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| 1 | Management of Helicobacter pylori infection in Latin America: A Delphi technique-based consensus显示文摘AIM: To optimize diagnosis and treatment guidelines for this geographic region, a panel of gastroenterologists, epidemiologists, and basic scientists carried out a structured evaluation of available literature.METHODS: Relevant questions were distributed among the experts, who generated draft statements for consideration by the entire panel. A modified three-round Delphi technique method was used to reach consensus. Critical input was also obtained from representatives of the concerned medical community. The quality of the evidence and level of recommendation supporting each statement was graded according to United States Preventive Services Task Force criteria.RESULTS: A group of ten experts was established. The survey included 15 open-ended questions that were distributed among the experts, who assessed the articles associated with each question. The levels of agreement achieved by the panel were 50% in the first round, 73.3% in the second round and 100% in the third round. Main consensus recommendations included:(1) when available, urea breath and stool antigen test(HpSA) should be used for non-invasive diagnosis;(2) detect and eradicate Helicobacter pylori(H. pylori) in all gastroscopy patients to decrease risk of peptic ulcer disease, prevent o retard progression in patients with preneoplastic lesions, and to prevent recurrence in patients treated for gastric cancer;(3) further investigate implementation issues and health outcomes of H. pylorieradication for primary prevention of gastric cancer in high-risk populations;(4) prescribe standard 14-d triple therapy or sequential therapy for first-line treatment;(5) routinely assess eradication success post-treatment in clinical settings; and(6) select second- and third-line therapies according to antibiotic susceptibility testing.CONCLUSION: These achievable steps toward better region-specific management can be expected to improve clinical health outcomes. | Antonio Rollan Juan Pablo Arab M Constanza Camargo Roberto Candia Paul Harris Catterina Ferreccio Charles S Rabkin Juan Cristóbal Gana Pablo Cortés Rolando Herrero Luisa Durán Apolinaria García Claudio Toledo Alberto Espino Nicole Lustig Alberto Sarfatis Catalina Figueroa Javier Torres Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，31： | 2 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Highly sulfated dermatan sulfates from ascidiand: Structure versus anticoagulant activity of these glycosaminoglycans显示文摘 | Pavao Mauro S G Aiekko Karin R M Werneck Claudio C | 1998 | J Biol Chem1998，273，27： | 1 |
| 4 | Coutinho critical assessment of the formation of ionic-liquid-based aqueous two-phase systems in acidic media显示文摘 | CLAUDIO A F M FERREIRA A M SHAHRIARI S FREIRE M G JOAO A P | 2011 | J Phys Chem B2011，115，11： | 1 |
| 5 | Solving advanced network reliability problems by means of cellular automata and Monte Carlo sampling显示文摘 | Claudio M ROCCO S Enrico ZIO | 2005 | Reliability Engineering and System Safety2005，89，2： | 1 |
| 6 | Impact of breast MRI on surgical treatment,axillary approach,and systemic therapy for breast cancer显示文摘 | CLAUDIA S CLAUDIO K SUZAN M | 2008 | Breast J2008，14，3： | 1 |
| 7 | Effects of annealing on the physicochemical properties of fermented cassava starch (polvilho azedo ) 显示文摘 | Anida M M Gomes Claudio E Mendes da Silva Nagila M P S Ricardo | 2005 | Carbohydrate Polymers2005，60，1： | 1 |
| 8 | Favorable Chitosan/cellulose Film Combinations for Copper Removal from Aqueous Solutions显示文摘 | LIMA I S LAZARIN A M AIROLDI Claudio | 2005 | International Jour- nal of Biological Macromoleeules2005，36，12： | 1 |
| 9 | Micellar electrokinetic capillary chromatography of 8 - hydroxydeoxyguanosine and other oxidized derivatives of DNA显示文摘 | Carlo G Claudio M Claudio S | 1994 | J Chromatogr B1994，656，： | 1 |
| 10 | Micellar electrokinelic capillary chromatography of 8 - hydroxydeoxyguanosine and other oxidized derivatives of DNA显示文摘 | Carlo G Claudio M Claudio S | 1994 | J Chromatogr B1994，656，： | 1 |
| 11 | VOCs removal from waste gases: gas-phase bioreaetor for the abatement of hexane by Aspergillus niger 显示文摘 | Giorgia S Claudio P Daria F M | 2003 | Chemical Engineering Science2003，58，： | 1 |
| 12 | Chemistry, antioxidant, antibacterial and antifungal activities of volatile oils and their components 显示文摘 | Maria C M Claudio S Gildas N O M | 2009 | Natural Product Communications2009，12，4： | 1 |
| 13 | Increased hypotha-lamic GPR54 signaling:A potential mechanism for initiation of puberty inprimates显示文摘 | MUHAMMAD S CLAUDIO M STEPHANIE B | 2005 | Proc Natl Acad Sci USA2005，102，6： | 1 |
| 14 | Silylating agents grafted onto silica derived from leached chrysotile显示文摘 | Fonseca M G Oilveira A S Claudio A | 2001 | Journal of Colloid and Interface Science2001，240，2： | 1 |
| 15 | Determination of a geomagnetic storm and substorm effects on the ionospheric variability from GPS observations at high latitudes 显示文摘 | LUIS G M JUAN I S MARIA A V Z AMALIA M CLAUDIO B | 2007 | Journal of Atmospheric and Solar-Terrestrial Physics2007，69，8： | 1 |
| 16 | Pax8 activates the enhancer of the human thyroperoxi-dase gene显示文摘 | Claudio E Stetania M Adolfo S | 1998 | Biochem J1998，331，1： | 1 |
| 17 | You can' t manage right what you can' t measure well: technological innovation efficlency显示文摘 | Claudio C C Cristina B S Teresa G M | 2013 | Research Policy2013，，42： | 1 |
| 18 | Transcranial Doppler in a Hispanic-Mestizo population with neurological diseases:a study of sonographic window and its determinants显示文摘 | Alejandro M Claudio S Daniel | 2012 | Brain and Behavior2012，，3： | 1 |
| 19 | Singular spectrum analysis and forecasting of failure time series显示文摘 | M Claudio S Rocco | 2013 | Reliability Engineering and System Safety2013，114，： | 1 |
| 20 | Impact of annealing on the physicochemical properties of unfermented cassava starch 显示文摘 | ANIDA M M G CLAUDIO E M S NAGILA M P S | 2004 | Starch2004，56，9： | 1 |
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