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| 1 | Mechanical properties and wear and corrosion resistance of electrodeposited Ni–Co/SiC nanocomposite coating显示文摘 | Lei Shi Chufeng Sun Ping Gao Feng Zhou Weimin Liu | 2005 | Applied Surface Science2005，，10： | 2 |
| 2 | Mechanical Prop- erties and Wear and Corrosion Resistance of Elec- trode-posited Ni-Co SiC Nanocomposite Coating显示文摘 | Lei Shi Chufeng Sun Ping Gao | 2006 | Ap- plied Surface Science 20062006，，： | 1 |
| 3 | Experimental Studies of Melanin Associated Antigen and Its Relationship with Sympathetic Ophthalmia and Vogt-Kayanagi-Harada Syndrome显示文摘Purpose: To discuss the relationship of Bovine Melanin-Associated Antigen (BMAA) to Sympathetic Ophthalmia (SO) and Vogt-Kayanagi-Harada (VKH) syndrome.Methods:BMAA was isolated and purified from bovine iris and ciliary body and MTT method was used to measure the peripheral lymphocyte reactions of SO and VKH syndrome patients to BMAA. 15 cases of SO were included in the SO group with 11 males and 4 females. The average age was 37.5, ranging from 23 to 56 years; 15 patients with VKH syndrome were included in the VHK group with 7 males and 8 females. Their average age was 37.2 years, ranging from 24 to 69 years; 20 normal individuals without ocular and systemic autoimmune diseases were included in the control group.These included 9 males and 11 females, aging from 14 to 28 with an average of 23.8 years.Results: The OD values of each group were as follows: SO controls 0.327+0.032; SO+ BMAA 0.490+0.758; SO+PHA 0.5310+0.918; VKH controls 0.328+0.503; VKH+BMAA 0.430 +0.530; VKH +PHA 0.328 +0.484;Normal controls 0.304 +0.267; Normal +BMAA 0.343+0.326; Normal+PHA 0.477+0.598. The average OD values of peripheral lymphocytes to BMAA stimulation in SO patients and normal controls were 0.490 and 0.343 respectively. The difference was statistically significant, P< 0.001; The average OD values of peripheral lymphocytes to BMAA stimulation in SO and VKH syndrome patients were 0.470 and 0.430 respectively. The difference was not statistically significant,P > 0.05.Conclusions:BMAA effectively stimulate the proliferative reaction of peripheral lymphocytes in SO patients and BMAA may act as an antigen and contribute in the pathological process of SO.No difference in proliferative reaction of peripheral lymphocytes was found between SO and VKH syndrome patients after BMAA stimulations and BMAA may be involved in the development of both SO and VKH yndrome. | Xiaofeng Lin, Shaozhen Li, Chufeng Xie, Xiangkun Huang, Zhigang Fan Zhongshan Opthalmic Center, Sun Yat-sen University, Guangzhou 510060, China | 2003 | Eye Science2003，19，3： | 1 |
| 4 | Tribological properties of chemically bonded polyimide films on silicon with polyglyeidyl methaerylate brush as adhesive layer 显示文摘 | Sun Chufeng Zhou Feng Shi Lei | 2006 | Applied Surface Science2006，253，4： | 1 |
| 5 | Mechanical Properties and Wear and Corrosion Resistance of Electrode- posited Ni-Co/SiC Nanocomposite Coating 显示文摘 | Lei Shi Chufeng Sun Ping Gao | 2006 | Applied Surface Science 20062006，，： | 1 |
| 6 | Tribological properties of chemically bonded polyimide films on silicon with polyglyeidyl methacrylate brush as adhesive layer显示文摘 | Zhou Feng Shi Lei | 2006 | Applied Surface Science2006，253，4： | 1 |
| 7 | Nanomaterials with dual immunomodulatory functions for synergistic therapy of breast cancer brain metastases显示文摘A long-standing paucity of effective therapies results in the poor outcomes of triple-negative breast cancer brain metastases.Immunotherapy has made progress in the treatment of tumors,but limited by the non-immunogenicity of tumors and strong immunosuppressive environment,patients with TNBC brain metastases have not yet benefited from immunotherapy.Dual immunoregulatory strategies with enhanced immune activation and reversal of the immunosuppressive microenvironment provide new therapeutic options for patients.Here,we propose a cocktail-like therapeutic strategy of microenvironment regulation-chemotherapy-immune synergistic sensitization and construct reduction-sensitive immune microenvironment regulation nanomaterials(SIL@T).SIL@T modified with targeting peptide penetrates the BBB and is subsequently internalized into metastatic breast cancer cells,releasing silybin and oxaliplatin responsively in the cells.SIL@T preferentially accumulates at the metastatic site and can significantly prolong the survival period of model animals.Mechanistic studies have shown that SIL@T can effectively induce immunogenic cell death of metastatic cells,activate immune responses and increase infiltration of CD8+T cells.Meanwhile,the activation of STAT3 in the metastatic foci is attenuated and the immunosuppressive microenvironment is reversed.This study demonstrates that SIL@T with dual immunomodulatory functions provides a promising immune synergistic therapy strategy for breast cancer brain metastases. | Zhenhao Zhao Chufeng Li Yiwen Zhang Chao Li Yongchao Chu Xuwen Li Peixin Liu Hongyi Chen Yu Wang Boyu Su Qinjun Chen Tao Sun Chen Jiang | 2023 | Bioactive Materials2023，，9： | 0 |
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