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| 1 | Fusobacterium 's link to colorectal neoplasia sequenced: A systematic review and future insights显示文摘AIM To critically evaluate previous scientific evidence on Fusobacterium's role in colorectal neoplasia development.METHODS Two independent investigators systematically reviewed all original scientific articles published between January,2000,and July,2017,using Pub Med,EMBASE,and MEDLINE. A total of 355 articles were screened at the abstract level. Of these,only original scientific human,animal,and in vitro studies investigating Fusobacterium and its relationship with colorectal cancer(CRC) were included in the analysis. Abstracts,review articles,studies investigating other colonic diseases,and studies written in other languages than English were excluded from our analysis. Ninety articles were included after removing duplicates,resolving disagreements between the two reviewers,and applying the above criteria.RESULTS Studies have consistently identified positive associations between Fusobacterium,especially Fusobacterium nucleatum(F. nucleatum),and CRC. Stronger associations were seen in CRCs proximal to the splenic flexure and Cp G island methylator phenotype(CIMP)-high CRCs. There was evidence of temporality and a biological gradient,with increased F. nucleatum DNA detection and quantity along the traditional adenoma-carcinoma sequence and in CIMP-high CRC precursors. Diet may have a differential impact on colonic F. nucleatum enrichment;evidence suggests that high fiber diet may reduce the risk of a subset of CRCs that are F. nucleatum DNA-positive. Data also suggest shorter CRC and disease-specific survival with increased amount of F. nucleatum DNA in CRC tissue. The pathophysiology of enrichment of F. nucleatum and other Fusobacterium species in colonic tissue is unclear;however,the virulence factors and changes to the local colonic environment with disruption of the protective mucus layer may contribute. The presence of a host lectin(Gal-Gal NAc) in the colonic epithelium may also mediate F. nucleatum attachment to CRC and precursors through interaction with an F. nucleatum protein,fibroblast activation protein 2(FAP2). The clinical significance of detection or enrichment of Fusobacterium in colorectal neoplasia is ambiguous,but data suggest a procarcinogenic effect of F. nucleatum,likely due to activation of oncogenic and inflammatory pathways and modulation of the tumor immune environment. This is hypothesized to be mediated by certain F. nucleatum strains carrying invasive properties and virulence factors such as Fad A and FAP.CONCLUSION Evidence suggests a potential active role of Fusobacterium,specifically F. nucleatum,in CRC. Future prospective and experimental human studies would fill an important gap in this literature. | Hisham Hussan Steven K Clinton Kristen Roberts Michael T Bailey | 2017 | World Journal of Gastroenterology2017，23，48： | 9 |
| 2 | Control of coleopteran in sect pests through RNA interference显示文摘 | Baum J A Bogaert T Clinton W | 2007 | Nat Biotechnol2007，25，11： | 1 |
| 3 | Control of coleopteran insect pests through RNA interference显示文摘 | BAUM J A Bogaert T Clinton W at al | 2007 | Nat Biotechnol2007，25，11： | 1 |
| 4 | Physiological responses of perennial bases of Sargassum filipendula from three sites on the west coast of Florida显示文摘 | Clinton J D David A T | 1988 | Bull Mar Sci1988，42，2： | 1 |
| 5 | Comparison of a warm gutta-percha obturation technique and lateral condensation 显示文摘 | CLINTON K VAN HIMEL T | 2001 | J Endod2001，27，11： | 1 |
| 6 | Leveraging spon- sorships on the internet: activation, congruence, and articulation 显示文摘 | CLINTON S WEEKS CORNWELL T | 2008 | Psychol Market2008，25，7： | 1 |
| 7 | Control of coleopteran insect pests through RNA interference 显示文摘 | Baum JA Bogaert T Clinton W | 2007 | Nature Biotechnol- ogy2007，25，11： | 1 |
| 8 | Comparison of a warm gutra-percha obtura- tion technique and lateral condensation 显示文摘 | Clinton K van Himel T | 2001 | J Endod2001，27，11： | 1 |
| 9 | Long +erm nitrogen additions increased surface soil carbon concentration in aforest plantation despite elevated decomposition显示文摘 | Huang Z Q Clinton P W Baisden W T | 2011 | C Biology and Biochemistry2011，43，： | 1 |
| 10 | Physiological responses of perennial bases of Sargassum filipendula from three sites on the west coast of Florida显示文摘 | Clinton J D David A T | 1988 | Bull Mar Sci1988，42，2： | 1 |
| 11 | Associated factors of post-stroke depression among Hong Kong Chinese: a longitudinal study显示文摘 | Sit J W Wong T K Clinton M | 2007 | Psychol Health Med2007，12，2： | 1 |
| 12 | Anxiety and depression among haematological cancer patients attending treatment centres: prevalence and predictors显示文摘 | Clinton - McHarg T Carey M Sanson - Fisher R | 2014 | J Affect Disord2014，165，20： | 1 |
| 13 | Neurogenic radial glial cells in reptile,rodent and human:from mitosis to migration显示文摘 | Weissman T Noctor SC Clinton BK | 2003 | Cereb Cortex2003，13，6： | 1 |
| 14 | Associated factors of post-stroke depression among Hong Kong Chinese:A longitudinal study显示文摘 | Sit J W Wong T K Clinton M | 2007 | Psychol Health Med J2007，12，2： | 1 |
| 15 | Comparison of a warm gutta -perche obturation technique and lateral condensation 显示文摘 | Clinton K Van Himal T | 2001 | J Endod2001，27，1： | 1 |
| 16 | Chronic Wound Biofilms :Pathogenesis and Potential Therapies显示文摘 | CLINTON A CARTER T | 2015 | Lab Med2015，46，4： | 1 |
| 17 | Long- term nitrogen additions increased surface soil carbon concentration in a forest plantation despite e]evated decomposition 显示文摘 | Huang Z Clinton P W Baisden W T | 2011 | Soil Biology and Biochemistry2011，43，2： | 1 |
| 18 | Control of coleopteran insect pests through RNA interference 显示文摘 | BAUM J A BOGAERT T CLINTON W | 2007 | Nature Biotechnol2007，25，11： | 1 |
| 19 | Stroke care in the home: the impact of social support on the general health of family caregivers显示文摘 | SIT J W WONG T K CLINTON M | 2004 | J Clin Nurs2004，13，7： | 1 |
| 20 | Neurogenic radial glial cells in reptile, rodent and human: from mitosis to migration显示文摘 | Weissman T Noctor SC Clinton BK | 2003 | Cereb Cortex2003，13，6： | 1 |
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