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| 1 | Diagnosis and treatment of hepatocellular carcinoma: An update显示文摘Hepatocellular carcinoma(HCC) is one of the most common malignancies leading to high mortality rates in the general population; in cirrhotic patients, it is the primary cause of death. The diagnosis is usually delayed in spite of at-risk population screening recommendations, i.e., patients infected with hepatitis B or C virus. Hepatocarcinogenesis hinges on a great number of genetic and molecular abnormalities that lead to tumor angiogenesis and foster their dissemination potential. The diagnosis is mainly based on imaging studies such as computed tomography and magnetic resonance, in which lesions present a characteristic classical pattern of early arterial enhancement followed by contrast medium 'washout' in late venous phase. On occasion, when imaging studies are not conclusive, biopsy of the lesion must be performed to establish the diagnosis. The Barcelona Clinic Liver Cancer staging method is the most frequently used worldwide and recommended by the international guidelines of HCC management. Currently available treatments include tumor resection, liver transplant, sorafenib and locoregional therapies(alcoholization, radiofrequency ablation, chemoembolization). The prognosis of hepatocarcinoma is determined according to the lesion's stage and in cirrhotic patients, on residual liver function. Curative treatments, such as liver transplant, are sought in patients diagnosed in early stages; patients in more advanced stages, were not greatly benefitted by chemotherapy in terms of survival until the advent of target molecules such as sorafenib. | Javier Tejeda-Maldonado Ignacio García-Juárez Jonathan Aguirre-Valadez Adrián González-Aguirre Mario Vilatobá-Chapa Alejandra Armengol-Alonso Francisco Escobar-Penagos Aldo Torre Juan Francisco Sánchez-ávila Diego Luis Carrillo-Pérez | 2015 | World Journal of Hepatology2015，7，3： | 22 |
| 2 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 3 | Association between Helicobacter spp.infections and hepatobiliary malignancies:A review显示文摘Hepatobiliary cancers are highly lethal cancers that comprise a spectrum of invasive carcinomas originating in the liver hepatocellular carcinoma,the bile ducts intrahepatic cholangiocarcinoma and extrahepaticcholangiocarcinoma,the gallbladder and the ampulla of Vater(collectively known as biliary tract cancers).These tumors account for approximately 13% of all annual cancer-related deaths worldwide and for 10%-20% of deaths from hepatobiliary malignancies.Cholangiocarcinoma(CCA) is a devastating disease that displays a poor survival rate for which few therapeutic options are available.Population genetics,geographical and environmental factors,cholelithiasis,obesity,parity,and endemic infection with liver flukes have been identified as risk factors that influence the development of biliary tract tumors.Other important factors affecting the carcinogenesis of these tumors include chronic inflammation,obstruction of the bile ducts,and impaired bile flow.It has been suggested that CCA is caused by infection with Helicobacter species,such as Helicobacter bilis and Helicobacter hepaticus,in a manner that is similar to the reported role of Helicobacter pylori in distal gastric cancer.Due to the difficulty in culturing these Helicobacter species,molecular methods,such as polymerase chain reaction and sequencing,or immunologic assays have become the methods of choice for diagnosis.However,clinical studies of benign or malignant biliary tract diseases revealed remarkable variability in the methods and the findings,and the use of uniform and validated techniques is needed. | Fany Karina Segura-López Alfredo Güitrón-Cantú Javier Torres | 2015 | World Journal of Gastroenterology2015，21，5： | 9 |
| 4 | Clinical scenarios for the use of S100β as a marker of hepatic encephalopathy显示文摘AIM: To evaluate the association between serum concentrations of S100β in patients with cirrhosis and the presence of low grade hepatic encephalopathy(HE).METHODS: This was a cross-sectional study. The population was categorized into four groups healthy subjects, cirrhosis without HE, cirrhosis with covert hepatic encephalopathy(CHE) and cirrhosis with overt HE. Kruskal-Wallis, Mann Whitney's U with Bonferroni adjustment Spearman correlations and area under the ROC were used as appropriate.RESULTS: A total of 61 subjects were included, 46 cirrhotic patients and 15 healthy volunteers. S100β values were different among all groups, and differences remained significant between