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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Speed, Size, and Edge-rate Information for the Detection of Collision Events 显示文摘 | ANDERSEN G J CISNEROS J ATCHLEY P | 1999 | Journal of Experimental Psychology: Human Perception and Performance1999，25，1： | 1 |
| 3 | Matrix metalloproteinasesinhibition attenuates tobacco smoke - induced emphysema in guinea pigs 显示文摘 | Selman M Cisneros - Lira J Gaxiola M Ramirez R Kudlacz E M Mitchell P G Pardo A | 2003 | Chest2003，123，5： | 1 |
| 4 | Chronic ethanol or glucose consumption alter TRH content and pyroglutamyl aminopeptidase Ⅱ activity in rat limbic regions 显示文摘 | de Gortari P Cisneros M Joseph-Bravo P | 2005 | Regul Pept2005，127，13： | 1 |
| 5 | Influ- ence of rainfall spatial variability on flood prediction 显示文摘 | ARNAUD P BOUVIER C CISNEROS L | 2002 | Journal of Hydrology2002，260，1234： | 1 |
| 6 | Retinitis pigmentosa: cone photoreceptors starving to death显示文摘 | Bovolenta P Cisneros E | 2009 | Nat Neurosci2009，12，1： | 1 |
| 7 | Influence of rainfall spatial variability on flood prediction显示文摘 | Amaud P Bouvier C Cisneros | | 0，，： | 1 |
| 8 | Adalimumab-induced interstitial pneumonia in a patient with Crohn's disease显示文摘There are several reports of anti-tumor necrosis factor(TNF)-induced lung disease,especially in patients with rheumatologic diseases.Adalimumab is an antiTNF drug used to induce and maintain remission in patients with immune-mediated diseases,such as Crohn’s disease.Although pulmonary disorders could be an extra-intestinal manifestation of inflammatory bowel disease,biologic therapy could also be a cause of lung injury.Only few cases of adalimumab-induced lung toxicity have been reported,and the majority of them were in patients with rheumatologic diseases.Lung injury secondary to anti-TNF therapy should,after ruling out other etiologies,be considered in patients who have a temporal association between the onset of respiratory symptoms and the exposure to these drugs.A compatible pattern in the biopsy and the clinical improvement after discontinuation of the anti-TNF drug would strongly support the diagnosis. | María José Casanova María Chaparro Claudia Valenzuela Carolina Cisneros Javier P Gisbert | 2015 | World Journal of Gastroenterology2015，21，7： | 1 |
| 9 | A ki- netic study of the aceeleration effect of substituted benzyl alcohols on the cationic: photopolymerization rate of epoxi- dized natural oils 显示文摘 | ORTIZ R A LOPEZ D P CISNEROS M D G | 2005 | Polymer2005，46，5： | 1 |
| 10 | Speed, Size, and Edge - Rate Information for the Detection of Collision Events 显示文摘 | Anderson G J Cisneros J Atchley P | 1999 | Journal of Experimental Psychology: Human Perception and Performance1999，25，1： | 1 |
| 11 | Prevalence of premature urinary luteinizing hormone surges in women with regular menstrual cycles and its effect on implantation of frozen-thawed embryos显示文摘 | Krotz S McKenzie LJ Cisneros P | 2005 | Fertil Steril2005，83，6： | 1 |
| 12 | Influence of Rainfall Spatial Variability on Flood Prediction 显示文摘 | Arnaud P Bouvier C Cisneros L | 2002 | Journal of Hydrology2002，260，14： | 1 |
| 13 | Influence for rainfall spatial variability on flood prediction显示文摘 | Arnaud P Bouvier C Cisneros L | 2002 | Journal of Hydrology2002，260，14： | 1 |
| 14 | Experimental assessment of the sprinkler application rate for steep sloping fields 显示文摘 | Cisneros Espinosa F E Torres P Feyen J | 2007 | Journal of Irrigation and Drainage Engineering2007，133，3： | 1 |
| 15 | Antiinfective effect of poly -β - ( 1,6) - glucotriosyl -β- ( 1,3 ) - glucopyranose glucan in vivo 显示文摘 | Onderdonk A B Cisneros R L Hinkson P | 1992 | Infect Immun1992，60，： | 1 |
| 16 | Voltammetric determination of trace mercury at a son gel-carbon electrode modified with poly-3-methylthiophene显示文摘 | Zejli H Sharrock P Hidalgo-Hidalgo de Cisneros J L | 2005 | Talanta2005，68，： | 1 |
| 17 | Influence of rainfall spatial variability on flood prediction显示文摘 | ARNAUD P BOUVIER C CISNEROS L | 2002 | Journal of Hydrology2002，260，： | 1 |
| 18 | Canine Retraction:a Comparison of Two Preadjusted Bracket Systems显示文摘 | Lotzof L P Fine H A Cisneros G J | 1996 | Am J Orthod Dentofacial Orthop1996，110，3： | 1 |
| 19 | Prevalence of pre- mature urinary luteinizing hormone surges in women with regular menstrual cycles and its effect on implantation of frozen-thawed embryos 显示文摘 | Krotz S Mckenzie LJ Cisneros P | 2005 | Fertil Steril2005，83，6： | 1 |
| 20 | Influence of rainfall spatial variability on flood prediction 显示文摘 | Arnaud P Bouvier C Cisneros L Dominguez R | 2002 | Journal of Hydrology2002，260，14： | 1 |
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