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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Novel bronsted acidic ionic liquids and their use as dual solvent-catalysts显示文摘 | Cole A C Jensen J L Ntai I | 2002 | Journal of the American Chemical Society2002，124，21： | 1 |
| 3 | 查看详情显示文摘 | Cole A C Jensen J L Ntai I Tran K L T Weaver K J Forbes D C Davis J H Jr | | 0，，： | 1 |
| 4 | Novel Bronsted acidic ionic liquids and their use as dual solvent-catalysts显示文摘 | COLE A C JENSEN J L NTAI I | 2002 | Journal of the American Chemical Society2002，124，21： | 1 |
| 5 | J Am Chem Soc显示文摘 | Cole A C Jensen J L Ntai I | 2002 | 124:5962-59632002，124，： | 1 |
| 6 | Field performance of two peanut cultivars relative to aflatoxin contamination显示文摘 | Davidson J I Hill R A Cole R J | 1983 | Peanut Science1983，10，1： | 1 |
| 7 | Novel brφnsted acidic ionic liquids and their use as dual solvent-catalysts 显示文摘 | Cole A C Jensen J L Ntai I | 2002 | J Am Chem Soc2002，124，： | 1 |
| 8 | Novel Brφnsted Acidic Ionic Liquids and Their use as Dual Solvent-catalysts显示文摘 | Cole A C Jensen J L Ntai I | 2002 | J Am Chem Soc2002，124，59： | 1 |
| 9 | The initial mechanism of corrosion of zinc by sodium chloride particle deposition显示文摘 | NEUFELD A K COLE I S BOND A M FURMAN S A | 2002 | Corrosion Science2002，44，： | 1 |
| 10 | Novel Br6nsted Acidic Ionic Liquids and Their Use as Dual Solvent-Catalysts显示文摘 | Cole A C Jensen J L Ntai I | 2002 | J Am Chem Soc2002，124，21： | 1 |
| 11 | Using fourier transforming infrared analysis to detect corrosion products on the surface of metals exposed to atmospheric conditions显示文摘 | NEUFELD A K COLE I S | 1997 | Corrosion1997，53，10： | 1 |
| 12 | Core transcriptional regulatory circuitry in human embryonic stem cells 显示文摘 | Boyer L A Lee T I Cole M F | 2005 | Cell2005，122，6： | 1 |
| 13 | A Data-constrained Computational Model for Morphology Structures显示文摘 | Yang Y S Tulloh A Cole I | | 0，，： | 1 |
| 14 | A data-constrained Computational Model for Morphology Structures显示文摘 | YANG Sam Tulloh A Cole I | 2007 | Journal of the Australasian Ceramic Society2007，42，2： | 1 |
| 15 | Facies architecture of Kookfontein shelf edge delta,Tanqua-Karoo Basin(South Africa):Implications for facies analysis and modeling显示文摘 | Sonibare W A Mikes D Cole D I | 2011 | South Africa Journal of Geology2011，114，： | 1 |
| 16 | Novel Bronsted acidic ionic liquids and their use as dual solvent-catalysts显示文摘 | Cole A C Jensen J L Ntai I | 2002 | Journal of the American Chemical Society2002，124，21： | 1 |
| 17 | Novel Bronsted acidic ionic liquids and their use as dual solvent-catalysts显示文摘 | Cole A C Jensen J L Ntai I | 2002 | J Am Chem Soc2002，124，21： | 1 |
| 18 | Comparisons of Scutellaria baicalensis, Scutellaria lateriflora and Scutellaria racemosa: genome size, antioxidant potential and phytochemistry显示文摘 | COLE I B CAO Jin ALAN A R | 2008 | Planta Medica2008，74，4： | 1 |
| 19 | Novel Bronsted acidic ionic liquids and their use as dual solvent-catalysts 显示文摘 | Cole A C Jensen J L Ntai I | 2002 | J Am Chem Soc2002，124，： | 1 |
| 20 | Novel Brφnsted Acidic Ionic Liquids and Their Use as Dual Solvent - Catalysts 显示文摘 | Cole A C Jensen J L Ntai I | 2002 | J AM Chem Soc2002，124，： | 1 |
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