groups 1 and 2(P < 0.001), and also between groups 2 and 3(P = 0.016), but not between groups 3 and 4. In cirrhotic patients with HE S100β was higher than in patients without HE [0.18(0.14-0.28) ng/m L vs 0.11(0.06-0.14) ng/m L, P < 0.001]. There was a close correlation between serum concentrations of S100β and psychometric hepatic encephalopathy score in patients with cirrhosis without HE compared to the patients with cirrhosis with CHE(r =-0.413, P = 0.019). ROC curve analysis yielded > 0.13 ng/m L as the best cutoff value of S100β for the diagnosis of HE(sensitivity 83.3%, specificity 63.6%).CONCLUSION: Serum concentrations of S100β are higher in patients with cirrhosis than in healthy volunteers, and are further increased in the presence of hepatic encephalopathy. The results suggest that serum biomarkers such as S100β could help in the correct characterization of incipient stages of HE. | Andrés Duarte-Rojo Astrid Ruiz-Margáin Ricardo U Macias-Rodriguez Francisco Javier Cubero José Estradas-Trujillo Rosa Ma Munoz-Fuentes Aldo Torre | 2016 | World Journal of Gastroenterology2016，22，17： | 4 |
| 5 | Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis显示文摘AIM Evaluate the association between phase angle and the development of hepatic encephalopathy in the longterm follow-up of cirrhotic patients.METHODS This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. MannWhitney's U and χ2 tests were used as appropriate. Kaplan-Meier curves and Cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic encephalopathy.RESULTS Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy(18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. KaplanMeier curves showed a higher proportion of HE in the group with low phase angle(39%) compared to the normal phase angle group(13%)(P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the Cox regression multivariate analysis [hazard ratio = 1.80(1.07-3.03)]. CONCLUSION In our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis. | Astrid Ruiz-Margáin Ricardo Ulises Macías-Rodríguez Javier Ampuero Francisco Javier Cubero Luis Chi-Cervera Silvia L Ríos-Torres Andrés Duarte-Rojo Ángeles Espinosa-Cuevas Manuel Romero-Gómez Aldo Torre | 2016 | World Journal of Gastroenterology2016，22，45： | 4 |
| 6 | Management of hepatitis B virus infection after liver transplantation显示文摘Chronic hepatitis B virus(HBV) infection is responsible for up to 30% of cases of liver cirrhosis and up to 53% of cases of hepatocellular carcinoma. Liver transplantation(LT) is the best therapeutic option for patients with end-stage liver failure caused by HBV. The success of transplantation, though, depends on receiving prophylactic treatment against post-transplant viral reactivation. In the absence of prophylaxis, liver transplantation due to chronic hepatitis B(CHB) is associated with high rates of viral recurrence and poor survival. The introduction of treatment with hepatitis B immunoglobulins(HBIG) during the 1990 s and later the incorporation of oral antiviral drugs have improved the prognosis of these patients. Thus, LT for CHB is now a universally accepted option, with an estimated 5 years survival of around 85% vs the 45% survival seen prior to the introduction of HBIG. The combination of lamivudine plus HBIG has for many years been the most widely used prophylactic regimen. However, with the appearance of new more potent oral antiviral agents associated with less resistance(e.g., entecavir and tenofovir) for the treatment of CHB, new prophylactic strategies are being designed, either in combination with HBIG or alone as a monotherapy. These advances have allowed for more personalized prophylaxis based on the individual risk profile of a given patient. In addition, the small pool of donors has required the use of anti-HBc-positive donors(with the resulting possibility of transmitting HBV from these organs), which has been made possible by suitable prophylactic regimens. | Miguel Jiménez-Pérez Rocío González-Grande José Mostazo Torres Carolina González Arjona Francisco Javier Rando-Mu?oz | 2015 | World Journal of Gastroenterology2015，21，42： | 3 |
