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| 1 | 黄芩苷对牙龈成纤维细胞和牙周膜细胞pro-MMP-1和MMP-3表达的影响显示文摘目的 检测黄芩苷对白细胞介素 1β(IL 1β)诱导作用下人牙龈成纤维细胞 (HGF)分泌基质金属蛋白酶 1酶原 (pro MMP 1)的量和牙周膜细胞 (PDLCs)基质金属蛋白酶 3(MMP 3)表达的变化。方法 体外培养HGF和PDLCs,分别运用ELISA和免疫组化方法检测 pro MMP 1的量和MMP 3的表达。结果 与对照组的 (1 96 0± 0 176 ) μg/L相比 ,1μg/L的IL 1β能够显著促进HGF分泌 pro MMP 1(3 333± 0 12 3) μg/L ,且增加PDLCsMMP 3的表达 (P <0 0 0 1) ;加入黄芩苷后能降低HGF的pro MMP 1分泌量 ,其作用呈浓度 (10~ 10 0 0 μg/L)依赖性 ;黄芩苷对IL 1β诱导下PDLCs合成MMP 3的能力没有影响 ,但是能够抑制MMP 3的释放。结论 黄芩苷能够抑制由IL 1β介导的HGF分泌pro MMP 1和PDLCMMP 3的表达 ,提示黄芩苷可用于牙周病的防治。 | 李成章 曹正国 杨茹 尚姝环 金力坚 Cobert EF | 2004 | 中华口腔医学杂志2004，39，3： | 18 |
| 2 | 591 Retrograde cor-onary sinus perfusion : an alternate approach for machineperfusion preservation of donor hearts for transplantation显示文摘 | Cobert ML West LM Jessen ME | 2011 | J Heart Lung Transplant2011，30，4： | 1 |
| 3 | Metabolic characteristics of human hearts preserved for 12 hours by static storage, antegrade perfusion, or retrograde coronary sinus perfusion 显示文摘 | Cobert ML Merritt ME West LM | 2014 | J ThoracCardiovase Surg2014，148，5： | 1 |
| 4 | Monotherapy with methotrexate for primary central nervous lymphoma has single agent activity in the absence of radiotherapy:a single institution cohort显示文摘 | Cobert J Hochberg E Woldenberg N | | 0，，03： | 1 |
| 5 | Characterizing cardiac donation after circulatory death: implications for perfusion preservation显示文摘 | Brant SM Cobert ML West LM | 2014 | Ann Thorac Surg2014，98，6： | 1 |
| 6 | Importance of organ preservation solution composition in reducing myocardial edema during machine perfusion for heart transplantation 显示文摘 | COBERT M PELTZ M WEST L et at | 2010 | Transplant Proc2010，42，5： | 1 |
| 7 | Life-cycle environmental impact of Michelin tweeltire for passenger vehicles显示文摘 | Bras B Cobert A | 2011 | SAE International Journal of Passenger Cars-Mechanical Systems2011，4，1： | 1 |
| 8 | Importance of organ preservation solution composition in reducing myocardial edema during machine perfusion for heart transplantation 显示文摘 | COBERT M L PELTZ M WEST L M | 2010 | Transplant Proc2010，42，5： | 1 |
| 9 | Nervous System Invasion occurs in 4% percent of chronic lymphocytic leukemia显示文摘 | Cobert J Hochberg E P Abramson J S | 2008 | Blood2008，，42： | 1 |
| 10 | Effects of antegrade and retrograde machine perfusion preservation on cardiac function after transplantation in canines 显示文摘 | BRANT S M ROSENBAUM D H COBERT M L | 2014 | Transplant Proc2014，46，5： | 1 |
| 11 | Examing executive functioning in children with autism spectrum disorder, attention deficit hyperactivity disorder and typical development 显示文摘 | Cobert B A Constantine L J Hendren R | 2009 | Psychi atry Research2009，166，： | 1 |
| 12 | Experimental identification of Ca isotopic fractionations in higher plants显示文摘 | Cobert F Schmitt A D Bourgeade P | 2011 | Geochimica et Cosmochimica Acta2011，75，： | 1 |
| 13 | Myocardial perfusion characteristics during machine perfusion for heart transplantation显示文摘 | Peltz M Cobert ML Rosenbaum DH | | 0，，： | 1 |
| 14 | Myocardial perfusion characteristics during machine perfusion for heart transplanta-tion显示文摘 | Peltz M Cobert M L Rosenbaum D H | | 0，，02： | 1 |
| 15 | Myocardial perfu- sion characteristics during machine perfusion for heart trans- plantation 显示文摘 | Peltz M Cobert ML Rosenbaum DH | 2008 | Surgery2008，144，2： | 1 |
| 16 | “药品安全登记”——它确实有用吗?显示文摘药物不良事件(adverse drug events,ADE)为合格药品的固有属性之一。认识药物的安全性问题,评价影响ADE的因素,并据此制定相应防范措施,可使用药风险减少到最低限度。笔者参考一些最新资料,介绍药品安全登记(drug safety reg-istries)这一概念及其相关法规。 | 谢海棠 Barton Cobert 孙瑞元 | 2009 | 中国临床药理学与治疗学2009，14，1： | 0 |
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