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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Cytoreductive surgery and intrap- eritoenal chemohyperthermia for recurrent peritoneal carcionomatosis from ovarian Eancer显示文摘 | Zanon C Clara R Chiappino I | 2004 | World J Surg2004，28，： | 1 |
| 3 | Combined regional and systemic chemotherapy by a mini-invasive approach for the treatment of colorectal liver metastases显示文摘 | Zanon C Grosso M Clara R | 2001 | Am J Clin Oncol2001，24，4： | 1 |
| 4 | Cytoreductive surgery and intraperitoneal chemohyperthermia for recurrent peritoneal carcinomatosis from ovarian 显示文摘 | Zanon C Clara R Chiappino I | 2004 | Cancer World J Surg2004，28，： | 1 |
| 5 | Cytoreductive surgery and intraperitoneal chemohyperthermia for recurrent peritoneal carcinomatosis from ovarian cancer显示文摘 | Zanon C Clara R Chiappino I | 2004 | World J Surg2004，28，： | 1 |
| 6 | An introduction to RFID technology显示文摘 | WANT R RES I SANTA CLARA C A | 2006 | 1EEE Pervasive Computing2006，5，1： | 1 |
| 7 | Chemobypertbermia for advanced abdominal malignancies: a new procedure with closed abdomen and previously perfonmed auastomosis 显示文摘 | Zanaon C clara R Bortolini M | 2001 | int J Hyperthelnia2001，17，5： | 1 |
| 8 | Cytoreductive surgery and intraperitoneal chemohyperthermia for recurrent peritoneal carci- nomatosis from ovarian cancer 显示文摘 | Zanon C Clara R Chirappino I | 2004 | World Surgery2004，28，： | 1 |
| 9 | Molecular analysis of the PROP1 and HESX1 genes in patients with septo-optic dysplasia and/or pituitary hormone deficiency显示文摘 | Cruz J B Nunes V S Clara S A Perone D Kopp P Nogueira C R | | 0，，： | 1 |
| 10 | Differential diagno- sis of dog hookworms based on PCR-RFLP from the ITS region of their rDNA 显示文摘 | Clara E M Miranda R C Santos H A | 2006 | Vet Parasitol2006，140，34： | 1 |
| 11 | Particle swarm optimization with two swarms for the discrete (rip)-centroid problem显示文摘 | Clara C R Jos 6 A M P Dolores R S | 2012 | Leeture Notes in Computer Science2012，6927，： | 1 |
| 12 | Cytoreductive surgery and intraperitoneal chemohyperthermia for recurrent peritoneal carcinomatosis from ovarian cancer显示文摘 | Zanon C Clara R Chiappino I | 2004 | World J Surg2004，28，10： | 1 |
| 13 | Lactic acid bacteria iso- lated from young calves-Characterization and potential as probiotics 显示文摘 | Natalia C M Clara S R Maria C O | 2012 | Research in Veterinary Science2012，92，2： | 1 |
| 14 | Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010:a systematic analysis显示文摘 | Nair H Simoes E A Rudan I Gessner B D AzzizBaumgartner E Zhang J S Feikin D R Mackenzie G A Moisi J C Roca A Baggett H C Zaman S M SingletonR J Lucero M G Chandran A Gentile A Cohen C Krishnan A Bhutta Z A Arguedas A Clara A W Andrade A L Ope M Ruvinsky R O Hortal M McCracken J P Madhi S A Bruce N Qazi S A Morris S S El Arifeen S Weber M W Scott J A Brooks W A Breiman R F Campbell H | 2013 | Lancet2013，381，9875： | 1 |
| 15 | Watermarking algorithm based on the DWT 显示文摘 | Victor H G Clara C R Mariko N M | 2006 | IEEE Latin America Transactions2006，4，4： | 1 |
| 16 | Cytoreductive surgery and intraperitoneal chemohyperthermia for recurrent peritoneal carcinomatosis from ovarian cancer 显示文摘 | Zanon C Clara R ChiappinoI | 2004 | World J Surg2004，28，10： | 1 |
| 17 | Chemohyperthermia for advanced abdominal malignancies: a new procedure with closed abdomen and previously performed anastomosis显示文摘 | Zanon C Clara R Bortolini M | 2001 | Int J Hyperthermia2001，17，5： | 1 |
| 18 | Cytoreductive surgery and intraperitoneal chemohyperthermia for recurrent peritoneal carcinomatosis from ovarian cancer 显示文摘 | Zanon C Clara R Chiappino I | 2004 | World J Surg2004，28，10： | 1 |
| 19 | Cytoreductive surgery and intraperitoneal chemohyperthermia for recurrent peritoneal carcinomatosis from ovarian dancer 显示文摘 | Zanon C Clara R Chiappino i | 2006 | World surg2006，28，10： | 1 |
| 20 | Cytoreductive surgery and intraperitoneal chemohyperthermia for recurrent peritoneal carcinomatosis from ovarian cancer显示文摘 | Zanon C Clara R Chiappino I | 2004 | World J Surg2004，28，10： | 1 |
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