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| 1 | Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver显示文摘Dear Editor,RNA knockdown in vivo carries significant potential for dis-ease modeling and therapies.Despite the emerging approaches of CRISPR/Cas9-mediated permanent knock out of targeted genes,strategies targeting RNA for disruption are advantageous in the treatment of acquired metabolic disorders when permanent modification of genome DNA is not appropriate,and RNA virus infection diseases when pathogenic DNA is not available(such as SARS-Cov-2 and MERS infections). | Bingbing He Wenbo Peng Jia Huang Hang Zhang Yingsi Zhou Xiali Yang Jing Liu Zhijle Li Chunlong Xu Mingxing Xue Hui Yang Pengyu Huang | 2020 | Protein & Cell2020，11，7： | 7 |
| 2 | Research and application on corn crop identification and positioning method based on Machine vision显示文摘Weeds that grow among crops are undesirable plants and have adversely affected crop growth and yield.Therefore,the study explores corn identification and positioning methods based on machine vision.The ultra-green feature algorithm and maximum betweenclass variance method(OTSU)were used to segment maize corn,weeds,and land;the segmentation effect was significant and can meet the following shape feature extraction requirements.Finally,the identification and positioning of corn were achieved by morphological reconstruction and pixel projection histogram method.The experiment reveals that when a weeding robot travels at a speed of 1.6 km/h,the recognition accuracy can reach 94.1%.The technique used in this study is accessible for normal cases and can make a good recognition effect;the accuracy and real-time requirements of robot recognition are improved and reduced the calculation time. | Bingrui Xu Li Chai Chunlong Zhang | 2023 | Information Processing in Agriculture2023，10，1： | 2 |
| 3 | Analysis of the sandwich ul trasonic transducer with two sets of piezoelectric ele ments显示文摘 | Lin Shuyu Xu Chunlong | 2008 | Smart Materials and Structures2008，17，： | 1 |
| 4 | Human 8-cell embryos enable efficient induction of disease-preventive mutations without off-target effect by cytosine base editor显示文摘Approximately 140 million people worldwide are homozygous carriers of APOE4(ε4),a strong genetic risk factor for late onset familial and sporadic Alzheimer’s disease(AD),91%of whom will develop AD at earlier age than heterozygous carriers and noncarriers.Susceptibility to AD could be reduced by targeted editing of APOE4,but a technical basis for controlling the off-target effects of base editors is necessary to develop low-risk personalized gene therapies.Here,we first screened eight cytosine base editor variants at four injection stages(from 1-to 8-cell stage),and found that FNLS-YE1 variant in 8-cell embryos achieved the comparable base conversion rate(up to 100%)with the lowest bystander effects.In particular,80%of AD-susceptibleε4 allele copies were converted to the AD-neutralε3 allele in humanε4-carrying embryos.Stringent control measures combined with targeted deep sequencing,whole genome sequencing,and RNA sequencing showed no DNA or RNA off-target events in FNLS-YE1-treated human embryos or their derived stem cells.Furthermore,base editing with FNLS-YE1 showed no effects on embryo development to the blastocyst stage.Finally,we also demonstrated FNLS-YE1 could introduce known protective variants in human embryos to potentially reduce human susceptivity to systemic lupus erythematosus and familial hypercholesterolemia.Our study therefore suggests that base editing with FNLS-YE1 can efficiently and safely introduce known preventive variants in 8-cell human embryos,a potential approach for reducing human susceptibility to AD or other genetic diseases. | Yinghui Wei Meiling Zhang Jing Hu Yingsi Zhou Mingxing Xue Jianhang Yin Yuanhua Liu Hu Feng Ling Zhou Zhifang Li Dongshuang Wang Zhiguo Zhang Yin Zhou Hongbin Liu Ning Yao Erwei Zuo Jiazhi Hu Yanzhi Du Wen Li Chunlong Xu Hui Yang | 2023 | Protein & Cell2023，14，6： | 0 |
| 5 | Power Minimization for the IRS-Aided SWIPT Secure Communication System with Imperfect Cascaded Channel显示文摘Intelligent reflecting surface(IRS)-assisted simultaneous wireless information and power transfer(SWIPT)is a promising technology for prolonging the lifetime of the users and improving system performance.However,it is challenging to obtain the perfect channel state information(CSI)at the base station(BS)due to the lack of radio frequency(RF)chains at the IRS,which becomes even harder when eavesdroppers(Eves)exist.In this paper,we study the power issues in the IRS-aided SWIPT system under the imperfect CSI of BS-IRS-Eves links.We aim to minimize the transmitting power at the BS by jointly designing transmit beamforming and reflective beamforming with subject to the rate outage probability constraints of the Eves,the energy harvesting constraints of the energy receivers(ERs),and the minimum rate constraints of the information receivers(IRs).We use Bernstein-type inequality to solve the rate outage probability constraints.Afterward,the formulated nonconvex problem can be efficiently tackled by employing alternating optimization(AO)combined with semidefinite relaxation(SDR)and penalty convex-concave procedure(CCP).Numerical results demonstrate the effectiveness of the proposed scheme. | Chunlong He Shuqiong Xu Gongbin Qian Xingquan Li Chiya Zhang | 2023 | Journal of Communications and Information Networks2023，8，2： | 0 |
| 6 | Synthesis, Biological Activity and 3D-QSAR Study of Novel Pyrrolidine-2,4-dione Derivatives Containing N-Substituted Phenylhydrazine Moiety显示文摘 | ZHANG Lizhi REN Zhengjiao LU Aimin ZHAO Zheng XU Wenqin BAO Qianqian DING Weijie YANG Chunlong | 2015 | Chemical Research in Chinese Universities2015，31，2： | 0 |
| 7 | Humoral response to inactivated SARS-CoV-2 vaccines in patients on sirolimus alone显示文摘Dear Editor,Sirolimus,a prototype of mammalian target of rapamycin(m TOR)inhibitor,was approved by the FDA as an immunosuppressant in combination with cyclosporine and corticosteroids for prophylaxis of organ rejection.Reduced immune response of SARS-Co V-2 vaccine has been observed in organ recipients on immunosuppressants containing sirolimus(Mazzola et al.,2022). | Chongsheng Cheng Yani Wang Danjing Hu Wangji Zhou Chunlong Liu Xinlun Tian Hongbing Zhang Ying-Chun Xu Kai-Feng Xu | 2022 | Science China(Life Sciences)2022，65，10： | 0 |
| 8 | Development of RF Cavities at the Department of RF Cavity in 2019显示文摘The cavity design including RF design and multi-physics analysis of the RFQ for the CAFe(Chinese Accelerator Facility for super-heavy Elements)project have been completed by the end of 2019. | Zhang Zhouli Yue Weiming Li Chenxing Li Chunlong Huang Yulu Wang Ruoxu Xu Xianbo Zhang Shengxue Zhang Shenghu He Tao Yang Lei Xing Chaochao Lin Zeqiang | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
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