| 7 | Zinc bioleaching from an iron concentrate using Acidithiobacillus ferrooxidans strain from Hercules Mine of Coahuila,Mexico显示文摘The iron concentrate from Hercules Mine of Coahuila,Mexico,which mainly contained pyrite and pyrrhotite,was treated by the bioleaching process using native strain Acidithiobacillus ferrooxidans (A.ferrooxidans) to determine the ability of these bacteria on the leaching of zinc.The native bacteria were isolated from the iron concentrate of the mine.The bioleaching experiments were carried out in shake flasks to analyze the effects of pH values,pulp density,and the ferrous sulfate concentration on the bioleaching process.The results obtained by microbial kinetic analyses for the evaluation of some aspects of zinc leaching show that the native bacteria A.ferrooxidans,which is enriched with a 9K Silverman medium under the optimum conditions of pH 2.0,20 g/L pulp density,and 40 g/L FeSO4,increases the zinc extraction considerably observed by monitoring during15 d,i.e.,the zinc concentration has a decrease of about 95% in the iron concentrate. | Diola Marina Nunez-Ramirez Aquiles Solis-Soto JavierLopez-Miranda Javier Lopez-Miranda Benito Pereyra-Alfere Mirtam Rutlaga-Qumones Luis Medina- Torres Hiram Medrano-Roldan | 2011 | International Journal of Minerals,Metallurgy and Materials2011，18，5： | 3 |
| 8 | Occult hepatitis B virus infection among Mexican human immunodeficiency virus-1-infected patients显示文摘AIM: To determine the frequency of occult hepatitis B infection(OHBI) in a group of human immunodeficiency virus(HIV)-1+/ hepatitis B surface antigen negative(HBsAg)- patients from Mexico. METHODS: We investigated the presence of OHBI in 49 HIV-1+/HBsAg- patients. Hepatitis B virus(HBV) DNA was analyzed using nested PCR to amplify the Core(C) region and by real-time PCR to amplify a region of the S and X genes. The possible associations between the variables and OHBI were investigated using Pearson's χ2 and/or Fisher's exact test.RESULTS: We found that the frequency of OHBI was 49% among the group of 49 HIV-1+/HBsAg- patients studied. The presence of OHBI was significantly associated with the HIV-1 RNA viral load [odds ratio(OR) = 8.75; P = 0.001; 95%CI: 2.26-33.79] and with HIVantiretroviral treatment with drugs that interfere with HBV replication(lamivudine, tenofovir or emtricitabine)(OR = 0.25; P = 0.05; 95%CI: 0.08-1.05). CONCLUSION: The OHBI frequency is high among 49 Mexican HIV-1+/HBsAg- patients and it was more frequent in patients with detectable HIV RNA, and less frequent in patients who are undergoing HIV-ARV treatment with drugs active against HBV. | Ma Teresa Alvarez-Muoz Angelica Maldonado-Rodriguez Othon Rojas-Montes Rocio Torres-Ibarra Fernanda Gutierrez-Escolano Guillermo Vazquez-Rosales Alejandro Gomez Onofre Muoz Javier Torres Rosalia Lira | 2014 | World Journal of Gastroenterology2014，20，37： | 3 |
| 9 | Management of Helicobacter pylori infection in Latin America: A Delphi technique-based consensus显示文摘AIM: To optimize diagnosis and treatment guidelines for this geographic region, a panel of gastroenterologists, epidemiologists, and basic scientists carried out a structured evaluation of available literature.METHODS: Relevant questions were distributed among the experts, who generated draft statements for consideration by the entire panel. A modified three-round Delphi technique method was used to reach consensus. Critical input was also obtained from representatives of the concerned medical community. The quality of the evidence and level of recommendation supporting each statement was graded according to United States Preventive Services Task Force criteria.RESULTS: A group of ten experts was established. The survey included 15 open-ended questions that were distributed among the experts, who assessed the articles associated with each question. The levels of agreement achieved by the panel were 50% in the first round, 73.3% in the second round and 100% in the third round. Main consensus recommendations included:(1) when available, urea breath and stool antigen test(HpSA) should be used for non-invasive diagnosis;(2) detect and eradicate Helicobacter pylori(H. pylori) in all gastroscopy patients to decrease risk of peptic ulcer disease, prevent o retard progression in patients with preneoplastic lesions, and to prevent recurrence in patients treated for gastric cancer;(3) further investigate implementation issues and health outcomes of H. pylorieradication for primary prevention of gastric cancer in high-risk populations;(4) prescribe standard 14-d triple therapy or sequential therapy for first-line treatment;(5) routinely assess eradication success post-treatment in clinical settings; and(6) select second- and third-line therapies according to antibiotic susceptibility testing.CONCLUSION: These achievable steps toward better region-specific management can be expected to improve clinical health outcomes. | Antonio Rollan Juan Pablo Arab M Constanza Camargo Roberto Candia Paul Harris Catterina Ferreccio Charles S Rabkin Juan Cristóbal Gana Pablo Cortés Rolando Herrero Luisa Durán Apolinaria García Claudio Toledo Alberto Espino Nicole Lustig Alberto Sarfatis Catalina Figueroa Javier Torres Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，31： | 2 |
