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| 1 | Computed tomography-guided percutaneous core needle biopsy in pancreatic tumor diagnosis显示文摘AIM: To evaluate the techniques, results, and complications related to computed tomography(CT)-guided percutaneous core needle biopsies of solid pancreatic lesions.METHODS: CT-guided percutaneous biopsies of solid pancreatic lesions performed at a cancer reference center between January 2012 and September 2013 were retrospectively analyzed. Biopsy material was collected with a 16-20 G Tru-Core needle(10-15 cm; Angiotech, Vancouver, CA) using a coaxial system and automatic biopsy gun. When direct access to the lesion was not possible, indirect(transgastric or transhepatic) access or hydrodissection and/or pneumodissection maneuvers were used. Characteristics of the patients, lesions, procedures, and histologic results were recorded using a standardized form. RESULTS: A total of 103 procedures included in the study were performed on patients with a mean age of 64.8 year(range: 39-94 year). The mean size of the pancreatic lesions was 45.5 mm(range: 15-195 mm). Most(75/103, 72.8%) procedures were performed via direct access, though hydrodissection and/or pneumodissection were used in 22.2%(23/103) of cases and indirect transhepatic or transgastric access was used in 4.8%(5/103) of cases. Histologic analysis was performed on all biopsies, and diagnoses were conclusive in 98.1%(101/103) of cases, confirming3.9%(4/103) of tumors were benign and 94.2%(97/103) were malignant; results were atypical in 1.9%(2/103) of cases, requiring a repeat biopsy to diagnose a neuroendocrine tumor, and surgical resection to confirm a primary adenocarcinoma. Only mild/moderate complications were observed in 9/103 patients(8.7%),and they were more commonly associated with biopsies of lesions located in the head/uncinate process(n =8), than of those located in the body/tail(n = 1) of the pancreas, but this difference was not significant.CONCLUSION: CT-guided biopsy of a pancreatic lesion is a safe procedure with a high success rate, and is an excellent option for minimally invasive diagnosis. | Chiang J Tyng Maria Fernanda A Almeida Paula NV Barbosa Almir GV Bitencourt José Augusto AG Berg Macello S Maciel Felipe JF Coimbra Luiz Henrique O Schiavon Maria Dirlei Begnami Marcos D Guimares Charles E Zurstrassen Rubens Chojniak | 2015 | World Journal of Gastroenterology2015，21，12： | 14 |
| 2 | Effects of phosphodiesterase inhibition on the inflammatory response following shock:role of pentoxifylline显示文摘 | Coimbra R Melbostad H Hoyt D B | 2004 | J Trauma2004，56，2： | 1 |
| 3 | Resveratrol attenuates cisplatin-induced nephrotoxicity in rats显示文摘 | do AMARAL C L FRANCESCATO H D C COIMBRA T M | 2008 | Archives of Toxicology2008，82，6： | 1 |
| 4 | Protective effect of quercetin on the evolution of cisplatin-induced acute tubular necrosis显示文摘 | FRANCESCATO H D C COIMBRA T M COSTA R S | 2004 | Kidney and Blood Pressure Research2004，27，3： | 1 |
| 5 | Hypertonic saline resuscitation decreases susceptibility to sepsis after hemorrhagic shock 显示文摘 | Coimbra R Hoyt D B Junger W G | 1997 | J Trauma1997，42，4： | 1 |
| 6 | The Pontine A5 Noradrenergic Cells Which Project to the Spinal Cord Dorsal Horn are Reciprocally Connected with the Caudal Ventrolateral Medulla in the Rat 显示文摘 | TAVARES I LIMA D COIMBRA A | 1997 | Neurosci1997，9，11： | 1 |
| 7 | Effect of pH and salt concentration on the solubility and density of egg yolk and plasma egg yolk 显示文摘 | SOUSA R D S COIMBRA J S R ROJAS E E G | 2007 | LWT2007，40，： | 1 |
| 8 | Local affine multidimensional projection 显示文摘 | Joia P Coimbra D Cuminato J A | 2011 | IEEE Transactions on Visualization and Computer Graphics2011，17，12： | 1 |
| 9 | Use of FT-IR spectroscopy to folow the effect of processing in cell wall polysac- charide extracts if a sun-dried pear 显示文摘 | FERREIRA D BARROS M A COIMBRA M A | 2001 | Carbohydrate polymer2001，45，2： | 1 |
| 10 | Pentoxifylline reduces acute lung injury in chronic endotoxemia 显示文摘 | Michetti C Coimbra R Hoyt D B | 2003 | J Surg Res2003，115，1： | 1 |
| 11 | Does anti‐hepatitis B virus vaccine make any difference in long‐term number of liver transplantation?显示文摘 | E. Chaib B. G. M. M. Coimbra F. H. F. Galv?o E. R. Tatebe M. S. Shinzato L. A. C D’Albuquerque E. Massad | 2012 | Clin Transplant2012，，6： | 1 |
| 12 | Use of FT-IR spectroscopy to follow the effect of processing in cell wall polysaccharide extracts of a sun-dried pear显示文摘 | Ferreira D Barros A Coimbra M | | 0，，02： | 1 |
| 13 | Hypoxia inducible factor-1 alpha expression in human normal and osteoarthritic chondrocytes 显示文摘 | Coimbra I B Jimenez S A Hawkins D F | 2004 | Osteoarthritis Cartilage2004，12，4： | 1 |
| 14 | Developmental toxicity of endocrine disruptors in early life stages of zebrafish, a genetic and embryogenesis study显示文摘 | SANTOS D MATOS M COIMBRA A M | 2014 | Neurotoxicology and Teratology2014，46，： | 1 |
| 15 | A comparison of confi- dence interval methods for the concordance correlation coeffi- cient and intraclass correlation coefficient with small number of raters显示文摘 | Feng D Svetnik V Coimbra A | 2014 | J Biopharm Stat2014，24，2： | 1 |
| 16 | Epidermal growth factor enhances renal tubule cell regeneration and repair and acceleratesthe recovery of renal failure显示文摘 | Humes H Cielkinski D Coimbra T | 1989 | J Clin Invest1989，84，： | 1 |
| 17 | Sensory interaction on static balance= a comparison concerning the history of falls of community-dwelling elderly显示文摘 | Ricci NA de Faria Figueiredo Goncalves D Coimbra AM | 2009 | Geriatr Gerontol Int2009，9，2： | 1 |
| 18 | Pentoxifylline reduces acute lung injury in chronic endotoxemia 显示文摘 | Michetti C Coimbra R Hoyt D B | 2003 | J Surg Res2003，115，1： | 1 |
| 19 | Studies of the cell surface properties of Candida species and relation to the production of biosurfactants for environmental applica- tions 显示文摘 | COIMBRA C D RUFINO R D LUNA J M | 2009 | Current Microbiology2009，58，3： | 1 |
| 20 | Zinc Oxide Nanoparticles: Synthesis, Antimicrobial Activity and Food Packaging Applications显示文摘 | ESPITIA P J P SOARES N D F F COIMBRA J S D R | 2012 | Food and Bioprocess Technology2012，5，5： | 1 |
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