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| 1 | Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia显示文摘Functional gastrointestinal disorders(FGID) are common clinical syndromes diagnosed in the absence of biochemical,structural,or metabolic abnormalities. They account for significant morbidity and health care expenditures and are identifiable across variable age,geography,and culture. Etiology of abdominal pain associated FGIDs,including functional dyspepsia(FD),remains incompletely understood,but growing evidence implicates the importance of visceral hypersensitivity and electromechanical dysfunction. This manuscript explores data supporting the role of visceral hypersensitivity and electromechanical dysfunction in FD,with focus on pediatric data when available,and provides a summary of potential therapeutic targets. | John M Rosen Jose T Cocjin Jennifer V Schurman Jennifer M Colombo Craig A Friesen | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 16 |
| 2 | Aggressive juvenile polyposis in children with chromosome 10q23 deletion显示文摘Juvenile polyps are relatively common findings in children,while juvenile polyposis syndrome(JPS) is a rare hereditary syndrome entailing an increased risk of colorectal cancer.Mutations in BMPR1A or SMAD4 are found in roughly half of patients diagnosed with JPS.Mutations in PTEN gene are also found in patients with juvenile polyps and in Bannayan-Riley-Ruvalcaba syndrome and Cowden syndrome.Several previous reports have described microdeletions in chromosome 10q23 encompassing both PTEN and BMPR1A causing aggressive polyposis and malignancy in childhood.These reports have also described extra-intestinal findings in most cases including cardiac anomalies,developmental delay and macrocephaly.In this report we describe a boy with a 5.75 Mb deletion of chromosome 10q23 and a 1.03 Mb deletion within chromosome band 1p31.3who displayed aggressive juvenile polyposis and multiple extra-intestinal anomalies including macrocephaly,developmental delay,short stature,hypothyroidism,atrial septal defect,ventricular septal defect and hypospadias.He required colectomy at six years of age,and early colectomy was a common outcome in other children with similar deletions.Due to the aggressive polyposis and reports of dysplasia and even malignancy at a young age,we propose aggressive gastrointestinal surveillance in children with 10q23 microdeletions encompassing the BMPR1A and PTEN genes to include both the upper and lower gastrointestinal tracts,and also include a flowchart for an effective genetic testing strategy in children with juvenile polyposis. | Seth Septer Lei Zhang Caitlin E Lawson Jose Cocjin Thomas Attard Holly H Ardinger | 2013 | World Journal of Gastroenterology2013，19，14： | 4 |
| 3 | Rumination syndrome in adolescents显示文摘 | Khan S Hyman PE Cocjin J | 2000 | J Pediatr2000，136，4： | 1 |
| 4 | Comorbidities associatedwith constipation in children referred for colon manometry may maskfimctional diagnoses 显示文摘 | Gertken JT Cocjin J Pehlivanov N | 2005 | J Pediatr Gastroenterol Nutr2005，41，3： | 1 |
| 5 | Bile ductule formation in fetal, neonatal, and infant livers compared with extrahepat- ic biliary atresia 显示文摘 | Cocjin J Rosenthal P Buslon V | 1996 | Hepatology1996，24，3： | 1 |
| 6 | Bile ductule formation in fetal, neonatal, and infant livers compared with extrahepatic biliary atresia显示文摘 | J Cocjin P Rosenthal V Buslon L Luk L Barajas SA Geller B Ruebner S French | 1996 | Hepatology1996，，3： | 1 |
| 7 | Multicenter, Randomized, Placebo-Controlled Trial of Amitriptyline in Children With Functional Gastrointestinal Disorders显示文摘 | Miguel Saps Nader Youssef Adrian Miranda Samuel Nurko Paul Hyman Jose Cocjin Carlo Di Lorenzo | 2009 | Gastroenterology2009，，4： | 1 |
| 8 | Bile ductile formation in feral,neonatal,and infant livers compared with extrahepatic biliary atresia显示文摘 | Rosenthal P Ruslon V | 1996 | Hepatology1996，24，3： | 1 |
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