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| 1 | Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma显示文摘Chronic infection with viral hepatitis affects half a billion individuals worldwide and can lead to cirrhosis,cancer,and liver failure.Liver cancer is the third leading cause of cancer-associated mortality,of which hepatocellular carcinoma(HCC)represents 90%of all primary liver cancers.Solid tumors like HCC are complex and have heterogeneous tumor genomic profiles contributing to complexity in diagnosis and management.Chronic infection with hepatitis B virus(HBV),hepatitis delta virus(HDV),and hepatitis C virus(HCV)are the greatest etiological risk factors for HCC.Due to the significant role of chronic viral infection in HCC development,it is important to investigate direct(viral associated)and indirect(immune-associated)mechanisms involved in the pathogenesis of HCC.Common mechanisms used by HBV,HCV,and HDV that drive hepatocarcinogenesis include persistent liver inflammation with an impaired antiviral immune response,immune and viral protein-mediated oxidative stress,and deregulation of cellular signaling pathways by viral proteins.DNA integration to promote genome instability is a feature of HBV infection,and metabolic reprogramming leading to steatosis is driven by HCV infection.The current review aims to provide a brief overview of HBV,HCV and HDV molecular biology,and highlight specific viral-associated oncogenic mechanisms and common molecular pathways deregulated in HCC,and current as well as emerging treatments for HCC. | Simmone D'souza Keith CK Lau Carla S Coffin Trushar R Patel | 2020 | World Journal of Gastroenterology2020，26，38： | 25 |
| 2 | Clinical relevance of hepatitis B virus variants显示文摘The hepatitis B virus(HBV) is a global public health problem with more than 240 million people chronically infected worldwide, who are at risk for end-stage liver disease and hepatocellular carcinoma. There are an estimated 600000 deaths annually from complications of HBV-related liver disease. Antiviral therapy with nucleos/tide analogs(NA) targeting the HBV polymerase(P) can inhibit disease progression by long-term suppression of HBV replication. However, treatment may fail with first generation NA therapy due to the emergence of drugresistant mutants, as well as incomplete medication adherence. The HBV replicates via an error-prone reverse transcriptase leading to quasispecies. Due to overlapping open reading frames mutations within the HBV P can cause concomitant changes in the HBV surface gene(S) and vice versa. HBV quasispecies diversity is associated with response to antiviral therapy, disease severity and long-term clinical outcomes. Specific mutants have been associated with antiviral drug resistance, immune escape, liver fibrosis development and tumorgenesis. An understanding of HBV variants and their clinical relevance may be important for monitoring chronic hepatitis B disease progression and treatment response. In this review, we will discuss HBV molecular virology, mechanism of variant development, and their potential clinical impact. | Shan Gao Zhong-Ping Duan Carla S Coffin | 2015 | World Journal of Hepatology2015，7，8： | 5 |
| 3 | Functional role of matrix metalloproteinases in ovarian tumor cell plasticity显示文摘 | Sood AK Fletcher MS Coffin JE | 2004 | American Journal of Obstetrics and Gynecology2004，，04： | 2 |
| 4 | Algorithms for evaluating the appropriateness of blood transfusion 显示文摘 | COFFIN C MATZ K RICH E | 1989 | Transfusion1989，29，： | 1 |
| 5 | Stable carbon and nitrogen isotope analysis of TNT: Two- dimensional source identification显示文摘 | Coffin R B Miyares P H Kelley C A | 2001 | Environ Toxicol Chem2001，20，12： | 1 |
| 6 | Long-term follow-up after interbody fusion of the cervical spine显示文摘 | Coffin J Ceusona E Vantomme N | 2004 | J Spinal Disord tech2004，17，2： | 1 |
| 7 | Origin and evolution of a submarine large igneous province: The Kerguelen plateau and Broken ridge, southem Indian ocean显示文摘 | Frey F A Coffin M F Wallace P J | 2000 | Earth and Planetary Science Letters2000，176，： | 1 |
| 8 | Physical and mechanical proper-ties of highly plasticized pectin/starch films显示文摘 | Coffin D R Fishman M L | 1994 | J Appl Polym Sci1994，54，9： | 1 |
| 9 | The voices of history: theorizing the interpersonal semantics of historical discourses in Text显示文摘 | Coffin C | 2002 | (4)2002，，4： | 1 |
| 10 | Preliminary clinical experience with the Bryan Cervical Disc Prosthesis 显示文摘 | Coffin J Casey A Kehr P | 2002 | Neurosurgery2002，51，3： | 1 |
| 11 | Bus stop design and automated guidance for low-floor buses显示文摘 | Dejeamrnes M Coffin F Ladreyt T | 1999 | Transportation Research Record1999，1666，： | 1 |
| 12 | Genomic instability is associated with lack of telomerase activation in ovarian cancer 显示文摘 | Landen C N Klingelhutz A Coffin J E | 2004 | Cancer Biol Ther2004，3，12： | 1 |
| 13 | Medical therapy and physical maneuvers in the treatment of the vasovagal syncope and orthostatic hypotension显示文摘 | Raj SR Coffin ST | 2013 | Prog Cardiovasc Dis2013，55，4： | 1 |
| 14 | Polyadenylation at correct sites in genome RNA is not required for retrovirus replication or genome eneapsi- dation显示文摘 | Swain A Coffin JM | 1989 | J Virol1989，63，8： | 1 |
| 15 | Production Effciency and Agricultural Technologies in the Ethiopian Agriculture显示文摘 | Mariam Y Coffin G | | McGill University0，，： | 1 |
| 16 | ICD-9 codes for identifyinginfluenza hospitalizations in children显示文摘 | Keren R Wheeler A Coffin SE | 2006 | Emerg Infect Dis2006，12，10： | 1 |
| 17 | Extrapulmonary in flammatory pseudotumor: a clinico-pathologic and immunohis-tochemical study of 84 case显示文摘 | Coffin CM Watterson J Priest JR | 1995 | Am J Surg Pathol1995，19，： | 1 |
| 18 | Effect of the keppa agonist fedotozine on perception of gastic distension in healthy 显示文摘 | Coffine B Bouhassira D Chollt R | 1996 | Aliment Pharmacol ther1996，10，： | 1 |
| 19 | Molecular characterization of intrahepatic and extrahepatic hepatitis B virus (HBV) reservoirs in patients on suppressive antiviral therapy显示文摘 | Coffin CS Mulrooney-Cousins PM Peters MG | 2011 | J Viral Hepat2011，18，6： | 1 |
| 20 | Low cycle fatigue显示文摘 | COFFIN I F Jr | 1963 | Materials Engineering Quarterly1963，3，1： | 1 |
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