|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis显示文摘Antibodies against type II collagen(CII)are essential for development of collagen-induced arthritis(CIA),but how and where the B-cell response to CII is initiated is not fully known.We show here that naive DBA/1 mice display naturally reactive IgM and IgG anti-CII producing B cells prior to immunization.The CII-reactive B cells were observed in the spleen and recognized as marginal zone(MZ)B cells.After CII immunization,CII-specific B cells expanded rapidly in the spleen,in contrast to the lymph nodes,with the initial response derived from MZ B cells and later by follicular(FO)B cells.This was evident despite that the MZ B cells were subject to stringent tolerance mechanisms by having a greater Fc gamma receptor IIb expression than the FO B cells.Further,the MZ B cells migrated to the FO areas upon immunization,possibly providing antigen and activating FO T cells and subsequently FO B cells.Thus,around CIA onset increased numbers of IgG anti-CII producing FO B cells was seen in the spleen,which was dominated by IgG2a-and IgG2b-positive cells.These data demonstrate that CII-reactive MZ B cells are present before and expand after CII immunization,suggesting an initiating role of MZ B cells in the development of CIA. | Cecilia Carnrot Kajsa E Prokopec Kristina Rasbo Mikael CI Karlsson Sandra Kleinau | 2011 | Cellular & Molecular Immunology2011，8，4： | 3 |
| 2 | Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells 显示文摘 | Sartor CI Zhou H Kozlowska E | 2001 | Mol Cell Biol2001，21，18： | 1 |
| 3 | Timing of steroid treatment is important for cerebral protection during cardiopulmonary bypass and circulatory arrest:minimal protection of pump prime methylprednisolone显示文摘 | Tchervenkov CI Laliberte E | 2003 | Eur J Cardiothorac Surg2003，24，1： | 1 |
| 4 | The influence of cryotherapy on reduction of swelling, pain and trismus after third-molar extraction: A preliminary study显示文摘 | Laureano Filho JR de Oliveira e Silva ED Batista CI et ai | 2005 | J Am Dent Assoc2005，136，6： | 1 |
| 5 | Sympathetic nervous system activity is associated with obesity-induced subclinical organ damage in young adults显示文摘 | Lambert E Sari CI Dawood T | 2010 | Hypertension2010，56，3： | 1 |
| 6 | Motor and cognitive recovery induced by bone marrow stem cells grafted to striatum and hippocampus of impaired aged rats: functional and therapeutic considerations显示文摘 | Fernandez CI Alberti E Mendoza Y | 2004 | Ann N Y Acad Sci2004，1019，： | 1 |
| 7 | Management of cancer pain : ESMO Clinical Practice Guidelines 显示文摘 | Ripamonti CI Santini D Maranzano E | 2012 | Ann Oncol2012，23，7： | 1 |
| 8 | Outcome after silicone oil removal and simultaneous 360 degrees endolaser treatment 显示文摘 | Falkner- Radler CI Smretschnig E Graf A | 2011 | Acta Ophthalmol2011，89，1： | 1 |
| 9 | Management of cancer pain: ESMO Clinical Practice Guidelines显示文摘 | Ripamonti CI Santini D Maranzano E | 2012 | Annals of Oncology2012，23，7： | 1 |
| 10 | Factors influencing the onset of diahetes mellitus after kidney transplantation:a single French center experience显示文摘 | Marin M Renoult E Bondor CI | | 0，，： | 1 |
| 11 | MP Bcl-3 is an interleukin-1-responsive gene in chondrocytes and synovial fibroblasts that activates transcription of the matrix metalloproteinase 1 gene显示文摘 | Elliott SF Coon CI Hays E | 2002 | Arthritis Rheum2002，46，12： | 1 |
| 12 | Correlation of reduction in mrp-1/cd9 and kai1/cd82 expression with recurrences in breast cancer patients显示文摘 | Huang CI Kohno N Ogawa E | 1998 | Am J Pathol1998，153，： | 1 |
| 13 | Motor and cognitive recovery induced by bone marrow stem cells grafted to striatum and hippocampus of impaired aged rats: functional and therapeutic considerations显示文摘 | Fernandez CI Alberti E Mendoza Y | 2004 | Ann N Y Acad Sci2004，1019，： | 1 |
| 14 | Inhibition of FLT3-mediated transformation by use of a tyrosine kinase inhibitor显示文摘 | Tse KF Novelli E Civin CI | 2001 | Leukemia2001，15，7： | 1 |
| 15 | Deformation of network connectivity in the inferior olive of connexin 36-deficient mice is compensated by morphological and electrophysiological changes at the single neuron level显示文摘 | De Zeeuw CI Chorev E Devor A | | 0，，11： | 1 |
| 16 | Associations between the built environment, total, recreational, and transit-related physical activity 显示文摘 | De Sa E Ardern CI | 2014 | BMC Public Health2014，14，： | 1 |
| 17 | Spinal astrocytes in pain processing:non- neuronal cells as therapeutic targets 显示文摘 | Svensson CI Brodin E | 2010 | Mol Interv2010，10，1： | 1 |
| 18 | Factors associated with active smoking,quitting,and secondhand smoke exposure among pregnant women in Greece显示文摘 | VARDAVAS CI PATELAROU E CHATZI L | | 0，，05： | 1 |
| 19 | Dyslipidemia is associated with sympathetic nervous activation and impaired endothelial function in young females显示文摘 | Lambert E Straznicky N Sari CI | 2013 | Am J Hypertens2013，26，2： | 1 |
| 20 | Expression of heme oxygenase-1 in human livers before transplantation correlates with graft Injury and function after transplantation 显示文摘 | Geuken E Buis CI Vsser DS | 2005 | Am J Transplant2005，5，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员