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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | The effect of recombinant human erythropoietin on neurovasculature repair after focal ischemic stroke in neonatal rats 显示文摘 | Keoqh CL Yu SP Wei L | 2007 | J Pharmacol Exp Ther2007，322，： | 1 |
| 3 | An efficient and convenient reaction protocol to organoimido derivatives of polyoxometalates 显示文摘 | WEI Y XU B BARNES CL | 2001 | J Am Chem Soc2001，1，23： | 1 |
| 4 | Early prediction of response to intravenpus iron supplementation by reticulocyte haemoglobin content and high-fluorescence reticulocyte count in haemodialysis patients 显示文摘 | Chuang CL Liu RS Wei YH | 2003 | Nephrol Dial Transplant2003，18，2： | 1 |
| 5 | Overexpression of interleukin13 induces minimal-change-like nephropathy in rats显示文摘 | Lai KW Wei CL Tan LK | 2007 | J Am Soc Nephrol2007，18，： | 1 |
| 6 | Atopy,serum IgE,and interleukin-13 in steroid-responsive nephritic syndrome显示文摘 | Cheung W Wei CL Seah CC | 2004 | Pediatr Nephrol2004，19，6： | 1 |
| 7 | Modification of kidney barrier function by the urokinase receptor显示文摘 | Wei CL Moller CC Altintas MM | 2008 | Nat Med2008，14，1： | 1 |
| 8 | A global map of p53 transcription-factor binding sites in the human genome显示文摘 | Wu Q Vega VB | 2006 | Cell2006，124，1： | 1 |
| 9 | Resident intruder paradigm-induced aggression relieves depressive-like behaviors in male rats subjected to chronic mild stress显示文摘 | Wei S Ji XW Wu CL | 2014 | Med Sci Monit2014，，20： | 1 |
| 10 | Decreased of microRNA -199bincreases protein levels of SET (protein phosphatase 2A inhibitor) in human choriocarcinoma显示文摘 | Qw A Tsai CL Wei PC a aI | 2010 | Cancer Leu2010，291，1： | 1 |
| 11 | The effect of recombinant human erythropoie- tin on neurovasculature repair after focal ischemic stroke in neonatal rats 显示文摘 | Keogh CL Yu SP Wei L | 2007 | J Pharmacol Exp Ther2007，322，： | 1 |
| 12 | Laparoscopic versus open appendectomy for acute appendicitis: a meta-analysis显示文摘 | Wei B Qi CL Chen TF | 2011 | Surg Endosc2011，25，4： | 1 |
| 13 | A Preliminary Cost Curve Assessment of Carbon Dioxide Capture and Storage Potential in China 显示文摘 | R T Dahowski X Li CL Davidson N Wei JJ Dooley RH Gentile | 2009 | Energy Procedia2009，，1： | 1 |
| 14 | Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection显示文摘 | Ruan YJ Wei CL Ee LA | 2003 | Lancet2003，361，9371： | 1 |
| 15 | Trace elements and leukocythemia显示文摘 | Zlaou CL Li YJ Wei AY | 2002 | Trace elements and health research2002，19，2： | 1 |
| 16 | Endothelial determinants of dendritic cell adhesion and migration: new implications for vascular diseases显示文摘 | Weis M Schlichting CL Engleman EG | 2002 | Arterioscler Thromb Vasc Biol2002，22，11： | 1 |
| 17 | Comparative full length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection显示文摘 | Ruan Y J Wei CL Ee AL | 2003 | Lancet2003，361，9371： | 1 |
| 18 | Endothelial determinants of dendritic cell adhesion and migration: new implications for vascular diseases 显示文摘 | Weis M Schlichting CL Fagleman EG Cooke JP | 2002 | Arterioscler Thromb Vasc Biol2002，22，11： | 1 |
| 19 | Apoferritin-camouflagedpt nanoparticles:Surface effects on cellular uptake andcytotoxicity显示文摘 | Liu XY Wei W Wang CL | 2011 | Journal of Materials Chemistry2011，21，20： | 1 |
| 20 | Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection显示文摘 | Ruan YJ Wei CL Ee AL | 2003 | Lancet2003，361，9371： | 1 |
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