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| 1 | Conventional therapy for moderate to severe inflammatory bowel disease: A systematic literature review显示文摘BACKGROUND Despite the advent of biological drugs, conventional therapy continues to be used in moderate to severe inflammatory bowel disease(MS-IBD). This study hypothesized that as a standard of treatment and the primary alternative to biologics, conventional therapy should present robust effectiveness results in IBD outcomes.AIM To investigate the effectiveness of conventional therapy for MS-IBD.METHODS A systematic review with no time limit was conducted in July 2017 through the Cochrane Collaboration, MEDLINE, and LILACS databases. The inclusion criteria encompassed meta-analyses, systematic reviews, randomized clinical trials, observational and case-control studies concerning conventional therapy in adult patients with MS-IBD, including Crohn's disease(CD) and ulcerative colitis(UC). Corticosteroids(prednisone, hydrocortisone, budesonide, prednisolone,dexamethasone), 5-aminosalicylic acid(5-ASA) derivatives(mesalazine and sulfasalazine) and immunosuppressants [azathioprine(AZA), methotrexate(MTX), mycophenolate, cyclosporine, tacrolimus, 6-mercaptopurine(6-MP)] were considered conventional therapy. The exclusion criteria were sample size below50; narrative reviews; specific subpopulations(e.g., pregnant women,comorbidities); studies on postoperative IBD; and languages other than English,Spanish, French or Portuguese. The primary outcome measures were clinical remission(induction or maintenance), clinical response and mucosal healing. As secondary outcomes, fecal calprotectin, hospitalization, death, and surgeries were analyzed. The quality of the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation criteria.RESULTS The search strategy identified 1995 citations, of which 27 were considered eligible(7 meta-analyses, 20 individual studies). For induction of clinical remission, four meta-analyses were selected(AZA and 6-MP showed no advantage over placebo,MTX or 5-ASA in CD; MTX showed no statistically significant difference versus placebo, 6-MP, or 5-ASA in UC; tacrolimus was superior to placebo for UC in two meta-analyses). Only one meta-analysis evaluated clinical remission maintenance, showing no statistically significant difference between MTX and placebo, 5-ASA, or 6-MP in UC. AZA and 6-MP had no advantage over placebo in induction of clinical response in CD. Three meta-analyses showed the superiority of tacrolimus vs placebo for induction of clinical response in UC. The clinical response rates for cyclosporine were 41.7% in randomized controlled trials(RCTs) and 55.4% in non-RCTs for UC. For induction of mucosal healing,one meta-analysis showed a favorable rate with tacrolimus versus placebo for UC. For secondary outcomes, no meta-analyses specifically evaluated fecal calprotectin, hospitalization or death. Two meta-analyses were retrieved evaluating colectomy rates for tacrolimus and cyclosporine in UC. Most of the twenty individual studies retrieved contained a low or very low quality of evidence.CONCLUSION High-quality evidence assessing conventional therapy in MS-IBD treatment is scarce, especially for remission maintenance, mucosal healing and fecal calprotectin. | Adérson Omar Mourao Cintra Damiao Matheus Freitas Cardoso de Azevedo Alexandre de Sousa Carlos Marcela Yumi Wada Taciana Valéria Marcolino Silva Flávio de Castro Feitosa | 2019 | World Journal of Gastroenterology2019，25，9： | 13 |
| 2 | Tibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice显示文摘Aging is a key risk factor for cognitive decline and age-related neurodegenerative disorders. Also, an age-related decrease in sex steroid hormones may have a negative impact on the formation of neurofibrillary tangles(NFTs); these hormones can regulate Tau phosphorylation and the principal kinase GSK3β involved in this process. Hormone replacement therapy decreases NFTs, but it increases the risk of some types of cancer. However, other synthetic hormones such as tibolone(TIB) have been used for hormone replacement therapy. The aim of this work was to evaluate the long-term effects of TIB(0.01 mg/kg and 1 mg/kg, intragastrically for 12 weeks) on the content of total and hyperphosphorylated Tau(PHF-1) proteins and the regulation of GSK3β/Akt/PI3 K pathway and CDK5/p35/p25 complexes in the hippocampus of aged male mice. We observed that the content of PHF-1 decreased with TIB administration. In contrast, no changes were observed in the active form of GSK3β or PI3 K. TIB decreased the expression of the total and phosphorylated form of Akt while increased that of p110 and p85. The content of CDK5 was differentially modified with TIB: it was increased at low doses and decreased at high doses. When we analyzed the content of CDK5 activators, an increase was found on p35; however, the content of p25 decreased with administration of low dose of TIB. Our results suggest a possible mechanism of action of TIB in the hippocampus of aged male mice. Through the regulation of Tau and GSK3β/Akt/PI3 K pathway, and CDK5/p35/p25 complexes, TIB may modulate neuronal plasticity and regulate learning and memory processes. | Teresa Neri-Gomez Judith Espinosa-Raya Sofia Diaz Cintra Julia Segura-Uribe Sandra Orozco-Suarez Juan Manuel Gallardo Christian Guerra-Araiza | 2017 | Neural Regeneration Research2017，12，4： | 12 |