| 10 | Conservative management of perforated duodenal diverticulum: A case report and review of the literature显示文摘Duodenal diverticula are a relatively common condition. They are asymptomatic, unless they become complicated, with perforation being the rarest but most severe complication. Surgical treatment is the most frequently performed approach. We report the case of a patient with a perforated duodenal diverticulum, which was diagnosed early and treated conservatively with antibiotics and percutaneous drainage of secondary retroperitoneal abscesses. We suggest this method could be an acceptable option for the management of similar cases, provided that the patient is in good general condition and without septic signs. | David Martínez-Cecilia Alvaro Arjona Sánchez Manuel Gómez álvarez Eva Torres Tordera Antonio Luque Molina Victor Valentí Azcárate Javier Briceo Delgado Francisco Javier Padillo Pedro López-Cillero Sebastián Rufián Pea | 2008 | World Journal of Gastroenterology2008，14，12： | 2 |
| 11 | 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘 | E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- | 2011 | The Lancet2011，，9790： | 2 |
| 12 | Renal Failure in Patients With Cirrhosis and Sepsis Unrelated to Spontaneous Bacterial Peritonitis: Value of MELD Score显示文摘 | Carlos Terra Mónica Guevara Aldo Torre Rosa Gilabert Javier Fernández Marta Martín-Llahí Maria E. Baccaro Miquel Navasa Conxita Bru Vicente Arroyo Juan Rodés Pere Ginès | 2005 | Gastroenterology2005，，6： | 2 |
| 13 | The ρ-variation of the Hermitian Riesz Transform显示文摘在这份报纸,我们在 Hilbert 变换和与尺寸 1 的 Hermite 操作符联系的 Riesz 变换的摆动和变化的加权的 L p 空格证明行为。我们证明这个操作员印射 L p (? , w (x) dx ) 进自己 w 什么时候是在 A 的重量为 1 的 p 班 < p < 鈭吗?为 p = 1 我们为 A 得到弱类型 1 个班。加权估计也在极端情况 p = 鈭被获得?关键词摆动 -- 蟻 - 变化单个的 integral-Hermite 操作员先生(2000 ) 题目分类 42B20 - Ministerio de Educaci 贸 n y Ciencia (西班牙) 支持的 42C05,资助 MTM 2008-066621-C02-01/02 和会议 de Andaluc 铆 a,资助 FQM-354 和 P06-FQM-01509;第一个作者被 Fundaci 贸 n 卡罗来纳, Ministerio de Cultura y Educaci 贸 n de la 议员煤 b lica 阿根廷和 Universidad Nacional del Comahue | Raquel CRESCIMBENI Francisco Javier MARTíN-REYES Alberto DE LA TORRE José L.TORREA | 2010 | Acta Mathematica Sinica,English Series2010，26，10： | 2 |
| 14 | Toll‐Like Receptors and Cytokines are Upregulated during H elicobacter pylori Infection in Children显示文摘 | Hugo Lagunes‐Servin Javier Torres Carmen Maldonado‐Bernal Martha Pérez‐Rodríguez Sara Huerta‐Yépez Armando Madrazo de la Garza Leopoldo Mu?oz‐Pérez Lourdes Flores‐Luna Guillermo Ramón‐García Margarita Camorlinga‐Ponce | 2013 | Helicobacter2013，，6： | 2 |
| 15 | Impact of chronic liver disease in intensive care unit acquired pneumonia: a prospective study显示文摘 | Marta Pasquale Mariano Esperatti Ernesto Crisafulli Miquel Ferrer Gianluigi Li Bassi Mariano Rinaudo Angels Escorsell Javier Fernandez Antoni Mas Francesco Blasi Antoni Torres | 2013 | Intensive Care Medicine2013，，10： | 2 |
| 16 | Gastric cancer incidence and mortality is associated with altitude in the mountainous regions of Pacific Latin America显示文摘 | Javier Torres Pelayo Correa Catterina Ferreccio Gustavo Hernandez-Suarez Rolando Herrero Maria Cavazza-Porro Ricardo Dominguez Douglas Morgan | 2013 | Cancer Causes & Control2013，，2： | 2 |
| 17 | Effect of additives on the crystallization of cordierite-based glass-ceramics as glazes for floor tiles 显示文摘 | FRANCISCO Jose Torres JAVIER Alarcon | 2003 | J Eur Ceram Soc2003，23，6： | 1 |
| 18 | Effect of methyl ,jasmonate on properties of intact tomato fruit mo- nitored with destructive and nondestructive tests 显示文摘 | Baltazar A Javier E L Torres I R | 2007 | Journal of Food Engineering2007，，80： | 1 |
| 19 | Isothermal crystallisation of iPP/Vectra blends by DSC and simultaneous SAXS and WAXS measurements employing synchrotron radiation显示文摘 | F Javier Torre M Milagros Cortazara M Angeles Gomez | 2003 | Polymer2003，44，： | 1 |
| 20 | Functional Recovery Following Intracoronary Infusion of Autologous Mononuclear Bone Marrow Cells in Patients With Chronic Anterior Myocardial Infarction and Severely Depressed Ventricular Function显示文摘 | José Suárez de Lezo Concepción Herrera Miguel A. Romero Manuel Pan Rosario Jiménez Dolores Carmona José M. Segura Sonia Nogueras Dolores Mesa Javier Suárez de Lezo Djordje Pavlovic Soledad Ojeda Antonio Torres | 2010 | Revista Espa?ola de Cardiología (English Edition)2010，，10： | 1 |
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