocular surface in the botulium toxin B-indnced murine dry eve model显示文摘 | Zhu L Zhang C Chuck R S | 2012 | Mol Vis2012，6，18： | 1 |
| 10 | Mapping the domain of troponin T responsible for the activation of actomyosin ATPase activity显示文摘 | Clóvis R N Aurea D S Chuck S F Fernando C R | | J Biol Chem0，275，27： | 1 |
| 11 | An Investigation of the Relationships between Organizational Factors, Business Process Improvement, and ERP Success显示文摘 | CHUCK C H LAW ERIC W T NGAI | 2007 | Benchmarking Bradford2007，14，3： | 1 |
| 12 | Factors affecting the decomposition of biodiesel under simulated engine sump off conditions显示文摘 | Bannister C D Chuck C J Hawley J G | 2010 | Proceedings of the Institution of Mechanical Engineers Part D: Journal of Automobile Engineering2010，224，7： | 1 |
| 13 | An enhanced cooling design in directional solidification for high quality multi-crystalline solar silicon 显示文摘 | LI T F HUANG H C TSAI H W LAIN A CHUCK C LAN C W | 2012 | J Cryst Growth2012，340，1： | 1 |
| 14 | Tagging and cloning of a petunia flower color gene with the maize transposable element Activator显示文摘 | Robbins T Nijjar C Ralston E | 1993 | Plant Cell1993，5，： | 1 |
| 15 | Application of the Colorado River simulation system model to evaluate water shortage conditions in the Central Arizona Project 显示文摘 | Jests R G Chuck C | 2013 | Water Resources Management2013，27，7： | 1 |
| 16 | Fiber optic hydrogen sensor显示文摘 | Chuck C J ung Elric W Saaski | 1998 | Proceedings of SPIE1998，3489，： | 1 |
| 17 | Tagging and cloning of a petunia flower color gene with the maize transposable element activator显示文摘 | Robbins T Nijjar C | 1993 | Plant Cell1993，5，： | 1 |
| 18 | KNAT1 and ERECTA regulate inflorescence architecture in Arabidopsis显示文摘 | DOUGLAS S J CHUCK G DENGLER R E PELECANDA L RIGGS C D | 2002 | Plant Cell2002，14，3： | 1 |
| 19 | Tagging and cloning of petunia flower color gene with the maize transposable element Activator显示文摘 | CHUCK G ROBBINS T NIJJAR C | | 0，，： | 1 |
| 20 | Systematic Risk in the Multinational Corporation显示文摘 | Reeb David Kwok Chuck C Y and Baek Young | 1998 | Journal of International Business Studies1998，，29： | 1 |
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