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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | High-intensity focused ultrasound ablation as a bridging therapy for hepatocellular carcinoma patients awaiting liver transplantation显示文摘The scarcity of liver grafts in Asia leads to a significant dropout of patients from liver transplant waiting lists, particularly patients with hepatocellular carcinoma and a low model for end-stage liver disease score. In order to reduce dropping out, different bridging therapies are employed. We report the use of high-intensity focused ultrasound ablation as a bridging therapy for a patient with hepatocellular carcinoma of stage two and an extremely low platelet count (20×10 9 /L). The ablation was successful. Blood tests showed that his liver function was similar before and after the treatment. No adhesion was encountered in the liver transplantation performed six months later. | Tan To Cheung Kenneth SH Chok Regina CL Lo William W Sharr See Ching Chan Ronnie TP Poon Sheung Tat Fan Chung Mau Lo | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 3 |
| 3 | Glucose metabolism is required for oxidized LDL-induced macrophage survival: role of PI3K and Bcl-2 family proteins显示文摘 | Elsegood CL Chang M Jessup W | 2009 | Arterioscler Thromb Vasc Bi- ol2009，29，9： | 1 |
| 4 | Characteristics of calcaneus quantitative ultrasound normative data in Chinese mainland men and women显示文摘 | Liu W Xu CL Zhu ZQ | 2006 | Osteoporos Int2006，17，8： | 1 |
| 5 | Differential effects of autologous peripheral nerve grafts to the corpus striatum of adult rats on the regeneration ofaxons of striatal and nigral neurons and on the expression of GAP43 and the cell adhesion molecules N-CAM and Ll显示文摘 | W oolhead CL Zhang Y Lieberman AR | 1998 | J Comp Neurol1998，391，2： | 1 |
| 6 | Unmasking the dynamic interplay between intestinal P- glycoprotein and CYP3A4显示文摘 | Cummins CL Jacobsen W Benet LZ | 2002 | J Pharmacol Exp Ther2002，，： | 1 |
| 7 | Inhibitors of HER2/neu(erbB-2) signal transduction显示文摘 | Arteaga CL Chinratanalab W Carter MB | 2001 | Semin Oncol2001，28，618： | 1 |
| 8 | Atopy,serum IgE,and interleukin-13 in steroid-responsive nephritic syndrome显示文摘 | Cheung W Wei CL Seah CC | 2004 | Pediatr Nephrol2004，19，6： | 1 |
| 9 | Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects 显示文摘 | Milunsky A Jick H Jick SS Bruell CL MacLaughlin DS Roth- man KJ WiUett W | 1990 | JAMA1990，263，20： | 1 |
| 10 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 11 | Nutrition and physical activity guidelines for cancer survivors显示文摘 | Rock CL Doyle C Demark-Wahnefried W Meyerhardt J Courneya KS Schwartz AL | | 0，，： | 1 |
| 12 | 查看详情显示文摘 | Chen X B Liao H B Zhang C L Yu CL Pan W Hu L L Wu Z L | | 0，，： | 1 |
| 13 | The relationship between moderate-to-vigorous intensity physical activity and insulin resistance,insulin-like growth factor(IGF-1)-system 1,leptin and weight change in healthy women during pregnancy and after delivery显示文摘 | van der Wijden CL Delemarre-Van DWH van Mechelen W | 2015 | Clin Endocrinol(Oxf)2015，82，1： | 1 |
| 14 | Ameliorative effect of berberine on renal damage in rats with diabetes induced by highfat diet and streptozotocin显示文摘 | Wu D Wen W Qi CL Zhao RX LüJH Zhong CY | 2012 | Phytomedicine2012，19，89： | 1 |
| 15 | Two-year results from the globe trial in patients with hepatitis:greater clinical and antiviral efficacy for telbivudine(LdT) vs lamivudine显示文摘 | Lai CL Gane E Hsu C W | 2006 | Hepatology2006，44，41： | 1 |
| 16 | Thermosensitive TRPV chan- nel subunits coassemble into heteromeric channels with intermediate conductance and gating properties 显示文摘 | Cheng W rang F Takanishi CL | 2007 | J Gen Physiol2007，129，3： | 1 |
| 17 | The effect of a counselling intervention on weight changes during and after pregnancy:a randomised trial显示文摘 | Althuizen E van der Wijden CL van Mechelen W | 2013 | BJOG2013，120，1： | 1 |
| 18 | Sorption of a branched nonylphenol and perfluorooctanoic acid on Yangtze river sediments and their model components显示文摘 | Li CL Ji R Schaffer A Sequaris JM Amelung W Vereeckena H Klumpp E | 2012 | Journal of Environmental Monitor2012，14，10： | 1 |
| 19 | Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice 显示文摘 | Aimin X Michael CL Kok W C | 2005 | Proc Natl Acad Sci USA2005，102，17： | 1 |
| 20 | Impact of Aspirin Therapy in Cancer Patients With Thrombocytopenia and Acute Coronary Syn- dromes显示文摘 | Sarkiss MS Yusuf W Warneke CL | 2007 | Cancer2007，109，： | 1 |
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