| 3 | How to manage inflammatory bowel disease during the COVID-19 pandemic:A guide for the practicing clinician显示文摘Managing inflammatory bowel disease(IBD)during the coronavirus disease 2019(COVID-19)pandemic has been a challenge faced by clinicians and their patients,especially concerning whether to proceed with biologics and immunosuppressive agents in the background of a global outbreak of a highly contagious new coronavirus(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2).The knowledge about the impact of this virus on patients with IBD,although it is still scarce,is rapidly evolving.In particular,concerns surrounding medications’impact for IBD on the risk of acquiring SARS-CoV-2 infection or developing COVID-19,and potentially exacerbate viral replication and the COVID-19 course,are a current thinking of both practicing clinicians and providers caring for patients with IBD.Managing patients with IBD infected with SARS-CoV-2 depends on both the clinical activity of the IBD and the occasional development and severity of COVID-19.In this review,we summarize the current data regarding gastrointestinal involvement by SARS-CoV-2 and pharmacologic and surgical management for IBD concerning this infection,and the COVID-19 impact on both the patient's psychological functioning and endoscopy services,and we concisely summarize the telemedicine roles during the COVID-19 pandemic. | Júlio Maria Fonseca Chebli Natália Sousa Freitas Queiroz Adérson Omar Mourão Cintra Damião Liliana Andrade Chebli Márcia Henriques de Magalhães Costa Rogério Serafim Parra | 2021 | World Journal of Gastroenterology2021，27，11： | 2 |
| 4 | First Report of a Closterovirus-Like Particle Associated with Pineapple Plants显示文摘 | Eduviges G B Mayra Cintra Justo Gonzalez | 1998 | Plant Disease1998，82，2： | 1 |
| 5 | Hypothesis Testing in Speckled Data with Stochastic Distances显示文摘 | NASCIMENTO A D C CINTRA R J FRERY A C | 2010 | IEEE Transactions on Geoscience and Remote Sensing2010，48，1： | 1 |
| 6 | Orthothotropic closure approximations for flow-induced fiber orientation显示文摘 | Cintra J S Tucker C L | 1995 | J Rheol1995，39，6： | 1 |
| 7 | Algorithms for two-di- mensional cutting stock and strip packing problems using dynamic pro- gramming and column generation 显示文摘 | Cintra G F Miyazawa F K Wakabayashi Y | 2008 | European Journal of Operational Research2008，191，1： | 1 |
| 8 | Colocalization of fos and glucocorticoid receptor immunoreactivities is present only in a very restricted population of dorsal horn neurons of the rat spinal cord after nociceptive stimulation显示文摘 | Cintra A Molander C Fuxe K | 1993 | Brain Res1993，632，1： | 1 |
| 9 | Unsaturated fatty acids revert diet-induced hypothalamic inflammation in obesity 显示文摘 | Cintra D E Ropelle E R Moraes J C | 2012 | PLoS One2012，7，30： | 1 |
| 10 | Quality of life and measure of Disease in elderly people with end-stage renal disease显示文摘 | Souza F F Cintra F A Gallani M C | 2005 | Rev Bras Enferm2005，58，5： | 1 |
| 11 | Wavelet analysis in a canine model of gastric electrical uncoupling显示文摘 | Cintra RJS Tchervensky Ⅳ Dimitrov VS | 2004 | Physiol Meas2004，25，6： | 1 |
| 12 | Antioxidant activity of the microalga Spirulina maxima显示文摘 | Miranda M S Cintra R G Barros S B M | 1998 | Braz J Med Biol Res1998，31，8： | 1 |
| 13 | Saturated faTTy acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus:implications for the pathogenesis of obesity显示文摘 | Milanski M Degasperi G Coope A Morari J Denis R Cintra D E Tsukumo D M Anhe G | | 0，，02： | 1 |
| 14 | IL-6 and IL-10 an- ti-inflammatory activity links exercise to hypothalamic insulin and leptin sensitivity through IKKβ and ER stress inhibition 显示文摘 | Ropelle E R Flores M B Cintra D E | 2010 | PLoS Biol2010，8，10： | 1 |
| 15 | Vasopressin serum levels in patients with severe brain lesions and in brain-dead patients显示文摘 | Cintra Ede A Maciel JA Jr Arau jo S | 2004 | Arq Neuropsiquiatr2004，62，2： | 1 |
| 16 | A Row-parallel88 2-D DCT architecture using algebraic integer-based exact computation显示文摘 | Madanayake A Cintra RJ Onen D | 2012 | IEEE Trans on Circuits and System for Video Technology2012，22，6： | 1 |
| 17 | Ectodermal dysplasia with acanthosis nigricans (Lelis syndrome)显示文摘 | Steiner CE Cintra ML Marques-de-Faria AP | 2002 | Am J Med Genet2002，113，4： | 1 |
| 18 | Acute exercise re- verses aged -induced impairments in insulin signaling in rodent skeletal muscle显示文摘 | Pauli J R Ropelle E R Cintra D E | 2010 | Mech Ageing Dev2010，131，5： | 1 |
| 19 | pancreatic beta cells are impor- tant targets for the diabetogenic effects of glucocorticoids显示文摘 | Delaunay F Khan A Cintra A | 1997 | J Clin Invest1997，100，8： | 1 |
| 20 | On the role of glucocorticoid receptors in brain plasticity显示文摘 | Fuxe K Kiaz R Cintra A | 1996 | Cell Mol Neurobiol1996，16，： | 1 |
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