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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | Fungal keratitis: changing patho- gens and risk {actors显示文摘 | Jurkunas U Behlau I Colby K | 2009 | Cornea2009，28，6： | 1 |
| 3 | Management of traumatic cataracts (Article)显示文摘 | Mian SI Azar DT Colby K | 2002 | Int Ophthalmol Clin2002，42，3： | 1 |
| 4 | Transaction cost measurement for evaluating environmental policies 显示文摘 | McCann L Colby B Easter K W | 2005 | Ecological Economics2005，52，： | 1 |
| 5 | Fungal keratitis: changing pathogens and risk factors显示文摘 | Jurkunas U Behlau I Colby K | 2009 | Cornea2009，28，6： | 1 |
| 6 | Management of open globe injuries显示文摘 | Colby K | 1999 | Int Ophthalmol Clin1999，39，1： | 1 |
| 7 | Overexpression of cyclooxygenase-2 (COX-2) in the mouse urinary bladder induces the expression of immuneand cell proliferation-related genes 显示文摘 | Wang X Colby J K Rengel R C | 2009 | Mol Carcinog2009，48，1： | 1 |
| 8 | Fungal keratitis:changing pathogens and risk factors显示文摘 | Jurkunas U Behlau I Colby K | 2009 | Cornea2009，28，： | 1 |
| 9 | Transaction Costs Measurement for Evaluating Environmental Policies显示文摘 | McCann L Colby B Easter K W | 2005 | Ecological Economics2005，52，4： | 1 |
| 10 | What length scales control the dynamics of miscible polymer blends显示文摘 | Kant R Kumar S K Colby R H | 2003 | Macromolecules2003，36，10： | 1 |
| 11 | 查看详情显示文摘 | Miniscalco W Lane S Fisher K Waite S Howlett M Colby K Smith I | | 0，，： | 1 |
| 12 | Tilting,cotilting,and serially tilted rings显示文摘 | Colby R R Fuller K R | 1997 | Communications in Algebra1997，22，10： | 1 |
| 13 | Histopathologic variability in usual and nonspecific interstitial pneumonias显示文摘 | Flaherty K R Travis W D Colby T V | 2001 | Am J Respir Crit Care Med2001，164，9： | 1 |
| 14 | Incorporating uncertainty in the PROMETHEE MCDA method 显示文摘 | Hyde K M Maier H R Colby C B | 2003 | Journal of Multi-Criteria Decisions Analysis2003，，12： | 1 |
| 15 | Genetics of anterior and stromal corneal dystrophies显示文摘 | Poulaki V Colby K | 2008 | Semin Ophthalmol2008，23，1： | 1 |
| 16 | Slurry pump glandseal wear显示文摘 | RIDGWAY N COLBY C B O’NEILL B K | 2009 | Tribology International2009，42，： | 1 |
| 17 | Treatment of Leber's hereditary optic neurop-athy:theory to practice显示文摘 | Johns D R Colby K A | 2002 | Semin Ophthalmol2002，17，1： | 1 |
| 18 | Long-term follow-up of lower lumbar fusion patients 显示文摘 | LEHMANN T R SPRATT K F TOZZI J E WEINSTEIN JN REINARZ S J EL-KHOURY GY COLBY H | 1987 | Spine1987，12，97： | 1 |
| 19 | Estimating the cost of desalination plants using a cost database 显示文摘 | Wittholz M K O'Neill B K Colby C B etal | 2008 | Desalination2008，229，229： | 1 |
| 20 | Management of traumatic cataracts (Article)显示文摘 | Mian S I Azar D T Colby K | 2002 | International Ophthalmology Clinics2002，42，1： | 1 |
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