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您的检索式：作者名="Chunling Xuan"
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| 1 | Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific subunit vaccines显示文摘There is a great need for new vaccine development against influenza A viruses due to the drawbacks of traditional vaccines that are mainly prepared using embryonated eggs.The main component of the current split influenza A virus vaccine is viral hemagglutinin(HA)which induces a strong antibody-mediated immune response.To develop a modern vaccine against influenza A viruses,the current research has been focused on the universal vaccines targeting viral M2,NP and HA proteins.Crystallographic studies have shown that HA forms a trimer embedded on the viral envelope surface,and each monomer consists of a globular head(HA1)and a“rod-like”stalk region(HA2),the latter being more conserved among different HA subtypes and being the primary target for universal vaccines.In this study,we rationally designed the HA head based on the crystal structure of the 2009-pandemic influenza A(H1N1)virus HA as a model,tested its immunogenicity in mice,solved its crystal structure and further examined its immunological characteristics.The results show that the HA globular head can be easily prepared by in vitro refolding in an E.coli expression system,which maintains its intact structure and allows for the stimulation of a strong immune response.Together with recent reports on some similar HA globular head preparations we conclude that structure-based rational design of the HA globular head can be used for subtype-specific vaccines against influenza viruses. | Chunling Xuan Yi Shi Jianxun Qi Wei Zhang Haixia Xiao George F.Gao | 2011 | Protein & Cell2011，2，12： | 2 |
| 2 | Gluconate 5-dehydrogenase (Ga5DH) participates in Streptococcus suis cell division显示文摘细菌的房间分割严格地在相等的女儿房间的形成被调整。这个过程被一系列空间、时间的管理者管理,并且这块地感兴趣的几个新因素最近被识别了。这里,我们在 zoonotic 病原体链球菌 suis 的房间分割报导 gluconate 5 脱氢酶(Ga5DH ) 的要求。Ga5DH 催化 5-ketogluconate 的可逆减小到 D-gluconate 并且对房间分割的地点局部性。在 S 的 Ga5DH 的删除。suis 与加入子孙的异常 septa 导致了丰满的形态学。重要增加也在房间长度被观察。这些缺点决心是在 S 的 Ga5DH 剥夺的后果。引起 FtsZ delocalization 的 suis。另外,有在 vitro 的 Ga5DH 的 FtsZ 的相互作用被蛋白质相互作用试金证实。这些结果显示 Ga5DH 可以工作在 S 期间阻止宫外的 Z 戒指的形成。suis 房间分割。 | Zhongyu Shi Chunling Xuan Huiming Han Xia Cheng Jundong Wang Youjun Feng Swaminath Srinivass Guangwen Lu George F. Gao | 2014 | Protein & Cell2014，5，10： | 0 |
| 3 | Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific subunit vaccines显示文摘The figure legends for Figure 4 and Figure 5 should be changed as follows:Figure 4.Hemagglutination inhibition(HAI)titers in mice.BALB/c mice were immunized intramuscularly with either 25μg or 50μg of HA57–264.Sera were collected before viral challenge and were assessed against A/California/07/2009.Bars indicate geometric mean titers(GMT).n=8 mice per group. | Chunling Xuan Yi Shi Jianxun Qi Wei Zhang Haixia Xiao George F.Gao | 2012 | Protein & Cell2012，3，2： | 0 |
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